Skin microvascular adaptations during maturation and aging of hairless mice
Institute for Clinical and Experimental Surgery, University of Saarland, D-66421 Homburg/Saar, Germany Using intravital fluorescence microscopy in the ears of hairless mice, we determined skin microvascular adaptations during the process of aging from juvenile to adult and senescent life (6-78 wk)....
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2000-10, Vol.279 (4), p.H1591-H1599 |
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| container_issue | 4 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 279 |
| creator | Vollmar, Brigitte Morgenthaler, Martin Amon, Michaela Menger, Michael D |
| description | Institute for Clinical and Experimental Surgery, University of
Saarland, D-66421 Homburg/Saar, Germany
Using intravital fluorescence microscopy in the ears of
hairless mice, we determined skin microvascular adaptations during the
process of aging from juvenile to adult and senescent life (6-78
wk). Despite an increase of ear area within the first 36 wk,
the number and branching pattern of both arteriolar and venular microvessels remained constant during the whole life period. Both arterioles and venules exhibited an increase in length, diameter, and
intervascular distance up to the age of 36 wk. With the increase of the
size of the ears, the observation that cutaneous capillary density
remained unchanged implied new capillary formation. During aging to 78 wk, capillary density in the ears was reduced to ~40%. Functional
analysis revealed an appropriate hyperemic response to a 2-min period
of ischemia during late juvenile and adult life, which, however, was
markedly reduced during senescence. Thus, except for capillaries, there
is no indication for age-related new vessel formation. The process of
aging from adult to senescent life does not cause any significant
remodeling but is associated with a decrease of nutritive perfusion and
a functional impairment to respond to stimuli such as ischemia.
growth; tortuosity; elongation; intervascular distance; capillary
density |
| doi_str_mv | 10.1152/ajpheart.2000.279.4.h1591 |
| format | Article |
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Saarland, D-66421 Homburg/Saar, Germany
Using intravital fluorescence microscopy in the ears of
hairless mice, we determined skin microvascular adaptations during the
process of aging from juvenile to adult and senescent life (6-78
wk). Despite an increase of ear area within the first 36 wk,
the number and branching pattern of both arteriolar and venular microvessels remained constant during the whole life period. Both arterioles and venules exhibited an increase in length, diameter, and
intervascular distance up to the age of 36 wk. With the increase of the
size of the ears, the observation that cutaneous capillary density
remained unchanged implied new capillary formation. During aging to 78 wk, capillary density in the ears was reduced to ~40%. Functional
analysis revealed an appropriate hyperemic response to a 2-min period
of ischemia during late juvenile and adult life, which, however, was
markedly reduced during senescence. Thus, except for capillaries, there
is no indication for age-related new vessel formation. The process of
aging from adult to senescent life does not cause any significant
remodeling but is associated with a decrease of nutritive perfusion and
a functional impairment to respond to stimuli such as ischemia.
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Saarland, D-66421 Homburg/Saar, Germany
Using intravital fluorescence microscopy in the ears of
hairless mice, we determined skin microvascular adaptations during the
process of aging from juvenile to adult and senescent life (6-78
wk). Despite an increase of ear area within the first 36 wk,
the number and branching pattern of both arteriolar and venular microvessels remained constant during the whole life period. Both arterioles and venules exhibited an increase in length, diameter, and
intervascular distance up to the age of 36 wk. With the increase of the
size of the ears, the observation that cutaneous capillary density
remained unchanged implied new capillary formation. During aging to 78 wk, capillary density in the ears was reduced to ~40%. Functional
analysis revealed an appropriate hyperemic response to a 2-min period
of ischemia during late juvenile and adult life, which, however, was
markedly reduced during senescence. Thus, except for capillaries, there
is no indication for age-related new vessel formation. The process of
aging from adult to senescent life does not cause any significant
remodeling but is associated with a decrease of nutritive perfusion and
a functional impairment to respond to stimuli such as ischemia.
growth; tortuosity; elongation; intervascular distance; capillary
density</description><subject>Adaptation, Physiological</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Arterioles - growth & development</subject><subject>Arterioles - physiology</subject><subject>Capillaries - physiology</subject><subject>Ear - blood supply</subject><subject>Hyperemia - etiology</subject><subject>Hyperemia - physiopathology</subject><subject>Ischemia - complications</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Hairless - growth & development</subject><subject>Mice, Hairless - physiology</subject><subject>Microcirculation - physiology</subject><subject>Oxygen - blood</subject><subject>Skin - blood supply</subject><subject>Venules - growth & development</subject><subject>Venules - physiology</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1P3DAQhq0K1F1o_0IVLtyS9Th2shanalU-BBKHbs_WxHES03zVTij770nYpcChJ0vj531H8xByBjQCEGyFD31l0A0Ro5RGLJURjyoQEj6R5fTPQhCxPCJLGidxmEAsFuTE-4cJFmkSfyYLAEol52JJbn_-tm3QWO26R_R6rNEFmGM_4GC71gf56GxbBg0Oo3sZBdjmAZbzsCuCCq2rjfdzg_lCjgusvfl6eE_Jr8sf2811eHd_dbP5fhdqTsUQGjAFAi1QsjUw0LzQnBU6o6k2bK3jnJosWWtJmRQIOstyDTxJTY6QJBpZfErO97296_6Mxg-qsV6busbWdKNXKWNynXIxgXIPTtd570yhemcbdDsFVM0m1atJNZtUk0nF1fVscsp-OywZs8bkb8mDuglY7YHKltVf64zqq523Xd2Vu3e9Hyov_p-4HOt6a56Gf9F3SdXnRfwM0nqaZQ</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Vollmar, Brigitte</creator><creator>Morgenthaler, Martin</creator><creator>Amon, Michaela</creator><creator>Menger, Michael D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Skin microvascular adaptations during maturation and aging of hairless mice</title><author>Vollmar, Brigitte ; Morgenthaler, Martin ; Amon, Michaela ; Menger, Michael D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-e1efa10fa928121c4fc42fcb07ce28c3d0eb68c90295a1cbbdc1467eda166ca23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adaptation, Physiological</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Arterioles - growth & development</topic><topic>Arterioles - physiology</topic><topic>Capillaries - physiology</topic><topic>Ear - blood supply</topic><topic>Hyperemia - etiology</topic><topic>Hyperemia - physiopathology</topic><topic>Ischemia - complications</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Hairless - growth & development</topic><topic>Mice, Hairless - physiology</topic><topic>Microcirculation - physiology</topic><topic>Oxygen - blood</topic><topic>Skin - blood supply</topic><topic>Venules - growth & development</topic><topic>Venules - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vollmar, Brigitte</creatorcontrib><creatorcontrib>Morgenthaler, Martin</creatorcontrib><creatorcontrib>Amon, Michaela</creatorcontrib><creatorcontrib>Menger, Michael D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vollmar, Brigitte</au><au>Morgenthaler, Martin</au><au>Amon, Michaela</au><au>Menger, Michael D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skin microvascular adaptations during maturation and aging of hairless mice</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>279</volume><issue>4</issue><spage>H1591</spage><epage>H1599</epage><pages>H1591-H1599</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><abstract>Institute for Clinical and Experimental Surgery, University of
Saarland, D-66421 Homburg/Saar, Germany
Using intravital fluorescence microscopy in the ears of
hairless mice, we determined skin microvascular adaptations during the
process of aging from juvenile to adult and senescent life (6-78
wk). Despite an increase of ear area within the first 36 wk,
the number and branching pattern of both arteriolar and venular microvessels remained constant during the whole life period. Both arterioles and venules exhibited an increase in length, diameter, and
intervascular distance up to the age of 36 wk. With the increase of the
size of the ears, the observation that cutaneous capillary density
remained unchanged implied new capillary formation. During aging to 78 wk, capillary density in the ears was reduced to ~40%. Functional
analysis revealed an appropriate hyperemic response to a 2-min period
of ischemia during late juvenile and adult life, which, however, was
markedly reduced during senescence. Thus, except for capillaries, there
is no indication for age-related new vessel formation. The process of
aging from adult to senescent life does not cause any significant
remodeling but is associated with a decrease of nutritive perfusion and
a functional impairment to respond to stimuli such as ischemia.
growth; tortuosity; elongation; intervascular distance; capillary
density</abstract><cop>United States</cop><pmid>11009445</pmid><doi>10.1152/ajpheart.2000.279.4.h1591</doi></addata></record> |
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| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 2000-10, Vol.279 (4), p.H1591-H1599 |
| issn | 0363-6135 1522-1539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72298745 |
| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals |
| subjects | Adaptation, Physiological Aging - physiology Animals Arterioles - growth & development Arterioles - physiology Capillaries - physiology Ear - blood supply Hyperemia - etiology Hyperemia - physiopathology Ischemia - complications Male Mice Mice, Hairless - growth & development Mice, Hairless - physiology Microcirculation - physiology Oxygen - blood Skin - blood supply Venules - growth & development Venules - physiology |
| title | Skin microvascular adaptations during maturation and aging of hairless mice |
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