Serum Selenium and Subsequent Risk of Prostate Cancer
It is suspected that selenium is protective against prostate cancer. To test this hypothesis, we conducted a nested case-control study in a cohort of 9345 Japanese-American men examined between 1971 and 1977. At the time of examination, a blood specimen was obtained, and the serum was frozen. After...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2000-09, Vol.9 (9), p.883-887 |
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| creator | NOMURA, Abraham M. Y LEE, James STEMMERMANN, Grant N COMBS, Gerald F |
| description | It is suspected that selenium is protective against prostate cancer. To
test this hypothesis, we conducted a nested case-control study in a
cohort of 9345 Japanese-American men examined between 1971 and
1977. At the time of examination, a blood specimen was obtained,
and the serum was frozen. After a surveillance period of more than 20
years, 249 tissue-confirmed incident cases of prostate cancer were
identified. Their stored sera and those of 249 matched controls were
measured for selenium levels. Odds ratios for prostate cancer, based on
quartiles of serum selenium levels, were determined using the General
Estimating Equations approach. The multivariate odds ratio for the
highest quartile was 0.5 (95% confidence interval, 0.3–0.9) with a
two-sided P for trend of 0.02. The inverse association
was more notable for cases with advanced disease and for cases
diagnosed 5–15 years after phlebotomy. However, the association was
mainly present in current or past cigarette smokers rather than
nonsmokers, which leads to caution in the interpretation of the
results. |
| format | Article |
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test this hypothesis, we conducted a nested case-control study in a
cohort of 9345 Japanese-American men examined between 1971 and
1977. At the time of examination, a blood specimen was obtained,
and the serum was frozen. After a surveillance period of more than 20
years, 249 tissue-confirmed incident cases of prostate cancer were
identified. Their stored sera and those of 249 matched controls were
measured for selenium levels. Odds ratios for prostate cancer, based on
quartiles of serum selenium levels, were determined using the General
Estimating Equations approach. The multivariate odds ratio for the
highest quartile was 0.5 (95% confidence interval, 0.3–0.9) with a
two-sided P for trend of 0.02. The inverse association
was more notable for cases with advanced disease and for cases
diagnosed 5–15 years after phlebotomy. However, the association was
mainly present in current or past cigarette smokers rather than
nonsmokers, which leads to caution in the interpretation of the
results.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>PMID: 11008904</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Aged ; Analysis. Health state ; Biological and medical sciences ; Case-Control Studies ; Epidemiology ; General aspects ; Hawaii - epidemiology ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Odds Ratio ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - epidemiology ; Prostatic Neoplasms - etiology ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Selenium - blood ; Smoking - adverse effects ; Smoking - blood ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2000-09, Vol.9 (9), p.883-887</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1506056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11008904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NOMURA, Abraham M. Y</creatorcontrib><creatorcontrib>LEE, James</creatorcontrib><creatorcontrib>STEMMERMANN, Grant N</creatorcontrib><creatorcontrib>COMBS, Gerald F</creatorcontrib><title>Serum Selenium and Subsequent Risk of Prostate Cancer</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>It is suspected that selenium is protective against prostate cancer. To
test this hypothesis, we conducted a nested case-control study in a
cohort of 9345 Japanese-American men examined between 1971 and
1977. At the time of examination, a blood specimen was obtained,
and the serum was frozen. After a surveillance period of more than 20
years, 249 tissue-confirmed incident cases of prostate cancer were
identified. Their stored sera and those of 249 matched controls were
measured for selenium levels. Odds ratios for prostate cancer, based on
quartiles of serum selenium levels, were determined using the General
Estimating Equations approach. The multivariate odds ratio for the
highest quartile was 0.5 (95% confidence interval, 0.3–0.9) with a
two-sided P for trend of 0.02. The inverse association
was more notable for cases with advanced disease and for cases
diagnosed 5–15 years after phlebotomy. However, the association was
mainly present in current or past cigarette smokers rather than
nonsmokers, which leads to caution in the interpretation of the
results.</description><subject>Aged</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Epidemiology</subject><subject>General aspects</subject><subject>Hawaii - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Odds Ratio</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Prostatic Neoplasms - etiology</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Selenium - blood</subject><subject>Smoking - adverse effects</subject><subject>Smoking - blood</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj01LxDAQhoMo7rr6F6QH8VZImk6SHqWoKyworp5Lkk5ttB9r0iL-e4OuLHOY9_Aw8z5HZMmAq1RKgOOYKUBaFAIW5CyEd0qpLABOyYIxSlVB8yWBLfq5T7bY4eBi0EOdbGcT8HPGYUqeXfhIxiZ58mOY9IRJqQeL_pycNLoLeLHfK_J6d_tSrtPN4_1DebNJ20zIKdWG59YK5EwoK_LM1IobxWK73EgOppFGypwiCqyZagxYLiRyCdxYpmXOV-T67-7Oj7FQmKreBYtdpwcc51DJLCtk1Irg5R6cTY91tfOu1_67-heNwNUe0MHqrvHRw4UDB1RQEIeHrXtrv5zHyv4KewyovW2rIo5SnP8A7j1o_Q</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>NOMURA, Abraham M. Y</creator><creator>LEE, James</creator><creator>STEMMERMANN, Grant N</creator><creator>COMBS, Gerald F</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20000901</creationdate><title>Serum Selenium and Subsequent Risk of Prostate Cancer</title><author>NOMURA, Abraham M. Y ; LEE, James ; STEMMERMANN, Grant N ; COMBS, Gerald F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h267t-ab34cc6e3168c642bd83b817754b735bf7b7740ee6ed18fb5c367e3753bc1a743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Analysis. Health state</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Epidemiology</topic><topic>General aspects</topic><topic>Hawaii - epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Odds Ratio</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Prostatic Neoplasms - etiology</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Selenium - blood</topic><topic>Smoking - adverse effects</topic><topic>Smoking - blood</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NOMURA, Abraham M. Y</creatorcontrib><creatorcontrib>LEE, James</creatorcontrib><creatorcontrib>STEMMERMANN, Grant N</creatorcontrib><creatorcontrib>COMBS, Gerald F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NOMURA, Abraham M. Y</au><au>LEE, James</au><au>STEMMERMANN, Grant N</au><au>COMBS, Gerald F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Selenium and Subsequent Risk of Prostate Cancer</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>9</volume><issue>9</issue><spage>883</spage><epage>887</epage><pages>883-887</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>It is suspected that selenium is protective against prostate cancer. To
test this hypothesis, we conducted a nested case-control study in a
cohort of 9345 Japanese-American men examined between 1971 and
1977. At the time of examination, a blood specimen was obtained,
and the serum was frozen. After a surveillance period of more than 20
years, 249 tissue-confirmed incident cases of prostate cancer were
identified. Their stored sera and those of 249 matched controls were
measured for selenium levels. Odds ratios for prostate cancer, based on
quartiles of serum selenium levels, were determined using the General
Estimating Equations approach. The multivariate odds ratio for the
highest quartile was 0.5 (95% confidence interval, 0.3–0.9) with a
two-sided P for trend of 0.02. The inverse association
was more notable for cases with advanced disease and for cases
diagnosed 5–15 years after phlebotomy. However, the association was
mainly present in current or past cigarette smokers rather than
nonsmokers, which leads to caution in the interpretation of the
results.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>11008904</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2000-09, Vol.9 (9), p.883-887 |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Analysis. Health state Biological and medical sciences Case-Control Studies Epidemiology General aspects Hawaii - epidemiology Humans Incidence Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Odds Ratio Prostatic Neoplasms - blood Prostatic Neoplasms - epidemiology Prostatic Neoplasms - etiology Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Selenium - blood Smoking - adverse effects Smoking - blood Tumors of the urinary system Urinary tract. Prostate gland |
| title | Serum Selenium and Subsequent Risk of Prostate Cancer |
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