Cyclic nucleotide analogs as biochemical tools and prospective drugs

Cyclic AMP (cAMP) and cyclic GMP (cGMP) are key second messengers involved in a multitude of cellular events. From the wealth of synthetic analogs of cAMP and cGMP, only a few have been explored with regard to their therapeutic potential. Some of the first-generation cyclic nucleotide analogs were p...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 2000-08, Vol.87 (2), p.199-226
Hauptverfasser:	Schwede, Frank, Maronde, Erik, Genieser, Hans-Gottfried, Jastorff, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Chloro cyclic AMP Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Asthma - drug therapy cAMP-dependent protein kinase cGMP-dependent protein kinase Clinical studies Clinical Trials as Topic Cyclic AMP-Dependent Protein Kinases - metabolism Cyclic AMP-Dependent Protein Kinases - pharmacokinetics Cyclic AMP-Dependent Protein Kinases - therapeutic use Cyclic GMP - physiology Cyclic GMP-Dependent Protein Kinases - metabolism Cyclic GMP-Dependent Protein Kinases - pharmacokinetics Cyclic GMP-Dependent Protein Kinases - therapeutic use Cyclic nucleotide analogs Humans Hypertension - drug therapy Neoplasms - drug therapy Receptors, Cyclic AMP - physiology Signal Transduction
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