Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome

Fragile X syndrome results from the absence of the RNA binding FMR protein. Here, mRNA was coimmunoprecipitated with the FMRP ribonucleoprotein complex and used to interrogate microarrays. We identified 432 associated mRNAs from mouse brain. Quantitative RT-PCR confirmed some to be >60-fold enric...

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Veröffentlicht in:	Cell 2001-11, Vol.107 (4), p.477-487
Hauptverfasser:	Brown, Victoria, Jin, Peng, Ceman, Stephanie, Darnell, Jennifer C., O'Donnell, William T., Tenenbaum, Scott A., Jin, Xiaokui, Feng, Yue, Wilkinson, Keith D., Keene, Jack D., Darnell, Robert B., Warren, Stephen T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Brain Chemistry Centrifugation, Density Gradient Disease Models, Animal FMR protein FMRP protein Fragile X Mental Retardation Protein fragile X syndrome Fragile X Syndrome - genetics Humans Ligands Macromolecular Substances Mice Mice, Inbred C57BL Mice, Knockout microarrays Models, Genetic Molecular Sequence Data Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Precipitin Tests Protein Binding Protein Biosynthesis Regulatory Sequences, Nucleic Acid Ribosomes - metabolism RNA, Messenger - chemistry RNA, Messenger - isolation & purification RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - physiology Sequence Alignment Sequence Homology, Amino Acid
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