Ca2+-dependent desensitization of AMPA receptors

The effect of changes in the external concentrations (0.4-10 mM) of Ca ions on AMPA receptors (AMPARs) of different subunit composition was studied on freshly isolated rat brain neurones. Ca produces rapid and reversible voltage-independent inhibition of AMPARs. Ca -permeable and Ca -impermeable AMP...

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Veröffentlicht in:	Neuroreport 2000-09, Vol.11 (13), p.2937-2941
Hauptverfasser:	Buldakova, S L, Bolshakov, K V, Tikhonov, D B, Magazanik, L G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - pharmacology alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology Alternative Splicing Animals Animals, Newborn Antihypertensive Agents - pharmacology Benzothiadiazines - pharmacology Calcium - metabolism Calcium - pharmacology Calcium Signaling - physiology Dose-Response Relationship, Drug Glutamic Acid - pharmacology Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Kainic Acid - pharmacology Neurons - cytology Neurons - drug effects Neurons - metabolism Nootropic Agents - pharmacology Pyrrolidinones - pharmacology Rats Receptors, AMPA - drug effects Receptors, AMPA - metabolism
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