Combinatorial synthesis of CCR5 antagonists

Herein we report the preparation of a combinatorial library of compounds with potent CCR5 binding affinity. The library design was aided by SAR generated in a traditional medicinal chemistry effort. Compounds with novel combinations of subunits were discovered that have high binding affinity for the...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-12, Vol.11 (24), p.3137-3141
Hauptverfasser:	Willoughby, Christopher A, Berk, Scott C, Rosauer, Keith G, Degrado, Silvia, Chapman, Kevin T, Gould, Sandra L, Springer, Martin S, Malkowitz, Lorraine, Schleif, William A, Hazuda, Daria, Miller, Michael, Kessler, Joseph, Danzeisen, Renee, Holmes, Karen, Lineberger, Janet, Carella, Anthony, Carver, Gwen, Emini, Emilio A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CCR5 Receptor Antagonists Combinatorial Chemistry Techniques HIV-1 - drug effects Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship
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