alpha-Latrotoxin, acting via two Ca2+-dependent pathways, triggers exocytosis of two pools of synaptic vesicles

alpha-Latrotoxin stimulates three types of [(3)H]gamma-aminobutyric acid and [(14)C]glutamate release from synaptosomes. The Ca(2+)-independent component (i) is insensitive to SNAP-25 cleavage or depletion of vesicle contents by bafilomycin A1 and represents transmitter efflux mediated by alpha-latr...

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Veröffentlicht in:	The Journal of biological chemistry 2001-11, Vol.276 (48), p.44695-44703
Hauptverfasser:	Ashton, A C, Volynski, K E, Lelianova, V G, Orlova, E V, Van Renterghem, C, Canepari, M, Seagar, M, Ushkaryov, Y A
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 4-Kinase - metabolism Amino Acids - metabolism Animals Calcium - metabolism Cells, Cultured Cytosol - metabolism Electrophysiology Enzyme Activation Exocytosis Hippocampus - metabolism Microscopy, Electron Mutation Neurons - metabolism Protein Binding Rats Recombinant Proteins - metabolism Spider Venoms - chemistry Spider Venoms - metabolism Spiders Sucrose - metabolism Synapses - metabolism Synaptosomes - metabolism Time Factors
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