Inflammatory response and angiogenesis after percutaneous transmyocardial laser revascularization
Background. The aim of our study was to investigate the inflammatory response immediately after percutaneous transmyocardial laser revascularization (PTMR) along with the underlying mechanism of angiogenesis. Methods. Patients with angina pectoris underwent coronary angiography and were divided into...
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| Veröffentlicht in: | The Annals of thoracic surgery 2000-09, Vol.70 (3), p.1134-1138 |
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| creator | Bortone, Alessandro S D’Agostino, Donato Schena, Stefano Rubini, Giuseppe Brindicci, Paolino Sardaro, Vito D’Addabbo, Angelo de Luca Tupputi Schinosa, Luigi |
| description | Background. The aim of our study was to investigate the inflammatory response immediately after percutaneous transmyocardial laser revascularization (PTMR) along with the underlying mechanism of angiogenesis.
Methods. Patients with angina pectoris underwent coronary angiography and were divided into two groups. Group A (n = 10) included patients with obstructed vessels who received PTMR, whereas group B (n = 5) comprised patients who had normal coronary arteries. Blood levels of neutrophils, procalcitonin, troponin-I, myoglobin, and creatine kinase (CK) mass were evaluated in each patient before angiography and monitored up to 48 hours after the procedure. Six patients were injected with
99mTc-leukoscan approximately 60 to 90 minutes after PTMR. During the 240 to 300 minutes after the radionuclide administration, single photon emission tomography (SPET) was performed and compared with conventional
99mTc-sestamibi-SPET.
Results. A significant increase in blood levels of neutrophils and procalcitonin was observed in group A only (
p < 0.005). A slight but significant increase of troponin-I was evident in the same group (
p < 0.05), and a distinct myocardial uptake of
99mTc-Leukoscan-SPET was observed in each patient along homologous regions treated by PTMR.
Conclusions. The increased amount of neutrophils (both circulating and inside the treated myocardial areas) along with the raised levels of procalcitonin were the immediate reactions to PTMR. This systemic and intramyocardial inflammatory response is the underlying mechanism that gives rise to angiogenesis. |
| doi_str_mv | 10.1016/S0003-4975(00)01745-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72297807</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0003497500017458</els_id><sourcerecordid>72297807</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-71fbcc30921a47f01706d57a52ce992da1a6c3d69074a25d3aa0a5ada19e2d4a3</originalsourceid><addsrcrecordid>eNqFkEtr3DAQgEVIabZpf0KCD6G0Bzcj2bJWp1BCH4FAD03PYiKNg4ptbTR2YPvrq80uzbGHQYz0zUOfEGcSPkmQ3eVPAGjq1hr9AeAjSNPqen0kVlJrVXdK22Ox-oeciDfMv0uqyvNrcSJ3LRrbrQTeTP2A44hzytsqE2_SxFThFEo8xPRAE3HkCvuZcrWh7JcZJ0oLV3PGicdt8phDxKEakAuS6QnZLwPm-AfnmKa34lWPA9O7w3kqfn39cnf9vb798e3m-vNt7VvVzbWR_b33DVglsTV9-RB0QRvUypO1KqDEzjehs2BaVDo0iIAay70lFVpsTsX7fd9NTo8L8ezGyJ6GYb-uM0pZswZTQL0HfU7MmXq3yXHEvHUS3E6Me3brduIcgHt269al7vwwYLkfKbxUHWQW4OIAFAM49MWPj_zCabkGawt2tceo2HiKlB37SJOnEDP52YUU_7PJX3mQmHk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72297807</pqid></control><display><type>article</type><title>Inflammatory response and angiogenesis after percutaneous transmyocardial laser revascularization</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Bortone, Alessandro S ; D’Agostino, Donato ; Schena, Stefano ; Rubini, Giuseppe ; Brindicci, Paolino ; Sardaro, Vito ; D’Addabbo, Angelo ; de Luca Tupputi Schinosa, Luigi</creator><creatorcontrib>Bortone, Alessandro S ; D’Agostino, Donato ; Schena, Stefano ; Rubini, Giuseppe ; Brindicci, Paolino ; Sardaro, Vito ; D’Addabbo, Angelo ; de Luca Tupputi Schinosa, Luigi</creatorcontrib><description>Background. The aim of our study was to investigate the inflammatory response immediately after percutaneous transmyocardial laser revascularization (PTMR) along with the underlying mechanism of angiogenesis.
Methods. Patients with angina pectoris underwent coronary angiography and were divided into two groups. Group A (n = 10) included patients with obstructed vessels who received PTMR, whereas group B (n = 5) comprised patients who had normal coronary arteries. Blood levels of neutrophils, procalcitonin, troponin-I, myoglobin, and creatine kinase (CK) mass were evaluated in each patient before angiography and monitored up to 48 hours after the procedure. Six patients were injected with
99mTc-leukoscan approximately 60 to 90 minutes after PTMR. During the 240 to 300 minutes after the radionuclide administration, single photon emission tomography (SPET) was performed and compared with conventional
99mTc-sestamibi-SPET.
Results. A significant increase in blood levels of neutrophils and procalcitonin was observed in group A only (
p < 0.005). A slight but significant increase of troponin-I was evident in the same group (
p < 0.05), and a distinct myocardial uptake of
99mTc-Leukoscan-SPET was observed in each patient along homologous regions treated by PTMR.
Conclusions. The increased amount of neutrophils (both circulating and inside the treated myocardial areas) along with the raised levels of procalcitonin were the immediate reactions to PTMR. This systemic and intramyocardial inflammatory response is the underlying mechanism that gives rise to angiogenesis.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/S0003-4975(00)01745-8</identifier><identifier>PMID: 11016396</identifier><identifier>CODEN: ATHSAK</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Antibodies, Monoclonal ; Antibodies, Monoclonal, Murine-Derived ; Biological and medical sciences ; Calcitonin - blood ; Calcitonin Gene-Related Peptide ; Diseases of the cardiovascular system ; Female ; Humans ; Inflammation - etiology ; Laser Therapy ; Leukocyte Count ; Male ; Medical sciences ; Middle Aged ; Minimally Invasive Surgical Procedures ; Myocardial Revascularization ; Neovascularization, Physiologic - physiology ; Neutrophils ; Protein Precursors - blood ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Technetium ; Tomography, Emission-Computed, Single-Photon ; Troponin I - blood</subject><ispartof>The Annals of thoracic surgery, 2000-09, Vol.70 (3), p.1134-1138</ispartof><rights>2000 The Society of Thoracic Surgeons</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-71fbcc30921a47f01706d57a52ce992da1a6c3d69074a25d3aa0a5ada19e2d4a3</citedby><cites>FETCH-LOGICAL-c426t-71fbcc30921a47f01706d57a52ce992da1a6c3d69074a25d3aa0a5ada19e2d4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0003497500017458$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1518099$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11016396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bortone, Alessandro S</creatorcontrib><creatorcontrib>D’Agostino, Donato</creatorcontrib><creatorcontrib>Schena, Stefano</creatorcontrib><creatorcontrib>Rubini, Giuseppe</creatorcontrib><creatorcontrib>Brindicci, Paolino</creatorcontrib><creatorcontrib>Sardaro, Vito</creatorcontrib><creatorcontrib>D’Addabbo, Angelo</creatorcontrib><creatorcontrib>de Luca Tupputi Schinosa, Luigi</creatorcontrib><title>Inflammatory response and angiogenesis after percutaneous transmyocardial laser revascularization</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Background. The aim of our study was to investigate the inflammatory response immediately after percutaneous transmyocardial laser revascularization (PTMR) along with the underlying mechanism of angiogenesis.
Methods. Patients with angina pectoris underwent coronary angiography and were divided into two groups. Group A (n = 10) included patients with obstructed vessels who received PTMR, whereas group B (n = 5) comprised patients who had normal coronary arteries. Blood levels of neutrophils, procalcitonin, troponin-I, myoglobin, and creatine kinase (CK) mass were evaluated in each patient before angiography and monitored up to 48 hours after the procedure. Six patients were injected with
99mTc-leukoscan approximately 60 to 90 minutes after PTMR. During the 240 to 300 minutes after the radionuclide administration, single photon emission tomography (SPET) was performed and compared with conventional
99mTc-sestamibi-SPET.
Results. A significant increase in blood levels of neutrophils and procalcitonin was observed in group A only (
p < 0.005). A slight but significant increase of troponin-I was evident in the same group (
p < 0.05), and a distinct myocardial uptake of
99mTc-Leukoscan-SPET was observed in each patient along homologous regions treated by PTMR.
Conclusions. The increased amount of neutrophils (both circulating and inside the treated myocardial areas) along with the raised levels of procalcitonin were the immediate reactions to PTMR. This systemic and intramyocardial inflammatory response is the underlying mechanism that gives rise to angiogenesis.</description><subject>Antibodies, Monoclonal</subject><subject>Antibodies, Monoclonal, Murine-Derived</subject><subject>Biological and medical sciences</subject><subject>Calcitonin - blood</subject><subject>Calcitonin Gene-Related Peptide</subject><subject>Diseases of the cardiovascular system</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - etiology</subject><subject>Laser Therapy</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Minimally Invasive Surgical Procedures</subject><subject>Myocardial Revascularization</subject><subject>Neovascularization, Physiologic - physiology</subject><subject>Neutrophils</subject><subject>Protein Precursors - blood</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Technetium</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Troponin I - blood</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtr3DAQgEVIabZpf0KCD6G0Bzcj2bJWp1BCH4FAD03PYiKNg4ptbTR2YPvrq80uzbGHQYz0zUOfEGcSPkmQ3eVPAGjq1hr9AeAjSNPqen0kVlJrVXdK22Ox-oeciDfMv0uqyvNrcSJ3LRrbrQTeTP2A44hzytsqE2_SxFThFEo8xPRAE3HkCvuZcrWh7JcZJ0oLV3PGicdt8phDxKEakAuS6QnZLwPm-AfnmKa34lWPA9O7w3kqfn39cnf9vb798e3m-vNt7VvVzbWR_b33DVglsTV9-RB0QRvUypO1KqDEzjehs2BaVDo0iIAay70lFVpsTsX7fd9NTo8L8ezGyJ6GYb-uM0pZswZTQL0HfU7MmXq3yXHEvHUS3E6Me3brduIcgHt269al7vwwYLkfKbxUHWQW4OIAFAM49MWPj_zCabkGawt2tceo2HiKlB37SJOnEDP52YUU_7PJX3mQmHk</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Bortone, Alessandro S</creator><creator>D’Agostino, Donato</creator><creator>Schena, Stefano</creator><creator>Rubini, Giuseppe</creator><creator>Brindicci, Paolino</creator><creator>Sardaro, Vito</creator><creator>D’Addabbo, Angelo</creator><creator>de Luca Tupputi Schinosa, Luigi</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000901</creationdate><title>Inflammatory response and angiogenesis after percutaneous transmyocardial laser revascularization</title><author>Bortone, Alessandro S ; D’Agostino, Donato ; Schena, Stefano ; Rubini, Giuseppe ; Brindicci, Paolino ; Sardaro, Vito ; D’Addabbo, Angelo ; de Luca Tupputi Schinosa, Luigi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-71fbcc30921a47f01706d57a52ce992da1a6c3d69074a25d3aa0a5ada19e2d4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antibodies, Monoclonal</topic><topic>Antibodies, Monoclonal, Murine-Derived</topic><topic>Biological and medical sciences</topic><topic>Calcitonin - blood</topic><topic>Calcitonin Gene-Related Peptide</topic><topic>Diseases of the cardiovascular system</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation - etiology</topic><topic>Laser Therapy</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Minimally Invasive Surgical Procedures</topic><topic>Myocardial Revascularization</topic><topic>Neovascularization, Physiologic - physiology</topic><topic>Neutrophils</topic><topic>Protein Precursors - blood</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Technetium</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Troponin I - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bortone, Alessandro S</creatorcontrib><creatorcontrib>D’Agostino, Donato</creatorcontrib><creatorcontrib>Schena, Stefano</creatorcontrib><creatorcontrib>Rubini, Giuseppe</creatorcontrib><creatorcontrib>Brindicci, Paolino</creatorcontrib><creatorcontrib>Sardaro, Vito</creatorcontrib><creatorcontrib>D’Addabbo, Angelo</creatorcontrib><creatorcontrib>de Luca Tupputi Schinosa, Luigi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bortone, Alessandro S</au><au>D’Agostino, Donato</au><au>Schena, Stefano</au><au>Rubini, Giuseppe</au><au>Brindicci, Paolino</au><au>Sardaro, Vito</au><au>D’Addabbo, Angelo</au><au>de Luca Tupputi Schinosa, Luigi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammatory response and angiogenesis after percutaneous transmyocardial laser revascularization</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>70</volume><issue>3</issue><spage>1134</spage><epage>1138</epage><pages>1134-1138</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><coden>ATHSAK</coden><abstract>Background. The aim of our study was to investigate the inflammatory response immediately after percutaneous transmyocardial laser revascularization (PTMR) along with the underlying mechanism of angiogenesis.
Methods. Patients with angina pectoris underwent coronary angiography and were divided into two groups. Group A (n = 10) included patients with obstructed vessels who received PTMR, whereas group B (n = 5) comprised patients who had normal coronary arteries. Blood levels of neutrophils, procalcitonin, troponin-I, myoglobin, and creatine kinase (CK) mass were evaluated in each patient before angiography and monitored up to 48 hours after the procedure. Six patients were injected with
99mTc-leukoscan approximately 60 to 90 minutes after PTMR. During the 240 to 300 minutes after the radionuclide administration, single photon emission tomography (SPET) was performed and compared with conventional
99mTc-sestamibi-SPET.
Results. A significant increase in blood levels of neutrophils and procalcitonin was observed in group A only (
p < 0.005). A slight but significant increase of troponin-I was evident in the same group (
p < 0.05), and a distinct myocardial uptake of
99mTc-Leukoscan-SPET was observed in each patient along homologous regions treated by PTMR.
Conclusions. The increased amount of neutrophils (both circulating and inside the treated myocardial areas) along with the raised levels of procalcitonin were the immediate reactions to PTMR. This systemic and intramyocardial inflammatory response is the underlying mechanism that gives rise to angiogenesis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11016396</pmid><doi>10.1016/S0003-4975(00)01745-8</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Antibodies, Monoclonal Antibodies, Monoclonal, Murine-Derived Biological and medical sciences Calcitonin - blood Calcitonin Gene-Related Peptide Diseases of the cardiovascular system Female Humans Inflammation - etiology Laser Therapy Leukocyte Count Male Medical sciences Middle Aged Minimally Invasive Surgical Procedures Myocardial Revascularization Neovascularization, Physiologic - physiology Neutrophils Protein Precursors - blood Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Technetium Tomography, Emission-Computed, Single-Photon Troponin I - blood |
| title | Inflammatory response and angiogenesis after percutaneous transmyocardial laser revascularization |
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