Identification of DNA amplifications near the center of the Streptomyces coelicolor M145 chromosome
Abstract Linear streptomycete chromosomes frequently undergo spontaneous gross DNA rearrangements at the terminal regions. Large DNA deletions of the chromosome ends are in many cases associated with tandemly reiterated DNA amplifications, found at the border of the deletable areas. In contrast to p...
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| Veröffentlicht in: | FEMS microbiology letters 2000-10, Vol.191 (1), p.123-129 |
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| container_title | FEMS microbiology letters |
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| creator | Redenbach, Matthias Kleinert, Eveline Stoll, Alexander |
| description | Abstract
Linear streptomycete chromosomes frequently undergo spontaneous gross DNA rearrangements at the terminal regions. Large DNA deletions of the chromosome ends are in many cases associated with tandemly reiterated DNA amplifications, found at the border of the deletable areas. In contrast to previous reports, we have discovered amplifications near the center of the Streptomyces coelicolor M145 chromosome. The detected amplified units of DNA are 19.9 kb and 16 kb in length and exist in copy numbers of 30 and 40, respectively. Both amplifications were located in the same region and share at least 3.6 kb. |
| doi_str_mv | 10.1111/j.1574-6968.2000.tb09328.x |
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Linear streptomycete chromosomes frequently undergo spontaneous gross DNA rearrangements at the terminal regions. Large DNA deletions of the chromosome ends are in many cases associated with tandemly reiterated DNA amplifications, found at the border of the deletable areas. In contrast to previous reports, we have discovered amplifications near the center of the Streptomyces coelicolor M145 chromosome. The detected amplified units of DNA are 19.9 kb and 16 kb in length and exist in copy numbers of 30 and 40, respectively. Both amplifications were located in the same region and share at least 3.6 kb.</description><identifier>ISSN: 0378-1097</identifier><identifier>EISSN: 1574-6968</identifier><identifier>DOI: 10.1111/j.1574-6968.2000.tb09328.x</identifier><identifier>PMID: 11004409</identifier><identifier>CODEN: FMLED7</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amplification ; Bacteriology ; Biological and medical sciences ; Chromosomes ; Chromosomes, Bacterial - genetics ; Cosmids - genetics ; Deoxyribonucleases, Type II Site-Specific - metabolism ; Deoxyribonucleic acid ; DNA ; DNA amplification ; DNA Transposable Elements ; Electrophoresis, Polyacrylamide Gel ; Fundamental and applied biological sciences. Psychology ; Gene Amplification ; Genetics ; Genome structure ; Microbiology ; Mutation ; Restriction Mapping ; Streptomyces ; Streptomyces - genetics ; Streptomyces coelicolor</subject><ispartof>FEMS microbiology letters, 2000-10, Vol.191 (1), p.123-129</ispartof><rights>2000 Federation of European Microbiological Societies 2000</rights><rights>2001 INIST-CNRS</rights><rights>2000 Federation of European Microbiological Societies</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4043-2372a2d2bd1f8ff5a787aaf0642f3fa695881ff903e8e962a87987010863d7453</citedby><cites>FETCH-LOGICAL-c4043-2372a2d2bd1f8ff5a787aaf0642f3fa695881ff903e8e962a87987010863d7453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1574-6968.2000.tb09328.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1574-6968.2000.tb09328.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=960525$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11004409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Redenbach, Matthias</creatorcontrib><creatorcontrib>Kleinert, Eveline</creatorcontrib><creatorcontrib>Stoll, Alexander</creatorcontrib><title>Identification of DNA amplifications near the center of the Streptomyces coelicolor M145 chromosome</title><title>FEMS microbiology letters</title><addtitle>FEMS Microbiol Lett</addtitle><description>Abstract
Linear streptomycete chromosomes frequently undergo spontaneous gross DNA rearrangements at the terminal regions. Large DNA deletions of the chromosome ends are in many cases associated with tandemly reiterated DNA amplifications, found at the border of the deletable areas. In contrast to previous reports, we have discovered amplifications near the center of the Streptomyces coelicolor M145 chromosome. The detected amplified units of DNA are 19.9 kb and 16 kb in length and exist in copy numbers of 30 and 40, respectively. Both amplifications were located in the same region and share at least 3.6 kb.</description><subject>Amplification</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Chromosomes</subject><subject>Chromosomes, Bacterial - genetics</subject><subject>Cosmids - genetics</subject><subject>Deoxyribonucleases, Type II Site-Specific - metabolism</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA amplification</subject><subject>DNA Transposable Elements</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Amplification</subject><subject>Genetics</subject><subject>Genome structure</subject><subject>Microbiology</subject><subject>Mutation</subject><subject>Restriction Mapping</subject><subject>Streptomyces</subject><subject>Streptomyces - genetics</subject><subject>Streptomyces coelicolor</subject><issn>0378-1097</issn><issn>1574-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqVkUtv1DAUhS1ERaeFv4AskNglvbYTP1ggVaWFSlNYAGvL49hqRkkc7ER0_j2OZjQgRBf1xq_vHh-fi9AbAiXJ42JbklpUBVdclhQAymkDilFZPjxDq-PVc7QCJmRBQIlTdJbSNqMVBf4CnRKSlxWoFbK3jRum1rfWTG0YcPD445dLbPqxOx4mPDgT8XTvsM2wiwu17L5N0Y1T6HfWJWyD61obuhDxHalqbO9j6EMKvXuJTrzpknt1mM_Rj5vr71efi_XXT7dXl-vCVlCxgjJBDW3opiFeel8bIYUxHnhFPfOGq1pK4r0C5qRTnBoplBRAQHLWiKpm5-jdXneM4efs0qT7NlnXdWZwYU5aUKqIZJDBt_-A2zDHIXvTlOVseFYmmXq_p2wMKUXn9Rjb3sSdJqCXRuitXtLWS9p6aYQ-NEI_5OLXhyfmTe-aP6WH5P_yYJI1nY9msG06copDTZcvfdhTv9rO7Z5gQN_crQllWaDeC4R5fKS8-J__397Vs2Q</recordid><startdate>200010</startdate><enddate>200010</enddate><creator>Redenbach, Matthias</creator><creator>Kleinert, Eveline</creator><creator>Stoll, Alexander</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200010</creationdate><title>Identification of DNA amplifications near the center of the Streptomyces coelicolor M145 chromosome</title><author>Redenbach, Matthias ; Kleinert, Eveline ; Stoll, Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4043-2372a2d2bd1f8ff5a787aaf0642f3fa695881ff903e8e962a87987010863d7453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Amplification</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Chromosomes</topic><topic>Chromosomes, Bacterial - genetics</topic><topic>Cosmids - genetics</topic><topic>Deoxyribonucleases, Type II Site-Specific - metabolism</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA amplification</topic><topic>DNA Transposable Elements</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Amplification</topic><topic>Genetics</topic><topic>Genome structure</topic><topic>Microbiology</topic><topic>Mutation</topic><topic>Restriction Mapping</topic><topic>Streptomyces</topic><topic>Streptomyces - genetics</topic><topic>Streptomyces coelicolor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Redenbach, Matthias</creatorcontrib><creatorcontrib>Kleinert, Eveline</creatorcontrib><creatorcontrib>Stoll, Alexander</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEMS microbiology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Redenbach, Matthias</au><au>Kleinert, Eveline</au><au>Stoll, Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of DNA amplifications near the center of the Streptomyces coelicolor M145 chromosome</atitle><jtitle>FEMS microbiology letters</jtitle><addtitle>FEMS Microbiol Lett</addtitle><date>2000-10</date><risdate>2000</risdate><volume>191</volume><issue>1</issue><spage>123</spage><epage>129</epage><pages>123-129</pages><issn>0378-1097</issn><eissn>1574-6968</eissn><coden>FMLED7</coden><abstract>Abstract
Linear streptomycete chromosomes frequently undergo spontaneous gross DNA rearrangements at the terminal regions. Large DNA deletions of the chromosome ends are in many cases associated with tandemly reiterated DNA amplifications, found at the border of the deletable areas. In contrast to previous reports, we have discovered amplifications near the center of the Streptomyces coelicolor M145 chromosome. The detected amplified units of DNA are 19.9 kb and 16 kb in length and exist in copy numbers of 30 and 40, respectively. Both amplifications were located in the same region and share at least 3.6 kb.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>11004409</pmid><doi>10.1111/j.1574-6968.2000.tb09328.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | FEMS microbiology letters, 2000-10, Vol.191 (1), p.123-129 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Amplification Bacteriology Biological and medical sciences Chromosomes Chromosomes, Bacterial - genetics Cosmids - genetics Deoxyribonucleases, Type II Site-Specific - metabolism Deoxyribonucleic acid DNA DNA amplification DNA Transposable Elements Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology Gene Amplification Genetics Genome structure Microbiology Mutation Restriction Mapping Streptomyces Streptomyces - genetics Streptomyces coelicolor |
| title | Identification of DNA amplifications near the center of the Streptomyces coelicolor M145 chromosome |
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