Metabolic information from the human fetal brain obtained with proton magnetic resonance spectroscopy
Objective: To study the feasibility of proton magnetic resonance spectroscopy for the examination of human fetal brain metabolism. Study Design: Proton magnetic resonance spectroscopy was performed from a selected volume of brain tissue of 21 single normal fetuses of 36 to 41 weeks’ gestational age....
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2001-11, Vol.185 (5), p.1011-1015 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Kok, René D. van den Bergh, Adrianus J. Heerschap, Arend Nijland, Roel van den Berg, Paul P. |
| description | Objective: To study the feasibility of proton magnetic resonance spectroscopy for the examination of human fetal brain metabolism. Study Design: Proton magnetic resonance spectroscopy was performed from a selected volume of brain tissue of 21 single normal fetuses of 36 to 41 weeks’ gestational age. Absolute brain metabolite tissue levels were estimated by using the brain water content as an internal reference. Results: Proton magnetic resonance spectra showed resonances for four dominating brain metabolites. Inositol, choline, creatine, and N-acetylaspartate could be detected with average tissue levels of 7.42 mmol/L, 3.31 mmol/L, 4.16 mmol/L, and 5.03 mmol/L, respectively. The resonance for N-acetylaspartate could not always be resolved from contaminating lipid signals. Conclusion: Proton magnetic resonance spectroscopy of the human fetal brain is feasible and can provide useful information about the fetal condition. The metabolite tissue levels for the fetal brain obtained in this study were in the range observed for neonates of similar gestational age. (Am J Obstet Gynecol 2001;185:1011–5.) |
| doi_str_mv | 10.1067/mob.2001.117677 |
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Study Design: Proton magnetic resonance spectroscopy was performed from a selected volume of brain tissue of 21 single normal fetuses of 36 to 41 weeks’ gestational age. Absolute brain metabolite tissue levels were estimated by using the brain water content as an internal reference. Results: Proton magnetic resonance spectra showed resonances for four dominating brain metabolites. Inositol, choline, creatine, and N-acetylaspartate could be detected with average tissue levels of 7.42 mmol/L, 3.31 mmol/L, 4.16 mmol/L, and 5.03 mmol/L, respectively. The resonance for N-acetylaspartate could not always be resolved from contaminating lipid signals. Conclusion: Proton magnetic resonance spectroscopy of the human fetal brain is feasible and can provide useful information about the fetal condition. The metabolite tissue levels for the fetal brain obtained in this study were in the range observed for neonates of similar gestational age. (Am J Obstet Gynecol 2001;185:1011–5.)</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1067/mob.2001.117677</identifier><identifier>PMID: 11717623</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Biological and medical sciences ; Brain - embryology ; Brain - metabolism ; Choline - metabolism ; Creatine - metabolism ; Feasibility Studies ; Fetus - metabolism ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Human fetal brain ; Humans ; Inositol - metabolism ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Spectroscopy ; Management. Prenatal diagnosis ; Medical sciences ; Nervous system ; Pregnancy. Fetus. Placenta ; proton magnetic resonance spectroscopy ; Protons ; Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><ispartof>American journal of obstetrics and gynecology, 2001-11, Vol.185 (5), p.1011-1015</ispartof><rights>2001 Mosby, Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-b5a8fa7c3f21bfc63af0cfab0693d14f788806fab9d61fdba7d8d350298edb7e3</citedby><cites>FETCH-LOGICAL-c305t-b5a8fa7c3f21bfc63af0cfab0693d14f788806fab9d61fdba7d8d350298edb7e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002937801826399$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14108829$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11717623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kok, René D.</creatorcontrib><creatorcontrib>van den Bergh, Adrianus J.</creatorcontrib><creatorcontrib>Heerschap, Arend</creatorcontrib><creatorcontrib>Nijland, Roel</creatorcontrib><creatorcontrib>van den Berg, Paul P.</creatorcontrib><title>Metabolic information from the human fetal brain obtained with proton magnetic resonance spectroscopy</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective: To study the feasibility of proton magnetic resonance spectroscopy for the examination of human fetal brain metabolism. Study Design: Proton magnetic resonance spectroscopy was performed from a selected volume of brain tissue of 21 single normal fetuses of 36 to 41 weeks’ gestational age. Absolute brain metabolite tissue levels were estimated by using the brain water content as an internal reference. Results: Proton magnetic resonance spectra showed resonances for four dominating brain metabolites. Inositol, choline, creatine, and N-acetylaspartate could be detected with average tissue levels of 7.42 mmol/L, 3.31 mmol/L, 4.16 mmol/L, and 5.03 mmol/L, respectively. The resonance for N-acetylaspartate could not always be resolved from contaminating lipid signals. Conclusion: Proton magnetic resonance spectroscopy of the human fetal brain is feasible and can provide useful information about the fetal condition. The metabolite tissue levels for the fetal brain obtained in this study were in the range observed for neonates of similar gestational age. (Am J Obstet Gynecol 2001;185:1011–5.)</description><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - embryology</subject><subject>Brain - metabolism</subject><subject>Choline - metabolism</subject><subject>Creatine - metabolism</subject><subject>Feasibility Studies</subject><subject>Fetus - metabolism</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Human fetal brain</subject><subject>Humans</subject><subject>Inositol - metabolism</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>proton magnetic resonance spectroscopy</subject><subject>Protons</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PGzEQhi3UqgTac2_Il3Lb4I9k7T0i1AISiEt7tvwxJq5218F2qPj3nSiROHEazeiZV68eQr5ztuSsV1dTdkvBGF9yrnqlTsiCs0F1ve71J7JgjIlukEqfkrNa_-5XMYgv5BRp5IVcEHiEZl0ek6dpjrlMtqU801jyRNsG6GY3WVwRGqkrNs00u4YDAv2X2oZuS27IT_Z5hoYhBWqe7eyB1i34VnL1efv2lXyOdqzw7TjPyZ9fP3_f3HUPT7f3N9cPnZds3Tq3tjpa5WUU3EXfSxuZj9axfpCBr6LSWrMeD0PoeQzOqqCDXDMxaAhOgTwnl4dcrPWyg9rMlKqHcbQz5F01Sgit5WqF4NUB9NiwFohmW9Jky5vhzOzNGjRr9mbNwSx-XByjd26C8M4fVSLw4wjY6u0YC1pI9Z1bcaa1GJAbDhygiNcExVSfAI2FVNCYCTl9WOI_hCuXgQ</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Kok, René D.</creator><creator>van den Bergh, Adrianus J.</creator><creator>Heerschap, Arend</creator><creator>Nijland, Roel</creator><creator>van den Berg, Paul P.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Metabolic information from the human fetal brain obtained with proton magnetic resonance spectroscopy</title><author>Kok, René D. ; van den Bergh, Adrianus J. ; Heerschap, Arend ; Nijland, Roel ; van den Berg, Paul P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-b5a8fa7c3f21bfc63af0cfab0693d14f788806fab9d61fdba7d8d350298edb7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - embryology</topic><topic>Brain - metabolism</topic><topic>Choline - metabolism</topic><topic>Creatine - metabolism</topic><topic>Feasibility Studies</topic><topic>Fetus - metabolism</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Human fetal brain</topic><topic>Humans</topic><topic>Inositol - metabolism</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>proton magnetic resonance spectroscopy</topic><topic>Protons</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kok, René D.</creatorcontrib><creatorcontrib>van den Bergh, Adrianus J.</creatorcontrib><creatorcontrib>Heerschap, Arend</creatorcontrib><creatorcontrib>Nijland, Roel</creatorcontrib><creatorcontrib>van den Berg, Paul P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kok, René D.</au><au>van den Bergh, Adrianus J.</au><au>Heerschap, Arend</au><au>Nijland, Roel</au><au>van den Berg, Paul P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic information from the human fetal brain obtained with proton magnetic resonance spectroscopy</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>185</volume><issue>5</issue><spage>1011</spage><epage>1015</epage><pages>1011-1015</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective: To study the feasibility of proton magnetic resonance spectroscopy for the examination of human fetal brain metabolism. Study Design: Proton magnetic resonance spectroscopy was performed from a selected volume of brain tissue of 21 single normal fetuses of 36 to 41 weeks’ gestational age. Absolute brain metabolite tissue levels were estimated by using the brain water content as an internal reference. Results: Proton magnetic resonance spectra showed resonances for four dominating brain metabolites. Inositol, choline, creatine, and N-acetylaspartate could be detected with average tissue levels of 7.42 mmol/L, 3.31 mmol/L, 4.16 mmol/L, and 5.03 mmol/L, respectively. The resonance for N-acetylaspartate could not always be resolved from contaminating lipid signals. Conclusion: Proton magnetic resonance spectroscopy of the human fetal brain is feasible and can provide useful information about the fetal condition. The metabolite tissue levels for the fetal brain obtained in this study were in the range observed for neonates of similar gestational age. (Am J Obstet Gynecol 2001;185:1011–5.)</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>11717623</pmid><doi>10.1067/mob.2001.117677</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 2001-11, Vol.185 (5), p.1011-1015 |
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| subjects | Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biological and medical sciences Brain - embryology Brain - metabolism Choline - metabolism Creatine - metabolism Feasibility Studies Fetus - metabolism Gestational Age Gynecology. Andrology. Obstetrics Human fetal brain Humans Inositol - metabolism Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Spectroscopy Management. Prenatal diagnosis Medical sciences Nervous system Pregnancy. Fetus. Placenta proton magnetic resonance spectroscopy Protons Radiodiagnosis. Nmr imagery. Nmr spectrometry |
| title | Metabolic information from the human fetal brain obtained with proton magnetic resonance spectroscopy |
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