Increased apoptosis of bone marrow CD34+ cells and impaired function of bone marrow stromal cells in patients with systemic lupus erythematosus

The changes in bone marrow (BM) stem cell reserve and function and stromal cell function in patients with active systemic lupus erythematosus (SLE) were investigated. The study was carried out on seven SLE patients and 28 healthy controls using flow cytometry and in vitro cell culture assays. We fou...

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Veröffentlicht in:	British journal of haematology 2001-10, Vol.115 (1), p.167-174
Hauptverfasser:	Papadaki, Helen A., Boumpas, Dimitrios T., Gibson, Frances M., Jayne, David R., Axford, John S., Gordon‐Smith, E. C., Marsh, Judith C. W., Eliopoulos, George D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Antigens, CD34 - analysis Apoptosis Biological and medical sciences Bone Marrow Cells - immunology Case-Control Studies CD34+ cells Cells, Cultured Colony-Forming Units Assay fas Receptor - analysis Female Flow Cytometry General aspects Hematology Hematopoiesis Hematopoietic Stem Cell Transplantation Humans Immunohistochemistry Immunopathology long‐term bone marrow cultures (LTBMCs) Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - surgery Male Medical sciences Middle Aged Statistics, Nonparametric Stem Cells - immunology stromal cells systemic lupus erythematosus (SLE) Time Factors
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