The Impact of H2-DM on Humoral Immune Responses

H2-DM (DM, previously H2-M) facilitates the exchange of peptides bound to MHC class II molecules. In this study, we have used H2-DM-deficient (DM(-/-)) mice to analyze the influence of DM in the priming of B cell responses in vivo and for Ag presentation by B cells in vitro. After immunization, IgG...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-12, Vol.167 (11), p.6348-6355
Hauptverfasser:	Alfonso, Christopher, Han, Jung-Ok, Williams, G. Stuart, Karlsson, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Affinity - genetics Antibody Formation - genetics Antigen Presentation - genetics B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism Germinal Center - immunology Germinal Center - pathology H-2 Antigens - biosynthesis H-2 Antigens - genetics Haptens - administration & dosage Haptens - immunology Hemocyanins - administration & dosage Hemocyanins - immunology histocompatibility antigen H-2 Histocompatibility Antigens Class II - biosynthesis Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - physiology HLA-D Antigens - genetics HLA-D Antigens - physiology Hybridomas Immunoglobulin G - biosynthesis Injections, Intraperitoneal Mice Mice, Knockout Mice, Transgenic Muramidase - administration & dosage Muramidase - immunology Nitrophenols - administration & dosage Nitrophenols - immunology Ovalbumin - administration & dosage Ovalbumin - immunology Peptide Fragments - genetics Peptide Fragments - immunology Peptide Fragments - metabolism Phenylacetates Receptors, Fc - physiology T-Lymphocytes - immunology Transgenes - immunology
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