Computer-aided design, synthesis and biological assay of p-methylsulfonamido phenylethylamine analogues

Class III antiarrhythmic agents selectively delay the effective refractory period (ERP) and increase the transmembrance action potential duration (APD). Based on our previous studies, a set of 17 methylsulfonamido phenylethylamine analogues were investigated by 3D-QSAR techniques of CoMFA and CoMSIA...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-10, Vol.10 (19), p.2153-2157
Hauptverfasser:	Liu, Hong, Ji, Min, Jiang, Hualiang, Liu, Ligang, Hua, Weiyi, Chen, Kaixian, Ji, Ruyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Arrhythmia Agents - chemical synthesis Anti-Arrhythmia Agents - chemistry Anti-Arrhythmia Agents - pharmacology Antiarythmic agents Biological and medical sciences Cardiovascular system Computer Simulation Drug Design Heart Atria - drug effects In Vitro Techniques Medical sciences Molecular Structure Pharmacology. Drug treatments Phenethylamines - chemical synthesis Phenethylamines - chemistry Phenethylamines - pharmacology Potassium Channel Blockers Potassium Channels - metabolism Quantitative Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology
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