A Visual Pigment Expressed in Both Rod and Cone Photoreceptors
Rods and cones contain closely related but distinct G protein-coupled receptors, opsins, which have diverged to meet the differing requirements of night and day vision. Here, we provide evidence for an exception to that rule. Results from immunohistochemistry, spectrophotometry, and single-cell RT-P...
Gespeichert in:
| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2001-11, Vol.32 (3), p.451-461 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 461 |
|---|---|
| container_issue | 3 |
| container_start_page | 451 |
| container_title | Neuron (Cambridge, Mass.) |
| container_volume | 32 |
| creator | Ma, Jian-xing Znoiko, Sergey Othersen, Kashelle L. Ryan, James C. Das, Joydip Isayama, Tomoki Kono, Masahiro Oprian, Daniel D. Corson, D.Wesley Cornwall, M.Carter Cameron, David A. Harosi, Ferenc I. Makino, Clint L. Crouch, Rosalie K. |
| description | Rods and cones contain closely related but distinct G protein-coupled receptors, opsins, which have diverged to meet the differing requirements of night and day vision. Here, we provide evidence for an exception to that rule. Results from immunohistochemistry, spectrophotometry, and single-cell RT-PCR demonstrate that, in the tiger salamander, the green rods and blue-sensitive cones contain the same opsin. In contrast, the two cells express distinct G protein transducin α subunits: rod α transducin in green rods and cone α transducin in blue-sensitive cones. The different transducins do not appear to markedly affect photon sensitivity or response kinetics in the green rod and blue-sensitive cone. This suggests that neither the cell topology or the transducin is sufficient to differentiate the rod and the cone response. |
| doi_str_mv | 10.1016/S0896-6273(01)00482-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72286513</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0896627301004822</els_id><sourcerecordid>72286513</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-726a261d8a7e3c742a4c240d1e80a2358fc40efdca4840903762a41f30b9d77e3</originalsourceid><addsrcrecordid>eNqFkE1PGzEURS1UBOHjJ4C8qtrFlPc8HntmA0oj2iJFArXA1jL2m8ZVMg7jSVX-PQ6JyjLSk-7m3Helw9gZwhcEVBe_oG5UoYQuPwF-BpC1KMQeGyE0upDYNB_Y6D9yyI5S-gOAsmrwgB0iamiwUiN2OeaPIa3snN-F3wvqBn79b9lTSuR56PjXOMz4z-i57TyfxI743SwOsSdHyxzphO23dp7odJvH7OHb9f3kRzG9_X4zGU8LJyUOhRbKCoW-tppKp6Ww0gkJHqkGK8qqbp0Ear2zspbQQKlVRrAt4anxOneO2cfN32Ufn1eUBrMIydF8bjuKq2S0ELWqsNwJYl2qfFUGqw3o-phST61Z9mFh-xeDYNaGzZths9ZnAM2bYSNy73w7sHpakH9vbZVm4GoDUPbxN1BvkgvUOfIhaxuMj2HHxCvi_ojB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18368365</pqid></control><display><type>article</type><title>A Visual Pigment Expressed in Both Rod and Cone Photoreceptors</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Ma, Jian-xing ; Znoiko, Sergey ; Othersen, Kashelle L. ; Ryan, James C. ; Das, Joydip ; Isayama, Tomoki ; Kono, Masahiro ; Oprian, Daniel D. ; Corson, D.Wesley ; Cornwall, M.Carter ; Cameron, David A. ; Harosi, Ferenc I. ; Makino, Clint L. ; Crouch, Rosalie K.</creator><creatorcontrib>Ma, Jian-xing ; Znoiko, Sergey ; Othersen, Kashelle L. ; Ryan, James C. ; Das, Joydip ; Isayama, Tomoki ; Kono, Masahiro ; Oprian, Daniel D. ; Corson, D.Wesley ; Cornwall, M.Carter ; Cameron, David A. ; Harosi, Ferenc I. ; Makino, Clint L. ; Crouch, Rosalie K.</creatorcontrib><description>Rods and cones contain closely related but distinct G protein-coupled receptors, opsins, which have diverged to meet the differing requirements of night and day vision. Here, we provide evidence for an exception to that rule. Results from immunohistochemistry, spectrophotometry, and single-cell RT-PCR demonstrate that, in the tiger salamander, the green rods and blue-sensitive cones contain the same opsin. In contrast, the two cells express distinct G protein transducin α subunits: rod α transducin in green rods and cone α transducin in blue-sensitive cones. The different transducins do not appear to markedly affect photon sensitivity or response kinetics in the green rod and blue-sensitive cone. This suggests that neither the cell topology or the transducin is sufficient to differentiate the rod and the cone response.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/S0896-6273(01)00482-2</identifier><identifier>PMID: 11709156</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Ambystoma ; Animals ; Freshwater ; Retinal Cone Photoreceptor Cells - metabolism ; Retinal Pigments - biosynthesis ; Retinal Rod Photoreceptor Cells - metabolism ; Transducin - biosynthesis</subject><ispartof>Neuron (Cambridge, Mass.), 2001-11, Vol.32 (3), p.451-461</ispartof><rights>2001 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-726a261d8a7e3c742a4c240d1e80a2358fc40efdca4840903762a41f30b9d77e3</citedby><cites>FETCH-LOGICAL-c441t-726a261d8a7e3c742a4c240d1e80a2358fc40efdca4840903762a41f30b9d77e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0896-6273(01)00482-2$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11709156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Jian-xing</creatorcontrib><creatorcontrib>Znoiko, Sergey</creatorcontrib><creatorcontrib>Othersen, Kashelle L.</creatorcontrib><creatorcontrib>Ryan, James C.</creatorcontrib><creatorcontrib>Das, Joydip</creatorcontrib><creatorcontrib>Isayama, Tomoki</creatorcontrib><creatorcontrib>Kono, Masahiro</creatorcontrib><creatorcontrib>Oprian, Daniel D.</creatorcontrib><creatorcontrib>Corson, D.Wesley</creatorcontrib><creatorcontrib>Cornwall, M.Carter</creatorcontrib><creatorcontrib>Cameron, David A.</creatorcontrib><creatorcontrib>Harosi, Ferenc I.</creatorcontrib><creatorcontrib>Makino, Clint L.</creatorcontrib><creatorcontrib>Crouch, Rosalie K.</creatorcontrib><title>A Visual Pigment Expressed in Both Rod and Cone Photoreceptors</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>Rods and cones contain closely related but distinct G protein-coupled receptors, opsins, which have diverged to meet the differing requirements of night and day vision. Here, we provide evidence for an exception to that rule. Results from immunohistochemistry, spectrophotometry, and single-cell RT-PCR demonstrate that, in the tiger salamander, the green rods and blue-sensitive cones contain the same opsin. In contrast, the two cells express distinct G protein transducin α subunits: rod α transducin in green rods and cone α transducin in blue-sensitive cones. The different transducins do not appear to markedly affect photon sensitivity or response kinetics in the green rod and blue-sensitive cone. This suggests that neither the cell topology or the transducin is sufficient to differentiate the rod and the cone response.</description><subject>Ambystoma</subject><subject>Animals</subject><subject>Freshwater</subject><subject>Retinal Cone Photoreceptor Cells - metabolism</subject><subject>Retinal Pigments - biosynthesis</subject><subject>Retinal Rod Photoreceptor Cells - metabolism</subject><subject>Transducin - biosynthesis</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEURS1UBOHjJ4C8qtrFlPc8HntmA0oj2iJFArXA1jL2m8ZVMg7jSVX-PQ6JyjLSk-7m3Helw9gZwhcEVBe_oG5UoYQuPwF-BpC1KMQeGyE0upDYNB_Y6D9yyI5S-gOAsmrwgB0iamiwUiN2OeaPIa3snN-F3wvqBn79b9lTSuR56PjXOMz4z-i57TyfxI743SwOsSdHyxzphO23dp7odJvH7OHb9f3kRzG9_X4zGU8LJyUOhRbKCoW-tppKp6Ww0gkJHqkGK8qqbp0Ear2zspbQQKlVRrAt4anxOneO2cfN32Ufn1eUBrMIydF8bjuKq2S0ELWqsNwJYl2qfFUGqw3o-phST61Z9mFh-xeDYNaGzZths9ZnAM2bYSNy73w7sHpakH9vbZVm4GoDUPbxN1BvkgvUOfIhaxuMj2HHxCvi_ojB</recordid><startdate>20011108</startdate><enddate>20011108</enddate><creator>Ma, Jian-xing</creator><creator>Znoiko, Sergey</creator><creator>Othersen, Kashelle L.</creator><creator>Ryan, James C.</creator><creator>Das, Joydip</creator><creator>Isayama, Tomoki</creator><creator>Kono, Masahiro</creator><creator>Oprian, Daniel D.</creator><creator>Corson, D.Wesley</creator><creator>Cornwall, M.Carter</creator><creator>Cameron, David A.</creator><creator>Harosi, Ferenc I.</creator><creator>Makino, Clint L.</creator><creator>Crouch, Rosalie K.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20011108</creationdate><title>A Visual Pigment Expressed in Both Rod and Cone Photoreceptors</title><author>Ma, Jian-xing ; Znoiko, Sergey ; Othersen, Kashelle L. ; Ryan, James C. ; Das, Joydip ; Isayama, Tomoki ; Kono, Masahiro ; Oprian, Daniel D. ; Corson, D.Wesley ; Cornwall, M.Carter ; Cameron, David A. ; Harosi, Ferenc I. ; Makino, Clint L. ; Crouch, Rosalie K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-726a261d8a7e3c742a4c240d1e80a2358fc40efdca4840903762a41f30b9d77e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Ambystoma</topic><topic>Animals</topic><topic>Freshwater</topic><topic>Retinal Cone Photoreceptor Cells - metabolism</topic><topic>Retinal Pigments - biosynthesis</topic><topic>Retinal Rod Photoreceptor Cells - metabolism</topic><topic>Transducin - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Jian-xing</creatorcontrib><creatorcontrib>Znoiko, Sergey</creatorcontrib><creatorcontrib>Othersen, Kashelle L.</creatorcontrib><creatorcontrib>Ryan, James C.</creatorcontrib><creatorcontrib>Das, Joydip</creatorcontrib><creatorcontrib>Isayama, Tomoki</creatorcontrib><creatorcontrib>Kono, Masahiro</creatorcontrib><creatorcontrib>Oprian, Daniel D.</creatorcontrib><creatorcontrib>Corson, D.Wesley</creatorcontrib><creatorcontrib>Cornwall, M.Carter</creatorcontrib><creatorcontrib>Cameron, David A.</creatorcontrib><creatorcontrib>Harosi, Ferenc I.</creatorcontrib><creatorcontrib>Makino, Clint L.</creatorcontrib><creatorcontrib>Crouch, Rosalie K.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Jian-xing</au><au>Znoiko, Sergey</au><au>Othersen, Kashelle L.</au><au>Ryan, James C.</au><au>Das, Joydip</au><au>Isayama, Tomoki</au><au>Kono, Masahiro</au><au>Oprian, Daniel D.</au><au>Corson, D.Wesley</au><au>Cornwall, M.Carter</au><au>Cameron, David A.</au><au>Harosi, Ferenc I.</au><au>Makino, Clint L.</au><au>Crouch, Rosalie K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Visual Pigment Expressed in Both Rod and Cone Photoreceptors</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>2001-11-08</date><risdate>2001</risdate><volume>32</volume><issue>3</issue><spage>451</spage><epage>461</epage><pages>451-461</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>Rods and cones contain closely related but distinct G protein-coupled receptors, opsins, which have diverged to meet the differing requirements of night and day vision. Here, we provide evidence for an exception to that rule. Results from immunohistochemistry, spectrophotometry, and single-cell RT-PCR demonstrate that, in the tiger salamander, the green rods and blue-sensitive cones contain the same opsin. In contrast, the two cells express distinct G protein transducin α subunits: rod α transducin in green rods and cone α transducin in blue-sensitive cones. The different transducins do not appear to markedly affect photon sensitivity or response kinetics in the green rod and blue-sensitive cone. This suggests that neither the cell topology or the transducin is sufficient to differentiate the rod and the cone response.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11709156</pmid><doi>10.1016/S0896-6273(01)00482-2</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0896-6273 |
| ispartof | Neuron (Cambridge, Mass.), 2001-11, Vol.32 (3), p.451-461 |
| issn | 0896-6273 1097-4199 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72286513 |
| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Ambystoma Animals Freshwater Retinal Cone Photoreceptor Cells - metabolism Retinal Pigments - biosynthesis Retinal Rod Photoreceptor Cells - metabolism Transducin - biosynthesis |
| title | A Visual Pigment Expressed in Both Rod and Cone Photoreceptors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T14%3A47%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Visual%20Pigment%20Expressed%20in%20Both%20Rod%20and%20Cone%20Photoreceptors&rft.jtitle=Neuron%20(Cambridge,%20Mass.)&rft.au=Ma,%20Jian-xing&rft.date=2001-11-08&rft.volume=32&rft.issue=3&rft.spage=451&rft.epage=461&rft.pages=451-461&rft.issn=0896-6273&rft.eissn=1097-4199&rft_id=info:doi/10.1016/S0896-6273(01)00482-2&rft_dat=%3Cproquest_cross%3E72286513%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18368365&rft_id=info:pmid/11709156&rft_els_id=S0896627301004822&rfr_iscdi=true |