Quality of life changes during conformal radiation therapy for prostate carcinoma
BACKGROUND The objective of this study was to describe prospectively quality of life (QOL) before and after radiotherapy for patients with prostate carcinoma. METHODS Forty‐three patients with T1–T3 prostate carcinoma who underwent conformal external beam radiation therapy were randomized either to...
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| Veröffentlicht in: | Cancer 2000-09, Vol.89 (6), p.1322-1328 |
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| creator | Janda, Monika Gerstner, Natascha Obermair, Andreas Fuerst, Annerose Wachter, Stefan Dieckmann, Karin Pötter, Richard |
| description | BACKGROUND
The objective of this study was to describe prospectively quality of life (QOL) before and after radiotherapy for patients with prostate carcinoma.
METHODS
Forty‐three patients with T1–T3 prostate carcinoma who underwent conformal external beam radiation therapy were randomized either to the complete European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaire (EORTC QLQ‐C30) or the Medical Outcomes Study Group Short Form Health Survey (SF‐36) at baseline, at 3 weeks and 6 weeks after initial treatment, and at 6 weeks and 5 months after the completion of radiotherapy. The measures were self‐reported patient QOL, and values are given as the mean ± standard error of the mean. Changes in QOL are described from baseline to the end of treatment in both questionnaire groups.
RESULTS
Emotional role functioning, as measured with the SF‐36 questionnaire, significantly improved from 68.2 ± 9.9 at baseline to 93.3 ± 5.2 at the end of therapy (P = 0.02). The EORTC QLQ‐C30 questionnaire revealed consistent values of emotional functioning during treatment (72.7 ± 5.9 at baseline) but showed a significant improvement 6 weeks after therapy (89.0 ± 4.4; P = 0.01). Role functioning deteriorated from 80.1 ± 6.5 at baseline to 62.5 ± 8.8 at the end of radiotherapy (P = 0.02). Symptoms of fatigue were shown to increase significantly from 26.9 ± 6.0 at baseline to 37.7 ± 7.6 at the end of therapy (P = 0.02). No significant changes in the other dimensions were observed in either questionnaire.
CONCLUSIONS
After radiotherapy for prostate carcinoma, patients experience a temporary deterioration of fatigue and role functioning, as measured with the EORTC QLQ‐C‐30. Despite physical deterioration, the authors observed an improvement in emotional functioning scores with both questionnaires. This may have been due to psychological adaptation and coping. Cancer 2000;89:1322–8. © 2000 American Cancer Society.
In patients with prostate carcinoma who were undergoing conformal external beam radiation therapy, fatigue and role functioning deteriorated temporarily during radiotherapy. Emotional functioning scales showed an improvement during the observation period. |
| doi_str_mv | 10.1002/1097-0142(20000915)89:6<1322::AID-CNCR18>3.0.CO;2-D |
| format | Article |
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The objective of this study was to describe prospectively quality of life (QOL) before and after radiotherapy for patients with prostate carcinoma.
METHODS
Forty‐three patients with T1–T3 prostate carcinoma who underwent conformal external beam radiation therapy were randomized either to the complete European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaire (EORTC QLQ‐C30) or the Medical Outcomes Study Group Short Form Health Survey (SF‐36) at baseline, at 3 weeks and 6 weeks after initial treatment, and at 6 weeks and 5 months after the completion of radiotherapy. The measures were self‐reported patient QOL, and values are given as the mean ± standard error of the mean. Changes in QOL are described from baseline to the end of treatment in both questionnaire groups.
RESULTS
Emotional role functioning, as measured with the SF‐36 questionnaire, significantly improved from 68.2 ± 9.9 at baseline to 93.3 ± 5.2 at the end of therapy (P = 0.02). The EORTC QLQ‐C30 questionnaire revealed consistent values of emotional functioning during treatment (72.7 ± 5.9 at baseline) but showed a significant improvement 6 weeks after therapy (89.0 ± 4.4; P = 0.01). Role functioning deteriorated from 80.1 ± 6.5 at baseline to 62.5 ± 8.8 at the end of radiotherapy (P = 0.02). Symptoms of fatigue were shown to increase significantly from 26.9 ± 6.0 at baseline to 37.7 ± 7.6 at the end of therapy (P = 0.02). No significant changes in the other dimensions were observed in either questionnaire.
CONCLUSIONS
After radiotherapy for prostate carcinoma, patients experience a temporary deterioration of fatigue and role functioning, as measured with the EORTC QLQ‐C‐30. Despite physical deterioration, the authors observed an improvement in emotional functioning scores with both questionnaires. This may have been due to psychological adaptation and coping. Cancer 2000;89:1322–8. © 2000 American Cancer Society.
In patients with prostate carcinoma who were undergoing conformal external beam radiation therapy, fatigue and role functioning deteriorated temporarily during radiotherapy. Emotional functioning scales showed an improvement during the observation period.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(20000915)89:6<1322::AID-CNCR18>3.0.CO;2-D</identifier><identifier>PMID: 11002229</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Combined Modality Therapy ; emotional functioning ; fatigue ; Genital system. Mammary gland ; Humans ; Male ; Medical sciences ; Middle Aged ; Prospective Studies ; Prostate ; prostate carcinoma ; Prostatic Neoplasms - radiotherapy ; Prostatic Neoplasms - surgery ; Quality of Life ; radiotherapy ; Radiotherapy, Conformal ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; role functioning ; Surveys and Questionnaires</subject><ispartof>Cancer, 2000-09, Vol.89 (6), p.1322-1328</ispartof><rights>Copyright © 2000 American Cancer Society</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4678-e7802127d9df1e7e97347dbf9d11c9f137437e3b60cbf3a10590ba094dd2e5f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1097-0142%2820000915%2989%3A6%3C1322%3A%3AAID-CNCR18%3E3.0.CO%3B2-D$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1097-0142%2820000915%2989%3A6%3C1322%3A%3AAID-CNCR18%3E3.0.CO%3B2-D$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1505056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11002229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janda, Monika</creatorcontrib><creatorcontrib>Gerstner, Natascha</creatorcontrib><creatorcontrib>Obermair, Andreas</creatorcontrib><creatorcontrib>Fuerst, Annerose</creatorcontrib><creatorcontrib>Wachter, Stefan</creatorcontrib><creatorcontrib>Dieckmann, Karin</creatorcontrib><creatorcontrib>Pötter, Richard</creatorcontrib><title>Quality of life changes during conformal radiation therapy for prostate carcinoma</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
The objective of this study was to describe prospectively quality of life (QOL) before and after radiotherapy for patients with prostate carcinoma.
METHODS
Forty‐three patients with T1–T3 prostate carcinoma who underwent conformal external beam radiation therapy were randomized either to the complete European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaire (EORTC QLQ‐C30) or the Medical Outcomes Study Group Short Form Health Survey (SF‐36) at baseline, at 3 weeks and 6 weeks after initial treatment, and at 6 weeks and 5 months after the completion of radiotherapy. The measures were self‐reported patient QOL, and values are given as the mean ± standard error of the mean. Changes in QOL are described from baseline to the end of treatment in both questionnaire groups.
RESULTS
Emotional role functioning, as measured with the SF‐36 questionnaire, significantly improved from 68.2 ± 9.9 at baseline to 93.3 ± 5.2 at the end of therapy (P = 0.02). The EORTC QLQ‐C30 questionnaire revealed consistent values of emotional functioning during treatment (72.7 ± 5.9 at baseline) but showed a significant improvement 6 weeks after therapy (89.0 ± 4.4; P = 0.01). Role functioning deteriorated from 80.1 ± 6.5 at baseline to 62.5 ± 8.8 at the end of radiotherapy (P = 0.02). Symptoms of fatigue were shown to increase significantly from 26.9 ± 6.0 at baseline to 37.7 ± 7.6 at the end of therapy (P = 0.02). No significant changes in the other dimensions were observed in either questionnaire.
CONCLUSIONS
After radiotherapy for prostate carcinoma, patients experience a temporary deterioration of fatigue and role functioning, as measured with the EORTC QLQ‐C‐30. Despite physical deterioration, the authors observed an improvement in emotional functioning scores with both questionnaires. This may have been due to psychological adaptation and coping. Cancer 2000;89:1322–8. © 2000 American Cancer Society.
In patients with prostate carcinoma who were undergoing conformal external beam radiation therapy, fatigue and role functioning deteriorated temporarily during radiotherapy. Emotional functioning scales showed an improvement during the observation period.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Combined Modality Therapy</subject><subject>emotional functioning</subject><subject>fatigue</subject><subject>Genital system. Mammary gland</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Prostate</subject><subject>prostate carcinoma</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Quality of Life</subject><subject>radiotherapy</subject><subject>Radiotherapy, Conformal</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>role functioning</subject><subject>Surveys and Questionnaires</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkEtv1DAUhS0EotPCX0BeIEQXGfxI4niKkKoMj0oVo_ISuyvHj9Yoj8FOhObf42gC3bDBXljXPufe4w-hC0rWlBD2ihIpMkJz9pKRtCQtziu5KV9Tzthmc3m1zeqP9SdaveFrsq53FyzbPkCrv66HaJVcVVbk_PsJOo3xRyoFK_hjdELnAYzJFbq5mVTrxwMeHG69s1jfqf7WRmym4PtbrIfeDaFTLQ7KeDX6ocfjnQ1qf8DpAe_DEEc1Jp8K2vdDp56gR0610T5dzjP09d3bL_WH7Hr3_qq-vM50Xooqs6IijDJhpHHUCisFz4VpnDSUaukoFzkXljcl0Y3jipJCkkYRmRvDbOEYP0Mvjn1ThJ-TjSN0Pmrbtqq3wxRBpP-RsiiT8PNRqFPWGKyDffCdCgegBGYQMDODmRn8IQ2VhBJm0gCJNBxJAwcC9Q4YbFPXZ8v4qemsue-5oE2C54tARa1aF1SvfbzXFSTtOd23o-yXb-3h_6L9M9lyw38DdSWkRQ</recordid><startdate>20000915</startdate><enddate>20000915</enddate><creator>Janda, Monika</creator><creator>Gerstner, Natascha</creator><creator>Obermair, Andreas</creator><creator>Fuerst, Annerose</creator><creator>Wachter, Stefan</creator><creator>Dieckmann, Karin</creator><creator>Pötter, Richard</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000915</creationdate><title>Quality of life changes during conformal radiation therapy for prostate carcinoma</title><author>Janda, Monika ; Gerstner, Natascha ; Obermair, Andreas ; Fuerst, Annerose ; Wachter, Stefan ; Dieckmann, Karin ; Pötter, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4678-e7802127d9df1e7e97347dbf9d11c9f137437e3b60cbf3a10590ba094dd2e5f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Combined Modality Therapy</topic><topic>emotional functioning</topic><topic>fatigue</topic><topic>Genital system. Mammary gland</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Prostate</topic><topic>prostate carcinoma</topic><topic>Prostatic Neoplasms - radiotherapy</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Quality of Life</topic><topic>radiotherapy</topic><topic>Radiotherapy, Conformal</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>role functioning</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janda, Monika</creatorcontrib><creatorcontrib>Gerstner, Natascha</creatorcontrib><creatorcontrib>Obermair, Andreas</creatorcontrib><creatorcontrib>Fuerst, Annerose</creatorcontrib><creatorcontrib>Wachter, Stefan</creatorcontrib><creatorcontrib>Dieckmann, Karin</creatorcontrib><creatorcontrib>Pötter, Richard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janda, Monika</au><au>Gerstner, Natascha</au><au>Obermair, Andreas</au><au>Fuerst, Annerose</au><au>Wachter, Stefan</au><au>Dieckmann, Karin</au><au>Pötter, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality of life changes during conformal radiation therapy for prostate carcinoma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2000-09-15</date><risdate>2000</risdate><volume>89</volume><issue>6</issue><spage>1322</spage><epage>1328</epage><pages>1322-1328</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
The objective of this study was to describe prospectively quality of life (QOL) before and after radiotherapy for patients with prostate carcinoma.
METHODS
Forty‐three patients with T1–T3 prostate carcinoma who underwent conformal external beam radiation therapy were randomized either to the complete European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaire (EORTC QLQ‐C30) or the Medical Outcomes Study Group Short Form Health Survey (SF‐36) at baseline, at 3 weeks and 6 weeks after initial treatment, and at 6 weeks and 5 months after the completion of radiotherapy. The measures were self‐reported patient QOL, and values are given as the mean ± standard error of the mean. Changes in QOL are described from baseline to the end of treatment in both questionnaire groups.
RESULTS
Emotional role functioning, as measured with the SF‐36 questionnaire, significantly improved from 68.2 ± 9.9 at baseline to 93.3 ± 5.2 at the end of therapy (P = 0.02). The EORTC QLQ‐C30 questionnaire revealed consistent values of emotional functioning during treatment (72.7 ± 5.9 at baseline) but showed a significant improvement 6 weeks after therapy (89.0 ± 4.4; P = 0.01). Role functioning deteriorated from 80.1 ± 6.5 at baseline to 62.5 ± 8.8 at the end of radiotherapy (P = 0.02). Symptoms of fatigue were shown to increase significantly from 26.9 ± 6.0 at baseline to 37.7 ± 7.6 at the end of therapy (P = 0.02). No significant changes in the other dimensions were observed in either questionnaire.
CONCLUSIONS
After radiotherapy for prostate carcinoma, patients experience a temporary deterioration of fatigue and role functioning, as measured with the EORTC QLQ‐C‐30. Despite physical deterioration, the authors observed an improvement in emotional functioning scores with both questionnaires. This may have been due to psychological adaptation and coping. Cancer 2000;89:1322–8. © 2000 American Cancer Society.
In patients with prostate carcinoma who were undergoing conformal external beam radiation therapy, fatigue and role functioning deteriorated temporarily during radiotherapy. Emotional functioning scales showed an improvement during the observation period.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11002229</pmid><doi>10.1002/1097-0142(20000915)89:6<1322::AID-CNCR18>3.0.CO;2-D</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Biological and medical sciences Combined Modality Therapy emotional functioning fatigue Genital system. Mammary gland Humans Male Medical sciences Middle Aged Prospective Studies Prostate prostate carcinoma Prostatic Neoplasms - radiotherapy Prostatic Neoplasms - surgery Quality of Life radiotherapy Radiotherapy, Conformal Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) role functioning Surveys and Questionnaires |
| title | Quality of life changes during conformal radiation therapy for prostate carcinoma |
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