Ionic mechanism of delayed afterdepolarizations in ventricular cells isolated from human end-stage failing hearts

Animal studies have shown that the Ca(2+)-activated Cl(-) current (I(Cl(Ca))) and the Na(+)/Ca(2+) exchange current (I(Na/Ca)) contribute to the transient inward current (I(ti)). I(ti) is responsible for the proarrhythmic delayed afterdepolarizations (DADs). We investigated the ionic mechanism of I(...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2001-11, Vol.104 (22), p.2728-2733
Hauptverfasser:	VERKERK, Arie O, VELDKAMP, Marieke W, BAARTSCHEER, Antonius, SCHUMACHER, Cees A, KLÖPPING, Corinne, VAN GINNEKEN, Antoni C. G, RAVESLOOT, Jan H
Format:	Artikel
Sprache:	eng
Schlagworte:	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology Adult Animals Biological and medical sciences Calcium - metabolism Cardiology. Vascular system Cell Separation Chloride Channels - antagonists & inhibitors Disease Models, Animal Electric Stimulation Female Heart Heart Failure - pathology Heart Failure - physiopathology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Ventricles - drug effects Heart Ventricles - pathology Heart Ventricles - physiopathology Humans In Vitro Techniques Lithium - pharmacology Male Medical sciences Membrane Potentials - drug effects Middle Aged Norepinephrine - pharmacology Patch-Clamp Techniques Rabbits Sodium-Calcium Exchanger - antagonists & inhibitors
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