Folic Acid Supplementation and Risk for Imperforate Anus in China
Maternal consumption of folic acid before pregnancy and during early pregnancy is associated with a reduced risk for some birth defects. Whether folic acid can reduce the risk for imperforate anus is unknown. As part of a public health campaign conducted in China from 1993 through 1995, the outcomes...
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| Veröffentlicht in: | American journal of epidemiology 2001-12, Vol.154 (11), p.1051-1056 |
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| creator | Myers, Melanie F. Li, Song Correa-Villaseñor, Adolfo Li, Zhu Moore, Cynthia A. Hong, Shi Xin Berry, Robert J. |
| description | Maternal consumption of folic acid before pregnancy and during early pregnancy is associated with a reduced risk for some birth defects. Whether folic acid can reduce the risk for imperforate anus is unknown. As part of a public health campaign conducted in China from 1993 through 1995, the outcomes of pregnancies of ≥20 weeks' gestation were evaluated among women using folic acid supplements. The women were asked to take one pill containing 400 μg of folic acid (without other vitamins) every day from the time of their premarital examination until the end of their first trimester of pregnancy. Rates of imperforate anus and risk ratios for imperforate anus among the offspring of these women were calculated according to folic acid use. Among the offspring of women who took folic acid and women who did not take folic acid, 20 and 30 infants with imperforate anus were identified, respectively. The rate of imperforate anus was 3.1 per 10,000 among the offspring of women who did not take folic acid and 1.6 per 10,000 among the offspring of women who took folic acid; adjusted for maternal age, the risk ratio was 0.59 (95% confidence interval: 0.33, 1.07). Daily maternal consumption of 400 μg of folic acid before and during early pregnancy may reduce the risk for imperforate anus. |
| doi_str_mv | 10.1093/aje/154.11.1051 |
| format | Article |
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Whether folic acid can reduce the risk for imperforate anus is unknown. As part of a public health campaign conducted in China from 1993 through 1995, the outcomes of pregnancies of ≥20 weeks' gestation were evaluated among women using folic acid supplements. The women were asked to take one pill containing 400 μg of folic acid (without other vitamins) every day from the time of their premarital examination until the end of their first trimester of pregnancy. Rates of imperforate anus and risk ratios for imperforate anus among the offspring of these women were calculated according to folic acid use. Among the offspring of women who took folic acid and women who did not take folic acid, 20 and 30 infants with imperforate anus were identified, respectively. The rate of imperforate anus was 3.1 per 10,000 among the offspring of women who did not take folic acid and 1.6 per 10,000 among the offspring of women who took folic acid; adjusted for maternal age, the risk ratio was 0.59 (95% confidence interval: 0.33, 1.07). Daily maternal consumption of 400 μg of folic acid before and during early pregnancy may reduce the risk for imperforate anus.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>EISSN: 0002-9262</identifier><identifier>DOI: 10.1093/aje/154.11.1051</identifier><identifier>PMID: 11724722</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>abnormalities ; Adult ; anus ; Anus, Imperforate - epidemiology ; Anus, Imperforate - prevention & control ; Biological and medical sciences ; China - epidemiology ; confidence interval ; Female ; folic acid ; Folic Acid - administration & dosage ; Gastroenterology. Liver. Pancreas. Abdomen ; Health Promotion ; Humans ; imperforate ; Infant, Newborn ; Logistic Models ; Malformations ; Maternal Age ; Medical sciences ; Patient Compliance ; Pregnancy ; Pregnancy Outcome ; Prenatal Care ; primary prevention ; risk ; Risk Factors ; risk ratio ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tropical medicine</subject><ispartof>American journal of epidemiology, 2001-12, Vol.154 (11), p.1051-1056</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Dec 01, 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-2cc2db975ca1f151672cc78dd5d9a74dd3a287cfdc048fd2b8c34f4a770e01e43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14147015$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11724722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Myers, Melanie F.</creatorcontrib><creatorcontrib>Li, Song</creatorcontrib><creatorcontrib>Correa-Villaseñor, Adolfo</creatorcontrib><creatorcontrib>Li, Zhu</creatorcontrib><creatorcontrib>Moore, Cynthia A.</creatorcontrib><creatorcontrib>Hong, Shi Xin</creatorcontrib><creatorcontrib>Berry, Robert J.</creatorcontrib><creatorcontrib>China-US Collaborative Project for Neural Tube Defect Prevention</creatorcontrib><title>Folic Acid Supplementation and Risk for Imperforate Anus in China</title><title>American journal of epidemiology</title><addtitle>Am. J. Epidemiol</addtitle><description>Maternal consumption of folic acid before pregnancy and during early pregnancy is associated with a reduced risk for some birth defects. Whether folic acid can reduce the risk for imperforate anus is unknown. As part of a public health campaign conducted in China from 1993 through 1995, the outcomes of pregnancies of ≥20 weeks' gestation were evaluated among women using folic acid supplements. The women were asked to take one pill containing 400 μg of folic acid (without other vitamins) every day from the time of their premarital examination until the end of their first trimester of pregnancy. Rates of imperforate anus and risk ratios for imperforate anus among the offspring of these women were calculated according to folic acid use. Among the offspring of women who took folic acid and women who did not take folic acid, 20 and 30 infants with imperforate anus were identified, respectively. The rate of imperforate anus was 3.1 per 10,000 among the offspring of women who did not take folic acid and 1.6 per 10,000 among the offspring of women who took folic acid; adjusted for maternal age, the risk ratio was 0.59 (95% confidence interval: 0.33, 1.07). Daily maternal consumption of 400 μg of folic acid before and during early pregnancy may reduce the risk for imperforate anus.</description><subject>abnormalities</subject><subject>Adult</subject><subject>anus</subject><subject>Anus, Imperforate - epidemiology</subject><subject>Anus, Imperforate - prevention & control</subject><subject>Biological and medical sciences</subject><subject>China - epidemiology</subject><subject>confidence interval</subject><subject>Female</subject><subject>folic acid</subject><subject>Folic Acid - administration & dosage</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Health Promotion</subject><subject>Humans</subject><subject>imperforate</subject><subject>Infant, Newborn</subject><subject>Logistic Models</subject><subject>Malformations</subject><subject>Maternal Age</subject><subject>Medical sciences</subject><subject>Patient Compliance</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Prenatal Care</subject><subject>primary prevention</subject><subject>risk</subject><subject>Risk Factors</subject><subject>risk ratio</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tropical medicine</subject><issn>0002-9262</issn><issn>1476-6256</issn><issn>0002-9262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0dtr2zAUB2AxVtas2_Peihh0b250dLHsxxB6g6yFbmMjL0KRZKrUll3Jhva_r0JCC3vS7TuHw08IfQNyDqRmc711cxD8HCCfBXxAM-CyLEoqyo9oRgihRU1Leow-p7QlBKAW5BM6BpCUS0pnaHHZt97ghfEW_5qGoXWdC6MefR-wDhbf-_SImz7im25wMW_06PAiTAn7gJcPPugv6KjRbXJfD-sJ-nN58Xt5Xazurm6Wi1VhBOVjQY2hdlNLYTQ0IKCU-UZW1gpba8mtZZpW0jTWEF41lm4qw3jDtZTEEXCcnaAf-75D7J8ml0bV-WRc2-rg-ikpSVmuLFmG3_-D236KIc-mKBMVrziUGc33yMQ-pegaNUTf6fiigKhdtCpHq3K0CkDtos0Vp4e206Zz9t0fsszg7AB0Mrptog7Gp3fH89cQENkVe-fT6J7f3nV8VKVkUqjrf2v1k68E3K6J-steATDJjxs</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Myers, Melanie F.</creator><creator>Li, Song</creator><creator>Correa-Villaseñor, Adolfo</creator><creator>Li, Zhu</creator><creator>Moore, Cynthia A.</creator><creator>Hong, Shi Xin</creator><creator>Berry, Robert J.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>Folic Acid Supplementation and Risk for Imperforate Anus in China</title><author>Myers, Melanie F. ; Li, Song ; Correa-Villaseñor, Adolfo ; Li, Zhu ; Moore, Cynthia A. ; Hong, Shi Xin ; Berry, Robert J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-2cc2db975ca1f151672cc78dd5d9a74dd3a287cfdc048fd2b8c34f4a770e01e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>abnormalities</topic><topic>Adult</topic><topic>anus</topic><topic>Anus, Imperforate - epidemiology</topic><topic>Anus, Imperforate - prevention & control</topic><topic>Biological and medical sciences</topic><topic>China - epidemiology</topic><topic>confidence interval</topic><topic>Female</topic><topic>folic acid</topic><topic>Folic Acid - administration & dosage</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Health Promotion</topic><topic>Humans</topic><topic>imperforate</topic><topic>Infant, Newborn</topic><topic>Logistic Models</topic><topic>Malformations</topic><topic>Maternal Age</topic><topic>Medical sciences</topic><topic>Patient Compliance</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Prenatal Care</topic><topic>primary prevention</topic><topic>risk</topic><topic>Risk Factors</topic><topic>risk ratio</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Myers, Melanie F.</creatorcontrib><creatorcontrib>Li, Song</creatorcontrib><creatorcontrib>Correa-Villaseñor, Adolfo</creatorcontrib><creatorcontrib>Li, Zhu</creatorcontrib><creatorcontrib>Moore, Cynthia A.</creatorcontrib><creatorcontrib>Hong, Shi Xin</creatorcontrib><creatorcontrib>Berry, Robert J.</creatorcontrib><creatorcontrib>China-US Collaborative Project for Neural Tube Defect Prevention</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Myers, Melanie F.</au><au>Li, Song</au><au>Correa-Villaseñor, Adolfo</au><au>Li, Zhu</au><au>Moore, Cynthia A.</au><au>Hong, Shi Xin</au><au>Berry, Robert J.</au><aucorp>China-US Collaborative Project for Neural Tube Defect Prevention</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Folic Acid Supplementation and Risk for Imperforate Anus in China</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am. J. Epidemiol</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>154</volume><issue>11</issue><spage>1051</spage><epage>1056</epage><pages>1051-1056</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><eissn>0002-9262</eissn><coden>AJEPAS</coden><abstract>Maternal consumption of folic acid before pregnancy and during early pregnancy is associated with a reduced risk for some birth defects. Whether folic acid can reduce the risk for imperforate anus is unknown. As part of a public health campaign conducted in China from 1993 through 1995, the outcomes of pregnancies of ≥20 weeks' gestation were evaluated among women using folic acid supplements. The women were asked to take one pill containing 400 μg of folic acid (without other vitamins) every day from the time of their premarital examination until the end of their first trimester of pregnancy. Rates of imperforate anus and risk ratios for imperforate anus among the offspring of these women were calculated according to folic acid use. Among the offspring of women who took folic acid and women who did not take folic acid, 20 and 30 infants with imperforate anus were identified, respectively. The rate of imperforate anus was 3.1 per 10,000 among the offspring of women who did not take folic acid and 1.6 per 10,000 among the offspring of women who took folic acid; adjusted for maternal age, the risk ratio was 0.59 (95% confidence interval: 0.33, 1.07). Daily maternal consumption of 400 μg of folic acid before and during early pregnancy may reduce the risk for imperforate anus.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>11724722</pmid><doi>10.1093/aje/154.11.1051</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | abnormalities Adult anus Anus, Imperforate - epidemiology Anus, Imperforate - prevention & control Biological and medical sciences China - epidemiology confidence interval Female folic acid Folic Acid - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen Health Promotion Humans imperforate Infant, Newborn Logistic Models Malformations Maternal Age Medical sciences Patient Compliance Pregnancy Pregnancy Outcome Prenatal Care primary prevention risk Risk Factors risk ratio Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tropical medicine |
| title | Folic Acid Supplementation and Risk for Imperforate Anus in China |
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