Analysis of in Vitro Activities of Herpes Simplex Virus Type 1 UL42 Mutant Proteins: Correlation with in Vivo Function

The DNA polymerase (pol) catalytic subunit of herpes simplex virus type 1, encoded by UL30, and its accessory factor, UL42 protein, are both essential for the replication of the virus. Because the stable interaction between UL42 and pol renders the pol fully processive for replicative DNA synthesis,...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2000-09, Vol.275 (2), p.373-390
Hauptverfasser:	Thornton, Keith E., Chaudhuri, Murari, Monahan, Steven J., Grinstead, Lynn A., Parris, Deborah S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cercopithecus aethiops Chromatography, Affinity Cricetinae DNA Replication DNA-Directed DNA Polymerase - metabolism Electrophoresis, Agar Gel Exodeoxyribonucleases Glutathione Transferase - genetics Glutathione Transferase - metabolism Herpes simplex virus Herpesvirus 1, Human - genetics Herpesvirus 1, Human - metabolism Point Mutation Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism replisome replisomes Sequence Deletion UL30 protein UL42 protein Viral Proteins - genetics Viral Proteins - metabolism Virus Replication
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