Vitamin C induced apoptosis in human articular chondrocytes
Chondrocytes present in articular cartilage survive as a resident cell population throughout the lifespan of the individual organism. However, articular chondrocytes as other cells also undergo apoptosis and there is an ever increasing list of diverse stimuli that can induce this phenomenon in vitro...
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| Veröffentlicht in: | Pflügers Archiv 2000, Vol.440 (5 Suppl), p.R46-R048 |
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| container_end_page | R048 |
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| container_issue | 5 Suppl |
| container_start_page | R46 |
| container_title | Pflügers Archiv |
| container_volume | 440 |
| creator | Malicev, E Woyniak, G Knezevic, M Radosavljević, D Jeras, M |
| description | Chondrocytes present in articular cartilage survive as a resident cell population throughout the lifespan of the individual organism. However, articular chondrocytes as other cells also undergo apoptosis and there is an ever increasing list of diverse stimuli that can induce this phenomenon in vitro. Our main interest was to investigate potential cytotoxic effects of vitamin C (L-ascorbic acid) on human articular chondrocytes. The present study suggests that vitamin C can induce apoptosis in a cell culture of chondrocytes after 18 h of cultivation. Apoptosis-inducing activity of L-ascorbic acid is dose dependent and significantly affected by the presence of serum. The increased number of vitamin C induced apoptotic cells was associated with DNA fragmentation and morphological changes of the cells. |
| doi_str_mv | 10.1007/s004240000001 |
| format | Article |
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| subjects | Apoptosis Ascorbic Acid - pharmacology Cartilage, Articular - cytology Cartilage, Articular - drug effects Cells, Cultured Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - physiology DNA Fragmentation Dose-Response Relationship, Drug Humans Time Factors |
| title | Vitamin C induced apoptosis in human articular chondrocytes |
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