Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria
In Thailand, approximately 8% of patients treated for vivax malaria are found subsequently to have coinfection with Plasmodium falciparum. A P. falciparum histidine rich protein 2 (PfHRP-2) dipstick test was evaluated as a predictor of mixed infections with subpatent P. falciparum in a prospective s...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2001-11, Vol.65 (5), p.588-592 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | Mayxay, M Pukritrayakamee, S Chotivanich, K Imwong, M Looareesuwan, S White, NJ |
| description | In Thailand, approximately 8% of patients treated for vivax malaria are found subsequently to have coinfection with Plasmodium falciparum. A P. falciparum histidine rich protein 2 (PfHRP-2) dipstick test was evaluated as a predictor of mixed infections with subpatent P. falciparum in a prospective study of 238 patients admitted to the hospital with acute vivax malaria. Of these, 23 (10%) had subsequent development of falciparum malaria without reexposure. Patients with cryptic P. falciparum infection had a significantly lower mean (standard deviation) hematocrit than those with P. vivax alone: 29.6 (7.6%) versus 37.2 (6.4%) (P < 0.0001). Using microscopic appearance of P. falciparum after the start of treatment as the reference standard, the PfHRP-2 test was 74% sensitive and 99% specific in predicting mixed infections with subpatent P. falciparum parasitemia at presentation. The PfHRP-2 dipstick test may be a useful adjunct to microscopy in areas where mixed infections are common. |
| doi_str_mv | 10.4269/ajtmh.2001.65.588 |
| format | Article |
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A P. falciparum histidine rich protein 2 (PfHRP-2) dipstick test was evaluated as a predictor of mixed infections with subpatent P. falciparum in a prospective study of 238 patients admitted to the hospital with acute vivax malaria. Of these, 23 (10%) had subsequent development of falciparum malaria without reexposure. Patients with cryptic P. falciparum infection had a significantly lower mean (standard deviation) hematocrit than those with P. vivax alone: 29.6 (7.6%) versus 37.2 (6.4%) (P < 0.0001). Using microscopic appearance of P. falciparum after the start of treatment as the reference standard, the PfHRP-2 test was 74% sensitive and 99% specific in predicting mixed infections with subpatent P. falciparum parasitemia at presentation. 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A P. falciparum histidine rich protein 2 (PfHRP-2) dipstick test was evaluated as a predictor of mixed infections with subpatent P. falciparum in a prospective study of 238 patients admitted to the hospital with acute vivax malaria. Of these, 23 (10%) had subsequent development of falciparum malaria without reexposure. Patients with cryptic P. falciparum infection had a significantly lower mean (standard deviation) hematocrit than those with P. vivax alone: 29.6 (7.6%) versus 37.2 (6.4%) (P < 0.0001). Using microscopic appearance of P. falciparum after the start of treatment as the reference standard, the PfHRP-2 test was 74% sensitive and 99% specific in predicting mixed infections with subpatent P. falciparum parasitemia at presentation. The PfHRP-2 dipstick test may be a useful adjunct to microscopy in areas where mixed infections are common.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria, Falciparum - diagnosis</subject><subject>Malaria, Vivax - complications</subject><subject>Malaria, Vivax - parasitology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parasitic diseases</subject><subject>PfHRP-2 protein</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium vivax</subject><subject>Polymerase Chain Reaction</subject><subject>Proteins - analysis</subject><subject>Protozoal diseases</subject><subject>Sensitivity and Specificity</subject><subject>Tropical medicine</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtvGzEQhInAQSw7-QFpgmuc7hTuHZ9lYDiJAQN2kdTEiuRZFO4V8uSz_r2pB6DSFYnFN7PYGUK-Al2ySugfuJm69bKiFJaCL7lSH8gCmBQlCMYvyIJSWpVa1PKSXKW0yZyqAD6RSwAJAkAvyObe-X4KTbA4haEvhqawcTdOwRZ2CH3j7WE8h2ldPLWYusGFbVc02NowYszf0Bdj1maXVIzRp71d_3xUvIQXfC06bDEG_Ew-ZlnyX07vNfn36-7v7Z_y4fH3_e3Ph9KyGqZSSQroKm1FrbVsvFNMOqiZQ1lVmlFbC865kHrVOFezlRMyjySupOLOOqyvyfej7xiH_1ufJtOFZH3bYu-HbTLZRgml2btgTovXSooMwhG0cUgp-saMMXQYdwao2TdhDk2YfRNGcJObyJpvJ_PtqvPurDhFn4GbE4DJYttE7G1IZ45BvlbxM7cOz-s5RG9SDrTNtmDmed6vOyx8Ay7moXM</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Mayxay, M</creator><creator>Pukritrayakamee, S</creator><creator>Chotivanich, K</creator><creator>Imwong, M</creator><creator>Looareesuwan, S</creator><creator>White, NJ</creator><general>ASTMH</general><general>Allen Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria</title><author>Mayxay, M ; Pukritrayakamee, S ; Chotivanich, K ; Imwong, M ; Looareesuwan, S ; White, NJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-8701ad29c63997fed847d134da722940c36555679bfdd34bd67c367ab785dcda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria, Falciparum - diagnosis</topic><topic>Malaria, Vivax - complications</topic><topic>Malaria, Vivax - parasitology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parasitic diseases</topic><topic>PfHRP-2 protein</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium vivax</topic><topic>Polymerase Chain Reaction</topic><topic>Proteins - analysis</topic><topic>Protozoal diseases</topic><topic>Sensitivity and Specificity</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mayxay, M</creatorcontrib><creatorcontrib>Pukritrayakamee, S</creatorcontrib><creatorcontrib>Chotivanich, K</creatorcontrib><creatorcontrib>Imwong, M</creatorcontrib><creatorcontrib>Looareesuwan, S</creatorcontrib><creatorcontrib>White, NJ</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mayxay, M</au><au>Pukritrayakamee, S</au><au>Chotivanich, K</au><au>Imwong, M</au><au>Looareesuwan, S</au><au>White, NJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>65</volume><issue>5</issue><spage>588</spage><epage>592</epage><pages>588-592</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>In Thailand, approximately 8% of patients treated for vivax malaria are found subsequently to have coinfection with Plasmodium falciparum. A P. falciparum histidine rich protein 2 (PfHRP-2) dipstick test was evaluated as a predictor of mixed infections with subpatent P. falciparum in a prospective study of 238 patients admitted to the hospital with acute vivax malaria. Of these, 23 (10%) had subsequent development of falciparum malaria without reexposure. Patients with cryptic P. falciparum infection had a significantly lower mean (standard deviation) hematocrit than those with P. vivax alone: 29.6 (7.6%) versus 37.2 (6.4%) (P < 0.0001). Using microscopic appearance of P. falciparum after the start of treatment as the reference standard, the PfHRP-2 test was 74% sensitive and 99% specific in predicting mixed infections with subpatent P. falciparum parasitemia at presentation. 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| ispartof | The American journal of tropical medicine and hygiene, 2001-11, Vol.65 (5), p.588-592 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Female Human protozoal diseases Humans Infectious diseases Malaria Malaria, Falciparum - diagnosis Malaria, Vivax - complications Malaria, Vivax - parasitology Male Medical sciences Parasitic diseases PfHRP-2 protein Plasmodium falciparum Plasmodium vivax Polymerase Chain Reaction Proteins - analysis Protozoal diseases Sensitivity and Specificity Tropical medicine |
| title | Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria |
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