Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins
We present here a series of high-density maps of single-nucleotide polymorphisms (SNPs) detected in genes encoding three organic-anion transporters, three organic anion-transporting polypeptides, and three nicotinamide adenine dinucleotide, reduced:ubiquinone oxidoreductase flavoproteins. A total of...
Gespeichert in:
| Veröffentlicht in: | Journal of human genetics 2001-01, Vol.46 (11), p.668-683 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 683 |
|---|---|
| container_issue | 11 |
| container_start_page | 668 |
| container_title | Journal of human genetics |
| container_volume | 46 |
| creator | Iida, A. Saito, S. Sekine, A. Mishima, C. Kondo, K. Kitamura, Y. Harigae, S. Osawa, S. Nakamura, Y. |
| description | We present here a series of high-density maps of single-nucleotide polymorphisms (SNPs) detected in genes encoding three organic-anion transporters, three organic anion-transporting polypeptides, and three nicotinamide adenine dinucleotide, reduced:ubiquinone oxidoreductase flavoproteins. A total of 258 SNPs were identified among these nine genes through systematic screening of DNA from 48 Japanese individuals: 17 in 5′ flanking regions, three in 5′ untranslated regions, 13 in coding regions, 211 in introns, six in 3′ untranslated regions, and 8 in 3′ flanking regions. By comparing our data with SNPs deposited in the dbSNP database in the National Center for Biotechnology Information, we determined that 236 (91.5%) were novel. In addition, 46 genetic variations of other types were discovered within these loci. These high-resolution maps will serve as a useful resource for analyzing potential associations between variations in these nine genes and differences in human susceptibilities to common diseases or response to drug therapies. |
| doi_str_mv | 10.1007/s100380170019 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72298012</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2425615049</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-11d77fe3a9d3708b11727660a59b4c947d7a8c61885c7f972238e056710300923</originalsourceid><addsrcrecordid>eNptkV9r1jAUxoMobk4vvZWAIAp2JmnTtLsbr38mjCmo4F3Jm5x2GW3S5aTiPqVfydT3xaHs5iSQ3_M84TyEPOXsmDOm3mCeZcO4Yoy398ghr0pZiFJ8v__nXhWS1_yAPEK8YpkUSjwkB5wrwZtGHZJfG530GAYaeipkQ9H5YYTCL2aEkJwFOofxZgpxvnQ4IX355eIzvqLO0wE8IAVvgs0ami4jAA1x0N4ZmkfwNEXtcQ4xQcTXdxHFX2K1WJNmmNfUjGtv95KL07dnJ8vWXS_OB58tfjobItjFJI1A-1H_CHMMCZzHx-RBr0eEJ_vziHx7_-7r5qw4__Th4-b0vDCSs1RwbpXqodStLRVrtutCVF0zLdttZdpKWaUbU-cdSaP6VglRNsBkrTgrGWtFeURe7Hxz8PUCmLrJoYFx1B7Cgl1WtLmVFXz-H3gVlujz3zpRCVlzyao2U8WOMjEgRui7ObpJx5uOs27tufun58w_27su2wnsLb0vNgPHOwDzkx8g3sbe7fgbdHi0Og</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2425615049</pqid></control><display><type>article</type><title>Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Iida, A. ; Saito, S. ; Sekine, A. ; Mishima, C. ; Kondo, K. ; Kitamura, Y. ; Harigae, S. ; Osawa, S. ; Nakamura, Y.</creator><creatorcontrib>Iida, A. ; Saito, S. ; Sekine, A. ; Mishima, C. ; Kondo, K. ; Kitamura, Y. ; Harigae, S. ; Osawa, S. ; Nakamura, Y.</creatorcontrib><description>We present here a series of high-density maps of single-nucleotide polymorphisms (SNPs) detected in genes encoding three organic-anion transporters, three organic anion-transporting polypeptides, and three nicotinamide adenine dinucleotide, reduced:ubiquinone oxidoreductase flavoproteins. A total of 258 SNPs were identified among these nine genes through systematic screening of DNA from 48 Japanese individuals: 17 in 5′ flanking regions, three in 5′ untranslated regions, 13 in coding regions, 211 in introns, six in 3′ untranslated regions, and 8 in 3′ flanking regions. By comparing our data with SNPs deposited in the dbSNP database in the National Center for Biotechnology Information, we determined that 236 (91.5%) were novel. In addition, 46 genetic variations of other types were discovered within these loci. These high-resolution maps will serve as a useful resource for analyzing potential associations between variations in these nine genes and differences in human susceptibilities to common diseases or response to drug therapies.</description><identifier>ISSN: 1434-5161</identifier><identifier>EISSN: 1435-232X</identifier><identifier>DOI: 10.1007/s100380170019</identifier><identifier>PMID: 11721887</identifier><language>eng</language><publisher>Tokyo: Springer-Verlag</publisher><subject>3' Untranslated regions ; 5' Untranslated Regions ; Adenine ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Chromosome Mapping ; DNA - blood ; DNA - isolation & purification ; Drug therapy ; Electron Transport Complex I ; European Continental Ancestry Group - genetics ; Exons ; Flavoproteins ; Flavoproteins - genetics ; Gene Expression ; Gene Function ; Gene mapping ; Gene Therapy ; Genetic diversity ; Human Genetics ; Humans ; Introns ; Ions ; Japan ; Molecular Medicine ; Multigene Family ; NAD ; NADH ; NADH, NADPH Oxidoreductases - genetics ; NADH-ubiquinone oxidoreductase ; Organic Anion Transporters - genetics ; Organic Anion Transporters, Sodium-Independent ; Original Article ; Polymorphism, Single Nucleotide - genetics ; Polypeptides ; Single-nucleotide polymorphism ; Solute Carrier Organic Anion Transporter Family Member 1b1 - genetics ; Ubiquinone ; Ubiquinone oxidoreductase</subject><ispartof>Journal of human genetics, 2001-01, Vol.46 (11), p.668-683</ispartof><rights>The Japanese Society of Human Genetics and Springer-Verlag Tokyo 2001</rights><rights>The Japanese Society of Human Genetics and Springer-Verlag Tokyo 2001.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-11d77fe3a9d3708b11727660a59b4c947d7a8c61885c7f972238e056710300923</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s100380170019$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s100380170019$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11721887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iida, A.</creatorcontrib><creatorcontrib>Saito, S.</creatorcontrib><creatorcontrib>Sekine, A.</creatorcontrib><creatorcontrib>Mishima, C.</creatorcontrib><creatorcontrib>Kondo, K.</creatorcontrib><creatorcontrib>Kitamura, Y.</creatorcontrib><creatorcontrib>Harigae, S.</creatorcontrib><creatorcontrib>Osawa, S.</creatorcontrib><creatorcontrib>Nakamura, Y.</creatorcontrib><title>Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins</title><title>Journal of human genetics</title><addtitle>J Hum Genet</addtitle><addtitle>J Hum Genet</addtitle><description>We present here a series of high-density maps of single-nucleotide polymorphisms (SNPs) detected in genes encoding three organic-anion transporters, three organic anion-transporting polypeptides, and three nicotinamide adenine dinucleotide, reduced:ubiquinone oxidoreductase flavoproteins. A total of 258 SNPs were identified among these nine genes through systematic screening of DNA from 48 Japanese individuals: 17 in 5′ flanking regions, three in 5′ untranslated regions, 13 in coding regions, 211 in introns, six in 3′ untranslated regions, and 8 in 3′ flanking regions. By comparing our data with SNPs deposited in the dbSNP database in the National Center for Biotechnology Information, we determined that 236 (91.5%) were novel. In addition, 46 genetic variations of other types were discovered within these loci. These high-resolution maps will serve as a useful resource for analyzing potential associations between variations in these nine genes and differences in human susceptibilities to common diseases or response to drug therapies.</description><subject>3' Untranslated regions</subject><subject>5' Untranslated Regions</subject><subject>Adenine</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Chromosome Mapping</subject><subject>DNA - blood</subject><subject>DNA - isolation & purification</subject><subject>Drug therapy</subject><subject>Electron Transport Complex I</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Exons</subject><subject>Flavoproteins</subject><subject>Flavoproteins - genetics</subject><subject>Gene Expression</subject><subject>Gene Function</subject><subject>Gene mapping</subject><subject>Gene Therapy</subject><subject>Genetic diversity</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Introns</subject><subject>Ions</subject><subject>Japan</subject><subject>Molecular Medicine</subject><subject>Multigene Family</subject><subject>NAD</subject><subject>NADH</subject><subject>NADH, NADPH Oxidoreductases - genetics</subject><subject>NADH-ubiquinone oxidoreductase</subject><subject>Organic Anion Transporters - genetics</subject><subject>Organic Anion Transporters, Sodium-Independent</subject><subject>Original Article</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Polypeptides</subject><subject>Single-nucleotide polymorphism</subject><subject>Solute Carrier Organic Anion Transporter Family Member 1b1 - genetics</subject><subject>Ubiquinone</subject><subject>Ubiquinone oxidoreductase</subject><issn>1434-5161</issn><issn>1435-232X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkV9r1jAUxoMobk4vvZWAIAp2JmnTtLsbr38mjCmo4F3Jm5x2GW3S5aTiPqVfydT3xaHs5iSQ3_M84TyEPOXsmDOm3mCeZcO4Yoy398ghr0pZiFJ8v__nXhWS1_yAPEK8YpkUSjwkB5wrwZtGHZJfG530GAYaeipkQ9H5YYTCL2aEkJwFOofxZgpxvnQ4IX355eIzvqLO0wE8IAVvgs0ami4jAA1x0N4ZmkfwNEXtcQ4xQcTXdxHFX2K1WJNmmNfUjGtv95KL07dnJ8vWXS_OB58tfjobItjFJI1A-1H_CHMMCZzHx-RBr0eEJ_vziHx7_-7r5qw4__Th4-b0vDCSs1RwbpXqodStLRVrtutCVF0zLdttZdpKWaUbU-cdSaP6VglRNsBkrTgrGWtFeURe7Hxz8PUCmLrJoYFx1B7Cgl1WtLmVFXz-H3gVlujz3zpRCVlzyao2U8WOMjEgRui7ObpJx5uOs27tufun58w_27su2wnsLb0vNgPHOwDzkx8g3sbe7fgbdHi0Og</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Iida, A.</creator><creator>Saito, S.</creator><creator>Sekine, A.</creator><creator>Mishima, C.</creator><creator>Kondo, K.</creator><creator>Kitamura, Y.</creator><creator>Harigae, S.</creator><creator>Osawa, S.</creator><creator>Nakamura, Y.</creator><general>Springer-Verlag</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20010101</creationdate><title>Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins</title><author>Iida, A. ; Saito, S. ; Sekine, A. ; Mishima, C. ; Kondo, K. ; Kitamura, Y. ; Harigae, S. ; Osawa, S. ; Nakamura, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-11d77fe3a9d3708b11727660a59b4c947d7a8c61885c7f972238e056710300923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>3' Untranslated regions</topic><topic>5' Untranslated Regions</topic><topic>Adenine</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Chromosome Mapping</topic><topic>DNA - blood</topic><topic>DNA - isolation & purification</topic><topic>Drug therapy</topic><topic>Electron Transport Complex I</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Exons</topic><topic>Flavoproteins</topic><topic>Flavoproteins - genetics</topic><topic>Gene Expression</topic><topic>Gene Function</topic><topic>Gene mapping</topic><topic>Gene Therapy</topic><topic>Genetic diversity</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Introns</topic><topic>Ions</topic><topic>Japan</topic><topic>Molecular Medicine</topic><topic>Multigene Family</topic><topic>NAD</topic><topic>NADH</topic><topic>NADH, NADPH Oxidoreductases - genetics</topic><topic>NADH-ubiquinone oxidoreductase</topic><topic>Organic Anion Transporters - genetics</topic><topic>Organic Anion Transporters, Sodium-Independent</topic><topic>Original Article</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Polypeptides</topic><topic>Single-nucleotide polymorphism</topic><topic>Solute Carrier Organic Anion Transporter Family Member 1b1 - genetics</topic><topic>Ubiquinone</topic><topic>Ubiquinone oxidoreductase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iida, A.</creatorcontrib><creatorcontrib>Saito, S.</creatorcontrib><creatorcontrib>Sekine, A.</creatorcontrib><creatorcontrib>Mishima, C.</creatorcontrib><creatorcontrib>Kondo, K.</creatorcontrib><creatorcontrib>Kitamura, Y.</creatorcontrib><creatorcontrib>Harigae, S.</creatorcontrib><creatorcontrib>Osawa, S.</creatorcontrib><creatorcontrib>Nakamura, Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iida, A.</au><au>Saito, S.</au><au>Sekine, A.</au><au>Mishima, C.</au><au>Kondo, K.</au><au>Kitamura, Y.</au><au>Harigae, S.</au><au>Osawa, S.</au><au>Nakamura, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins</atitle><jtitle>Journal of human genetics</jtitle><stitle>J Hum Genet</stitle><addtitle>J Hum Genet</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>46</volume><issue>11</issue><spage>668</spage><epage>683</epage><pages>668-683</pages><issn>1434-5161</issn><eissn>1435-232X</eissn><abstract>We present here a series of high-density maps of single-nucleotide polymorphisms (SNPs) detected in genes encoding three organic-anion transporters, three organic anion-transporting polypeptides, and three nicotinamide adenine dinucleotide, reduced:ubiquinone oxidoreductase flavoproteins. A total of 258 SNPs were identified among these nine genes through systematic screening of DNA from 48 Japanese individuals: 17 in 5′ flanking regions, three in 5′ untranslated regions, 13 in coding regions, 211 in introns, six in 3′ untranslated regions, and 8 in 3′ flanking regions. By comparing our data with SNPs deposited in the dbSNP database in the National Center for Biotechnology Information, we determined that 236 (91.5%) were novel. In addition, 46 genetic variations of other types were discovered within these loci. These high-resolution maps will serve as a useful resource for analyzing potential associations between variations in these nine genes and differences in human susceptibilities to common diseases or response to drug therapies.</abstract><cop>Tokyo</cop><pub>Springer-Verlag</pub><pmid>11721887</pmid><doi>10.1007/s100380170019</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1434-5161 |
| ispartof | Journal of human genetics, 2001-01, Vol.46 (11), p.668-683 |
| issn | 1434-5161 1435-232X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72298012 |
| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 3' Untranslated regions 5' Untranslated Regions Adenine Biomedical and Life Sciences Biomedicine Biotechnology Chromosome Mapping DNA - blood DNA - isolation & purification Drug therapy Electron Transport Complex I European Continental Ancestry Group - genetics Exons Flavoproteins Flavoproteins - genetics Gene Expression Gene Function Gene mapping Gene Therapy Genetic diversity Human Genetics Humans Introns Ions Japan Molecular Medicine Multigene Family NAD NADH NADH, NADPH Oxidoreductases - genetics NADH-ubiquinone oxidoreductase Organic Anion Transporters - genetics Organic Anion Transporters, Sodium-Independent Original Article Polymorphism, Single Nucleotide - genetics Polypeptides Single-nucleotide polymorphism Solute Carrier Organic Anion Transporter Family Member 1b1 - genetics Ubiquinone Ubiquinone oxidoreductase |
| title | Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T04%3A04%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Catalog%20of%20258%20single-nucleotide%20polymorphisms%20(SNPs)%20in%20genes%20encoding%20three%20organic%20anion%20transporters,%20three%20organic%20anion-transporting%20polypeptides,%20and%20three%20NADH:ubiquinone%20oxidoreductase%20flavoproteins&rft.jtitle=Journal%20of%20human%20genetics&rft.au=Iida,%20A.&rft.date=2001-01-01&rft.volume=46&rft.issue=11&rft.spage=668&rft.epage=683&rft.pages=668-683&rft.issn=1434-5161&rft.eissn=1435-232X&rft_id=info:doi/10.1007/s100380170019&rft_dat=%3Cproquest_cross%3E2425615049%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2425615049&rft_id=info:pmid/11721887&rfr_iscdi=true |