Dilated Cardiomyopathy and Sudden Death Resulting From Constitutive Activation of Protein Kinase A

β-Adrenergic receptor (βAR) signaling, which elevates intracellular cAMP and enhances cardiac contractility, is severely impaired in the failing heart. Protein kinase A (PKA) is activated by cAMP, but the long-term physiological effect of PKA activation on cardiac function is unclear. To investigate...

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Veröffentlicht in:	Circulation research 2001-11, Vol.89 (11), p.997-1004
Hauptverfasser:	Antos, Christopher L, Frey, Norbert, Marx, Steven O, Reiken, Steven, Gaburjakova, Marta, Richardson, James A, Marks, Andrew R, Olson, Eric N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Binding Proteins - metabolism Cardiomyopathy, Dilated - enzymology Cardiomyopathy, Dilated - etiology Cardiomyopathy, Dilated - metabolism Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Cyclic AMP-Dependent Protein Kinases - physiology Death, Sudden, Cardiac - etiology Enzyme Activation Humans Mice Mice, Transgenic Myocardial Contraction Myosin Heavy Chains - genetics Phosphorylation Ryanodine Receptor Calcium Release Channel - metabolism
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