Perfluorochemical elimination from the lungs: Effect of initial dose

Liquid‐assisted ventilation with perfluorochemical (PFC) has been beneficial in a variety of respiratory diseases in animals and humans. Although PFC evaporation from the lungs is in part dependent on ventilation strategy and positioning, guidelines for initial and replacement dosing are unclear. We...

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Veröffentlicht in:Pediatric pulmonology 2000-10, Vol.30 (4), p.324-329
Hauptverfasser: Weis, Carla M., Fox, William W., Philips, Charles M., Wolfson, Marla R., Shaffer, Thomas H.
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container_start_page 324
container_title Pediatric pulmonology
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creator Weis, Carla M.
Fox, William W.
Philips, Charles M.
Wolfson, Marla R.
Shaffer, Thomas H.
description Liquid‐assisted ventilation with perfluorochemical (PFC) has been beneficial in a variety of respiratory diseases in animals and humans. Although PFC evaporation from the lungs is in part dependent on ventilation strategy and positioning, guidelines for initial and replacement dosing are unclear. We hypothesized that PFC evaporative loss over time is dependent on the size of the initial dose. Juvenile rabbits (n = 18) were ventilated using constant animal position and ventilator strategy. PFC (perflubron: LiquiVent ) was instilled endotracheally, using four groups with initial doses of 2, 6, 12, and 17 mL/kg. A previously described thermal detector that measures PFC in expired gas was used to calculate loss rate, residual perflubron in the lung, and volume loss as a % of initial fill volume. There was a significant dose, time, and dose–time interaction such that evaporative loss was dependent on initial PFC volume and time after fill (P < 0.05). Evaporative loss rate decreased earlier at lower doses. The percentage of initial volume lost to evaporation over time was inversely related to dose and could not be predicted by decreasing % PFC saturations, independent of dose. Evaporative loss should be considered to optimize both the application of PFC to the lung and replacement dosing during partial liquid ventilation. Pediatr Pulmonol. 2000; 30:324–329 © 2000 Wiley‐Liss, Inc.
doi_str_mv 10.1002/1099-0496(200010)30:4<324::AID-PPUL9>3.0.CO;2-7
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Pulmonol</addtitle><description>Liquid‐assisted ventilation with perfluorochemical (PFC) has been beneficial in a variety of respiratory diseases in animals and humans. Although PFC evaporation from the lungs is in part dependent on ventilation strategy and positioning, guidelines for initial and replacement dosing are unclear. We hypothesized that PFC evaporative loss over time is dependent on the size of the initial dose. Juvenile rabbits (n = 18) were ventilated using constant animal position and ventilator strategy. PFC (perflubron: LiquiVent ) was instilled endotracheally, using four groups with initial doses of 2, 6, 12, and 17 mL/kg. A previously described thermal detector that measures PFC in expired gas was used to calculate loss rate, residual perflubron in the lung, and volume loss as a % of initial fill volume. There was a significant dose, time, and dose–time interaction such that evaporative loss was dependent on initial PFC volume and time after fill (P &lt; 0.05). 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Cell therapy and gene therapy</subject><subject>animal studies</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive respiratory care</subject><subject>evaporative loss</subject><subject>Fluorocarbons - administration &amp; dosage</subject><subject>Fluorocarbons - pharmacokinetics</subject><subject>Furans - administration &amp; dosage</subject><subject>Furans - pharmacokinetics</subject><subject>Intensive care medicine</subject><subject>Lung - metabolism</subject><subject>Medical sciences</subject><subject>partial liquid ventilation</subject><subject>perfluorochemical</subject><subject>PFC dosing</subject><subject>Rabbits</subject><subject>Respiration, Artificial</subject><subject>Tidal Volume</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF2LEzEUQAdR3Lr6F2RAEH2YejP5mlQRlu66LlRbwbWyL5c0Tdys87EmM-j-e1On1BdffApczj25nCyTBKYEoHxFQKkCmBIvSgAg8JLCjL2hJZvNTi5Oi9XqcqHe0ilM58vXZSHvZZPDxv1sUknOC1EJepQ9ivEmGZRS5GF2RAgQTiibZKcrG1w9dKEz17bxRte5rX3jW937rs1d6Jq8v7Z5PbTf4iw_c86aPu9c7lvf-0Rvu2gfZw-crqN9sn-Ps8t3Z5_n74vF8vxifrIoDCPpKgrEcic1F4payZh2GyJZpWG7EYJJzRw3nBqwQmyMoXarJBXWAci0WXFNj7Pno_c2dD8GG3tsfDS2rnVruyGiLEulypIlcDmCJnQxBuvwNvhGhzskgLuwuMuEu0w4hkUKyDCFRUxh8U9YpAg4X2KJMhmf7r8eNo3d_vXtSybg2R7QMVV0QbfGxwMnq6riVaI-jdRPX9u7_7jqX0eNg-QsRqePvf11cOrwHYWkkuP64znKD1-u1l-vCK7pbwMhq7E</recordid><startdate>200010</startdate><enddate>200010</enddate><creator>Weis, Carla M.</creator><creator>Fox, William W.</creator><creator>Philips, Charles M.</creator><creator>Wolfson, Marla R.</creator><creator>Shaffer, Thomas H.</creator><general>John Wiley &amp; Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200010</creationdate><title>Perfluorochemical elimination from the lungs: Effect of initial dose</title><author>Weis, Carla M. ; Fox, William W. ; Philips, Charles M. ; Wolfson, Marla R. ; Shaffer, Thomas H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4199-301e5f7a5693e744afb1748a0db6647a4f5c53c0e66bcc3ed9736ef00730185a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Anesthesia. 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Cell therapy and gene therapy</topic><topic>animal studies</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive respiratory care</topic><topic>evaporative loss</topic><topic>Fluorocarbons - administration &amp; dosage</topic><topic>Fluorocarbons - pharmacokinetics</topic><topic>Furans - administration &amp; dosage</topic><topic>Furans - pharmacokinetics</topic><topic>Intensive care medicine</topic><topic>Lung - metabolism</topic><topic>Medical sciences</topic><topic>partial liquid ventilation</topic><topic>perfluorochemical</topic><topic>PFC dosing</topic><topic>Rabbits</topic><topic>Respiration, Artificial</topic><topic>Tidal Volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weis, Carla M.</creatorcontrib><creatorcontrib>Fox, William W.</creatorcontrib><creatorcontrib>Philips, Charles M.</creatorcontrib><creatorcontrib>Wolfson, Marla R.</creatorcontrib><creatorcontrib>Shaffer, Thomas H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weis, Carla M.</au><au>Fox, William W.</au><au>Philips, Charles M.</au><au>Wolfson, Marla R.</au><au>Shaffer, Thomas H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perfluorochemical elimination from the lungs: Effect of initial dose</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. 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subjects Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
animal studies
Animals
Biological and medical sciences
Emergency and intensive respiratory care
evaporative loss
Fluorocarbons - administration & dosage
Fluorocarbons - pharmacokinetics
Furans - administration & dosage
Furans - pharmacokinetics
Intensive care medicine
Lung - metabolism
Medical sciences
partial liquid ventilation
perfluorochemical
PFC dosing
Rabbits
Respiration, Artificial
Tidal Volume
title Perfluorochemical elimination from the lungs: Effect of initial dose
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