Grb3-3 Is Up-regulated in HIV-1-infected T-cells and Can Potentiate Cell Activation through NFATc

The MAPK pathway is required for T-cell activation; however, its role in modulating T-cell function following human immunodeficiency virus type 1 (HIV-1) infection is poorly understood. In this report, we investigated whether Grb3-3, an isoform of the Grb2 (growth factorreceptor-bound protein-2) ada...

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Veröffentlicht in:	The Journal of biological chemistry 2000-10, Vol.275 (40), p.30925-30933
Hauptverfasser:	Li, Xuguang, Multon, Marie-Christine, Henin, Yvette, Schweighoffer, Fabien, Venot, Corinne, Josef, Juliana, Zhou, Changhong, LaVecchio, Joyce, Stuckert, Patricia, Raab, Monika, Mhashilkar, Abner, Tocqué, Bruno, Marasco, Wayne A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adult Antibodies, Monoclonal - metabolism Blotting, Western CD28 Antigens - metabolism CD4 antigen CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology Cell Nucleus - metabolism Cyclosporine - pharmacology Cytoplasm - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Gene Products, nef - metabolism Gene Products, tat - metabolism GRB2 Adaptor Protein Grb3-3 protein HIV Infections - metabolism HIV-1 - metabolism human immunodeficiency virus 1 Humans Immunosuppressive Agents - pharmacology Jurkat Cells Leukocytes, Mononuclear - virology Luciferases - metabolism Male MAP Kinase Kinase Kinase 1 MAP Kinase Signaling System Middle Aged nef Gene Products, Human Immunodeficiency Virus NF-AT protein NFATC Transcription Factors Nuclear Proteins Plasmids - metabolism Promoter Regions, Genetic Protein Isoforms Protein-Serine-Threonine Kinases - metabolism Proteins - chemistry Proteins - genetics Proteins - metabolism Receptors, Antigen, T-Cell - metabolism RNA, Messenger - metabolism Signal Transduction tat Gene Products, Human Immunodeficiency Virus Terminal Repeat Sequences Time Factors Transcription Factor AP-1 - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transfection Up-Regulation
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