Analgesic efficacy of ketorolac 0.5% ophthalmic solution (Accular) in paediatric strabismus surgery
This prospective double‐blind study was designed to assess the analgesic efficacy of ketorolac 0.5% ophthalmic solution compared with placebo in 30 healthy children undergoing extraocular muscle recession for correction of strabismus. After paracetamol 20 mg·kg–1 preoperatively, a standard anaesthet...
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| Veröffentlicht in: | Pediatric anesthesia 2000-09, Vol.10 (5), p.521-526 |
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| creator | Bridge, Hilary S. Montgomery, Carolyne J. Kennedy, Ross A. Merrick, Pamela M. |
| description | This prospective double‐blind study was designed to assess the analgesic efficacy of ketorolac 0.5% ophthalmic solution compared with placebo in 30 healthy children undergoing extraocular muscle recession for correction of strabismus. After paracetamol 20 mg·kg–1 preoperatively, a standard anaesthetic was given. There were no significant differences in Children’s Hospital of Eastern Ontario Pain Scale (CHEOPS) and faces pain scale (FPS) scores, requirement for supplementary analgesia or in postoperative vomiting between the two groups over the following 24 h. This study did not demonstrate improved postoperative analgesia when topical ketorolac eye drops were given in addition to paracetamol. This observed lack of efficacy may reflect difficulties in the use of CHEOPS and FPS in this age group with this pain model. |
| doi_str_mv | 10.1046/j.1460-9592.2000.00534.x |
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After paracetamol 20 mg·kg–1 preoperatively, a standard anaesthetic was given. There were no significant differences in Children’s Hospital of Eastern Ontario Pain Scale (CHEOPS) and faces pain scale (FPS) scores, requirement for supplementary analgesia or in postoperative vomiting between the two groups over the following 24 h. This study did not demonstrate improved postoperative analgesia when topical ketorolac eye drops were given in addition to paracetamol. This observed lack of efficacy may reflect difficulties in the use of CHEOPS and FPS in this age group with this pain model.</description><identifier>ISSN: 1155-5645</identifier><identifier>EISSN: 1460-9592</identifier><identifier>DOI: 10.1046/j.1460-9592.2000.00534.x</identifier><identifier>PMID: 11012956</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>analgesia: ketorolac ; Analgesics ; Biological and medical sciences ; Child ; Child, Preschool ; Double-Blind Method ; Female ; Humans ; incidence ; Ketorolac - administration & dosage ; Ketorolac - therapeutic use ; Male ; Medical sciences ; Neuropharmacology ; Ophthalmic Solutions ; Ophthalmologic Surgical Procedures ; Pain Measurement ; Pain, Postoperative - drug therapy ; Pain, Postoperative - epidemiology ; pain: postoperative ; pain: postoperative, scores ; Pharmacology. Drug treatments ; Postoperative Nausea and Vomiting - epidemiology ; scores ; Strabismus - surgery ; surgery: strabismus ; vomiting: postoperative ; vomiting: postoperative, incidence</subject><ispartof>Pediatric anesthesia, 2000-09, Vol.10 (5), p.521-526</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4314-643c86a6d7b25a3681de7e74f5385eb9fad5374c683ecf010f7121809b0d79a13</citedby><cites>FETCH-LOGICAL-c4314-643c86a6d7b25a3681de7e74f5385eb9fad5374c683ecf010f7121809b0d79a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1460-9592.2000.00534.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1460-9592.2000.00534.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1482529$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11012956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bridge, Hilary S.</creatorcontrib><creatorcontrib>Montgomery, Carolyne J.</creatorcontrib><creatorcontrib>Kennedy, Ross A.</creatorcontrib><creatorcontrib>Merrick, Pamela M.</creatorcontrib><title>Analgesic efficacy of ketorolac 0.5% ophthalmic solution (Accular) in paediatric strabismus surgery</title><title>Pediatric anesthesia</title><addtitle>Paediatr Anaesth</addtitle><description>This prospective double‐blind study was designed to assess the analgesic efficacy of ketorolac 0.5% ophthalmic solution compared with placebo in 30 healthy children undergoing extraocular muscle recession for correction of strabismus. After paracetamol 20 mg·kg–1 preoperatively, a standard anaesthetic was given. There were no significant differences in Children’s Hospital of Eastern Ontario Pain Scale (CHEOPS) and faces pain scale (FPS) scores, requirement for supplementary analgesia or in postoperative vomiting between the two groups over the following 24 h. This study did not demonstrate improved postoperative analgesia when topical ketorolac eye drops were given in addition to paracetamol. This observed lack of efficacy may reflect difficulties in the use of CHEOPS and FPS in this age group with this pain model.</description><subject>analgesia: ketorolac</subject><subject>Analgesics</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>incidence</subject><subject>Ketorolac - administration & dosage</subject><subject>Ketorolac - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Ophthalmic Solutions</subject><subject>Ophthalmologic Surgical Procedures</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pain, Postoperative - epidemiology</subject><subject>pain: postoperative</subject><subject>pain: postoperative, scores</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Nausea and Vomiting - epidemiology</subject><subject>scores</subject><subject>Strabismus - surgery</subject><subject>surgery: strabismus</subject><subject>vomiting: postoperative</subject><subject>vomiting: postoperative, incidence</subject><issn>1155-5645</issn><issn>1460-9592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0Eou3CX0A-ACqHBH_HkbisKihIq1Khoh6tiWO33jqbrZ2I3X9Pwq7aK6cZaZ53XulBCFNSUiLU53VJhSJFLWtWMkJISYjkoty9QKdPh5fTTqUspBLyBJ3lvCaEcqbYa3RCKaGsluoU2eUG4p3LwWLnfbBg97j3-MENfeojWExK-QH32_vhHmI3UbmP4xD6DT5fWjtGSJ9w2OAtuDbAkGZgSNCE3I0Z5zHdubR_g155iNm9Pc4F-v3t683F92L18_LHxXJVWMGpKJTgVitQbdUwCVxp2rrKVcJLrqVrag-t5JWwSnNnPaHEV5RRTeqGtFUNlC_Qx8PfbeofR5cH04VsXYywcf2YTcU44WKqWSB9AG3qc07Om20KHaS9ocTMgs3azB7N7NHMgs0_wWY3Rd8dO8amc-1z8Gh0At4fAcgWok-wsSE_c0IzyeoJ-3LA_oTo9v_db66XV9MyxYtDPOTB7Z7ikB6Mqnglze3Vpfm1Elpf39wazf8CTfukuA</recordid><startdate>200009</startdate><enddate>200009</enddate><creator>Bridge, Hilary S.</creator><creator>Montgomery, Carolyne J.</creator><creator>Kennedy, Ross A.</creator><creator>Merrick, Pamela M.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200009</creationdate><title>Analgesic efficacy of ketorolac 0.5% ophthalmic solution (Accular) in paediatric strabismus surgery</title><author>Bridge, Hilary S. ; Montgomery, Carolyne J. ; Kennedy, Ross A. ; Merrick, Pamela M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4314-643c86a6d7b25a3681de7e74f5385eb9fad5374c683ecf010f7121809b0d79a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>analgesia: ketorolac</topic><topic>Analgesics</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>incidence</topic><topic>Ketorolac - administration & dosage</topic><topic>Ketorolac - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Ophthalmic Solutions</topic><topic>Ophthalmologic Surgical Procedures</topic><topic>Pain Measurement</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Pain, Postoperative - epidemiology</topic><topic>pain: postoperative</topic><topic>pain: postoperative, scores</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Nausea and Vomiting - epidemiology</topic><topic>scores</topic><topic>Strabismus - surgery</topic><topic>surgery: strabismus</topic><topic>vomiting: postoperative</topic><topic>vomiting: postoperative, incidence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bridge, Hilary S.</creatorcontrib><creatorcontrib>Montgomery, Carolyne J.</creatorcontrib><creatorcontrib>Kennedy, Ross A.</creatorcontrib><creatorcontrib>Merrick, Pamela M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bridge, Hilary S.</au><au>Montgomery, Carolyne J.</au><au>Kennedy, Ross A.</au><au>Merrick, Pamela M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesic efficacy of ketorolac 0.5% ophthalmic solution (Accular) in paediatric strabismus surgery</atitle><jtitle>Pediatric anesthesia</jtitle><addtitle>Paediatr Anaesth</addtitle><date>2000-09</date><risdate>2000</risdate><volume>10</volume><issue>5</issue><spage>521</spage><epage>526</epage><pages>521-526</pages><issn>1155-5645</issn><eissn>1460-9592</eissn><abstract>This prospective double‐blind study was designed to assess the analgesic efficacy of ketorolac 0.5% ophthalmic solution compared with placebo in 30 healthy children undergoing extraocular muscle recession for correction of strabismus. After paracetamol 20 mg·kg–1 preoperatively, a standard anaesthetic was given. There were no significant differences in Children’s Hospital of Eastern Ontario Pain Scale (CHEOPS) and faces pain scale (FPS) scores, requirement for supplementary analgesia or in postoperative vomiting between the two groups over the following 24 h. This study did not demonstrate improved postoperative analgesia when topical ketorolac eye drops were given in addition to paracetamol. This observed lack of efficacy may reflect difficulties in the use of CHEOPS and FPS in this age group with this pain model.</abstract><cop>Oxford UK</cop><pub>Blackwell Science Ltd</pub><pmid>11012956</pmid><doi>10.1046/j.1460-9592.2000.00534.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Pediatric anesthesia, 2000-09, Vol.10 (5), p.521-526 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | analgesia: ketorolac Analgesics Biological and medical sciences Child Child, Preschool Double-Blind Method Female Humans incidence Ketorolac - administration & dosage Ketorolac - therapeutic use Male Medical sciences Neuropharmacology Ophthalmic Solutions Ophthalmologic Surgical Procedures Pain Measurement Pain, Postoperative - drug therapy Pain, Postoperative - epidemiology pain: postoperative pain: postoperative, scores Pharmacology. Drug treatments Postoperative Nausea and Vomiting - epidemiology scores Strabismus - surgery surgery: strabismus vomiting: postoperative vomiting: postoperative, incidence |
| title | Analgesic efficacy of ketorolac 0.5% ophthalmic solution (Accular) in paediatric strabismus surgery |
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