Fluorescent Tricyclic Analogues of Acyclovir and Ganciclovir. A Structure−Antiviral Activity Study

Of a series of new guanine base modified tricyclic analogues of acyclovir (ACV, 1) and ganciclovir (GCV, 2), derivatives of the 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purine system, evaluated for activity against herpes simplex virus type 1 and 2, several fluorescent analogues, 6-(4-MeOPh)-TACV (8), 7-M...

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Veröffentlicht in:	Journal of medicinal chemistry 2001-11, Vol.44 (24), p.4284-4287
Hauptverfasser:	Golankiewicz, Bozenna, Ostrowski, Tomasz, Goslinski, Tomasz, Januszczyk, Piotr, Zeidler, Joanna, Baranowski, Daniel, de Clercq, Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - analogs & derivatives Acyclovir - chemical synthesis Acyclovir - chemistry Acyclovir - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Cell Line Cytopathogenic Effect, Viral Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacology Ganciclovir - analogs & derivatives Ganciclovir - chemical synthesis Ganciclovir - chemistry Ganciclovir - pharmacology Herpesvirus 1, Human - drug effects Herpesvirus 2, Human - drug effects Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship
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