Cytoadherence of Plasmodium falciparum-Infected Erythrocytes Is Mediated by a Redox-Dependent Conformational Fraction of CD36

The adherence of Plasmodium falciparum-infected RBC (IRBC) to postcapillary venular endothelium is an important determinant of the pathogenesis of severe malaria complications. Cytoadherence of IRBC to endothelial cells involves specific receptor/ligand interactions. The glycoprotein CD36 expressed...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-12, Vol.167 (11), p.6510-6517
Hauptverfasser:	Gruarin, Paola, Primo, Luca, Ferrandi, Chiara, Bussolino, Federico, Tandon, Narendra N, Arese, Paolo, Ulliers, Daniela, Alessio, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Amino Acid Sequence Animals Antibodies, Monoclonal - metabolism Antigen-Antibody Reactions CD36 antigen CD36 Antigens - biosynthesis CD36 Antigens - immunology CD36 Antigens - metabolism CD36 Antigens - physiology Cell Adhesion - drug effects Cell Adhesion - immunology Cell Line Chemical Fractionation COS Cells Cysteine - metabolism Dithiothreitol - pharmacology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Epitopes - biosynthesis Epitopes - immunology Epitopes - metabolism Erythrocyte Aggregation - drug effects Erythrocyte Aggregation - immunology Erythrocytes - drug effects Erythrocytes - immunology Erythrocytes - metabolism Erythrocytes - parasitology Humans Molecular Sequence Data Oxidation-Reduction - drug effects Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - immunology Protein Conformation - drug effects Reducing Agents - pharmacology U937 Cells
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