Characterisation of isolated α-synuclein filaments from substantia nigra of Parkinson's disease brain

The defining neuropathological deposits of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy are strongly immunoreactive for α-synuclein. We have shown previously that isolated filaments from dementia with Lewy bodies and multiple system atrophy brains are labelled in a...

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Veröffentlicht in:	Neuroscience letters 2000-10, Vol.292 (2), p.128-130
Hauptverfasser:	Crowther, R.Anthony, Daniel, Susan E, Goedert, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	a-Synuclein Aged Aged, 80 and over alpha-Synuclein Antibodies Biological and medical sciences Cytoskeleton - chemistry Cytoskeleton - pathology Cytoskeleton - ultrastructure Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia with Lewy bodies Humans Isolated filaments Lewy bodies Lewy Body Disease - pathology Lewy neurites Medical sciences Microscopy, Electron Multiple system atrophy Multiple System Atrophy - pathology Nerve Tissue Proteins - analysis Nerve Tissue Proteins - immunology Neurology Parkinson Disease - pathology Parkinson's disease Substantia nigra Substantia Nigra - chemistry Substantia Nigra - pathology Synucleins α-Synuclein
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