Antibodies to the Major Linear Neutralizing Domains of Cytomegalovirus Glycoprotein B Among Natural Seropositives and CMV Subunit Vaccine Recipients

The gB protein (gpUL55) of human cytomegalovirus (CMV) contains C-terminal (AD-1) and N-terminal (AD-2) linear immunodominant neutralizing domains. To measure antibodies to these epitopes, a modified protein (Δ-gB) lacking heavily glycosylated intervening regions, the transmembrane domain, and the c...

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Veröffentlicht in:	Viral immunology 2000-01, Vol.13 (3), p.329-341
Hauptverfasser:	Marshall, Gary S., Li, Mengtao, Stout, Gordon G., Louthan, Miriam V., Duliège, Anne-Marie, Burke, Rae Lyn, Hunt, Lawrence A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Viral - blood Antibodies, Viral - immunology Baculoviridae - genetics Baculovirus Cytomegalovirus Cytomegalovirus - immunology Cytomegalovirus Infections - immunology Cytomegalovirus Infections - virology Cytomegalovirus Vaccines - immunology Enzyme-Linked Immunosorbent Assay glycoprotein B Human cytomegalovirus Humans Neutralization Tests Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - metabolism Vaccines, Subunit - immunology Viral Envelope Proteins - chemistry Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology
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