Perfluorochemical elimination from the lungs: Effect of initial dose
Liquid‐assisted ventilation with perfluorochemical (PFC) has been beneficial in a variety of respiratory diseases in animals and humans. Although PFC evaporation from the lungs is in part dependent on ventilation strategy and positioning, guidelines for initial and replacement dosing are unclear. We...
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Veröffentlicht in: | Pediatric pulmonology 2000-10, Vol.30 (4), p.324-329 |
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description | Liquid‐assisted ventilation with perfluorochemical (PFC) has been beneficial in a variety of respiratory diseases in animals and humans. Although PFC evaporation from the lungs is in part dependent on ventilation strategy and positioning, guidelines for initial and replacement dosing are unclear. We hypothesized that PFC evaporative loss over time is dependent on the size of the initial dose. Juvenile rabbits (n = 18) were ventilated using constant animal position and ventilator strategy. PFC (perflubron: LiquiVent ) was instilled endotracheally, using four groups with initial doses of 2, 6, 12, and 17 mL/kg. A previously described thermal detector that measures PFC in expired gas was used to calculate loss rate, residual perflubron in the lung, and volume loss as a % of initial fill volume.
There was a significant dose, time, and dose–time interaction such that evaporative loss was dependent on initial PFC volume and time after fill (P < 0.05). Evaporative loss rate decreased earlier at lower doses. The percentage of initial volume lost to evaporation over time was inversely related to dose and could not be predicted by decreasing % PFC saturations, independent of dose.
Evaporative loss should be considered to optimize both the application of PFC to the lung and replacement dosing during partial liquid ventilation. Pediatr Pulmonol. 2000; 30:324–329 © 2000 Wiley‐Liss, Inc. |
doi_str_mv | 10.1002/1099-0496(200010)30:4<324::AID-PPUL9>3.0.CO;2-7 |
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There was a significant dose, time, and dose–time interaction such that evaporative loss was dependent on initial PFC volume and time after fill (P < 0.05). Evaporative loss rate decreased earlier at lower doses. The percentage of initial volume lost to evaporation over time was inversely related to dose and could not be predicted by decreasing % PFC saturations, independent of dose.
Evaporative loss should be considered to optimize both the application of PFC to the lung and replacement dosing during partial liquid ventilation. Pediatr Pulmonol. 2000; 30:324–329 © 2000 Wiley‐Liss, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/1099-0496(200010)30:4<324::AID-PPUL9>3.0.CO;2-7</identifier><identifier>PMID: 11015134</identifier><identifier>CODEN: PEPUES</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; animal studies ; Animals ; Biological and medical sciences ; Emergency and intensive respiratory care ; evaporative loss ; Fluorocarbons - administration & dosage ; Fluorocarbons - pharmacokinetics ; Furans - administration & dosage ; Furans - pharmacokinetics ; Intensive care medicine ; Lung - metabolism ; Medical sciences ; partial liquid ventilation ; perfluorochemical ; PFC dosing ; Rabbits ; Respiration, Artificial ; Tidal Volume</subject><ispartof>Pediatric pulmonology, 2000-10, Vol.30 (4), p.324-329</ispartof><rights>Copyright © 2000 Wiley‐Liss, Inc.</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2000 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4199-301e5f7a5693e744afb1748a0db6647a4f5c53c0e66bcc3ed9736ef00730185a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1099-0496%28200010%2930%3A4%3C324%3A%3AAID-PPUL9%3E3.0.CO%3B2-7$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1099-0496%28200010%2930%3A4%3C324%3A%3AAID-PPUL9%3E3.0.CO%3B2-7$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=788858$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11015134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weis, Carla M.</creatorcontrib><creatorcontrib>Fox, William W.</creatorcontrib><creatorcontrib>Philips, Charles M.</creatorcontrib><creatorcontrib>Wolfson, Marla R.</creatorcontrib><creatorcontrib>Shaffer, Thomas H.</creatorcontrib><title>Perfluorochemical elimination from the lungs: Effect of initial dose</title><title>Pediatric pulmonology</title><addtitle>Pediatr. Pulmonol</addtitle><description>Liquid‐assisted ventilation with perfluorochemical (PFC) has been beneficial in a variety of respiratory diseases in animals and humans. Although PFC evaporation from the lungs is in part dependent on ventilation strategy and positioning, guidelines for initial and replacement dosing are unclear. We hypothesized that PFC evaporative loss over time is dependent on the size of the initial dose. Juvenile rabbits (n = 18) were ventilated using constant animal position and ventilator strategy. PFC (perflubron: LiquiVent ) was instilled endotracheally, using four groups with initial doses of 2, 6, 12, and 17 mL/kg. A previously described thermal detector that measures PFC in expired gas was used to calculate loss rate, residual perflubron in the lung, and volume loss as a % of initial fill volume.
There was a significant dose, time, and dose–time interaction such that evaporative loss was dependent on initial PFC volume and time after fill (P < 0.05). Evaporative loss rate decreased earlier at lower doses. The percentage of initial volume lost to evaporation over time was inversely related to dose and could not be predicted by decreasing % PFC saturations, independent of dose.
Evaporative loss should be considered to optimize both the application of PFC to the lung and replacement dosing during partial liquid ventilation. Pediatr Pulmonol. 2000; 30:324–329 © 2000 Wiley‐Liss, Inc.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>animal studies</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive respiratory care</subject><subject>evaporative loss</subject><subject>Fluorocarbons - administration & dosage</subject><subject>Fluorocarbons - pharmacokinetics</subject><subject>Furans - administration & dosage</subject><subject>Furans - pharmacokinetics</subject><subject>Intensive care medicine</subject><subject>Lung - metabolism</subject><subject>Medical sciences</subject><subject>partial liquid ventilation</subject><subject>perfluorochemical</subject><subject>PFC dosing</subject><subject>Rabbits</subject><subject>Respiration, Artificial</subject><subject>Tidal Volume</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF2LEzEUQAdR3Lr6F2RAEH2YejP5mlQRlu66LlRbwbWyL5c0Tdys87EmM-j-e1On1BdffApczj25nCyTBKYEoHxFQKkCmBIvSgAg8JLCjL2hJZvNTi5Oi9XqcqHe0ilM58vXZSHvZZPDxv1sUknOC1EJepQ9ivEmGZRS5GF2RAgQTiibZKcrG1w9dKEz17bxRte5rX3jW937rs1d6Jq8v7Z5PbTf4iw_c86aPu9c7lvf-0Rvu2gfZw-crqN9sn-Ps8t3Z5_n74vF8vxifrIoDCPpKgrEcic1F4payZh2GyJZpWG7EYJJzRw3nBqwQmyMoXarJBXWAci0WXFNj7Pno_c2dD8GG3tsfDS2rnVruyGiLEulypIlcDmCJnQxBuvwNvhGhzskgLuwuMuEu0w4hkUKyDCFRUxh8U9YpAg4X2KJMhmf7r8eNo3d_vXtSybg2R7QMVV0QbfGxwMnq6riVaI-jdRPX9u7_7jqX0eNg-QsRqePvf11cOrwHYWkkuP64znKD1-u1l-vCK7pbwMhq7E</recordid><startdate>200010</startdate><enddate>200010</enddate><creator>Weis, Carla M.</creator><creator>Fox, William W.</creator><creator>Philips, Charles M.</creator><creator>Wolfson, Marla R.</creator><creator>Shaffer, Thomas H.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200010</creationdate><title>Perfluorochemical elimination from the lungs: Effect of initial dose</title><author>Weis, Carla M. ; Fox, William W. ; Philips, Charles M. ; Wolfson, Marla R. ; Shaffer, Thomas H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4199-301e5f7a5693e744afb1748a0db6647a4f5c53c0e66bcc3ed9736ef00730185a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>animal studies</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive respiratory care</topic><topic>evaporative loss</topic><topic>Fluorocarbons - administration & dosage</topic><topic>Fluorocarbons - pharmacokinetics</topic><topic>Furans - administration & dosage</topic><topic>Furans - pharmacokinetics</topic><topic>Intensive care medicine</topic><topic>Lung - metabolism</topic><topic>Medical sciences</topic><topic>partial liquid ventilation</topic><topic>perfluorochemical</topic><topic>PFC dosing</topic><topic>Rabbits</topic><topic>Respiration, Artificial</topic><topic>Tidal Volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weis, Carla M.</creatorcontrib><creatorcontrib>Fox, William W.</creatorcontrib><creatorcontrib>Philips, Charles M.</creatorcontrib><creatorcontrib>Wolfson, Marla R.</creatorcontrib><creatorcontrib>Shaffer, Thomas H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weis, Carla M.</au><au>Fox, William W.</au><au>Philips, Charles M.</au><au>Wolfson, Marla R.</au><au>Shaffer, Thomas H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perfluorochemical elimination from the lungs: Effect of initial dose</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. Pulmonol</addtitle><date>2000-10</date><risdate>2000</risdate><volume>30</volume><issue>4</issue><spage>324</spage><epage>329</epage><pages>324-329</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><coden>PEPUES</coden><abstract>Liquid‐assisted ventilation with perfluorochemical (PFC) has been beneficial in a variety of respiratory diseases in animals and humans. Although PFC evaporation from the lungs is in part dependent on ventilation strategy and positioning, guidelines for initial and replacement dosing are unclear. We hypothesized that PFC evaporative loss over time is dependent on the size of the initial dose. Juvenile rabbits (n = 18) were ventilated using constant animal position and ventilator strategy. PFC (perflubron: LiquiVent ) was instilled endotracheally, using four groups with initial doses of 2, 6, 12, and 17 mL/kg. A previously described thermal detector that measures PFC in expired gas was used to calculate loss rate, residual perflubron in the lung, and volume loss as a % of initial fill volume.
There was a significant dose, time, and dose–time interaction such that evaporative loss was dependent on initial PFC volume and time after fill (P < 0.05). Evaporative loss rate decreased earlier at lower doses. The percentage of initial volume lost to evaporation over time was inversely related to dose and could not be predicted by decreasing % PFC saturations, independent of dose.
Evaporative loss should be considered to optimize both the application of PFC to the lung and replacement dosing during partial liquid ventilation. Pediatr Pulmonol. 2000; 30:324–329 © 2000 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11015134</pmid><doi>10.1002/1099-0496(200010)30:4<324::AID-PPUL9>3.0.CO;2-7</doi><tpages>6</tpages></addata></record> |
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subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy animal studies Animals Biological and medical sciences Emergency and intensive respiratory care evaporative loss Fluorocarbons - administration & dosage Fluorocarbons - pharmacokinetics Furans - administration & dosage Furans - pharmacokinetics Intensive care medicine Lung - metabolism Medical sciences partial liquid ventilation perfluorochemical PFC dosing Rabbits Respiration, Artificial Tidal Volume |
title | Perfluorochemical elimination from the lungs: Effect of initial dose |
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