c‐Myc inhibits CD11a and CD11c leukocyte integrin promoters

The c‐Myc transcription factor is an important regulator of cell growth and differentiation, and its gene repression ability seems to play a key role in Myc‐mediated cellular transformation. Since Myc overexpression has been associated with reduced expression of β1 and β2 integrins, we have investig...

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Veröffentlicht in:	European journal of immunology 2000-09, Vol.30 (9), p.2465-2471
Hauptverfasser:	López‐Rodríguez, Cristina, Delgado, M. Dolores, Puig‐Kröger, Amaya, Nueda, Arsenio, Muñoz, Eduardo, León, Javier, Bernabéu, Carmelo, Corbí, Angel L.
Format:	Artikel
Sprache:	eng
Schlagworte:	c-Myc protein CD11c promoter Cell Line c‐Myc Humans Integrin Integrin alphaXbeta2 - genetics integrins Lymphocyte Function-Associated Antigen-1 - genetics Promoter Regions, Genetic Proto-Oncogene Proteins c-myc - physiology Repressor Proteins - physiology Response Elements Transcription
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