MHC diversity in Caucasians, investigated using highly heterogeneous noncoding sequence motifs at the DQB1 locus including a retroviral long terminal repeat element, and its comparison to nonhuman primate homologues

Long terminal repeats (LTRs) are common retrovirus-related sequences spread throughout the human genome. We previously reported the human-specific integration of one LTR (DQLTR3) located 15 kb upstream of HLA DQB1. To elucidate the contribution of retroviral sequences to the variability and phylogen...

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Veröffentlicht in:	Immunogenetics (New York) 2000-09, Vol.51 (11), p.898-904
Hauptverfasser:	Donner, H, Tönjes, R R, Bontrop, R E, Kurth, R, Usadel, K H, Badenhoop, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cercopithecidae - classification Cercopithecidae - genetics DNA, Complementary DQB1 gene Endogenous Retroviruses - classification Endogenous Retroviruses - genetics European Continental Ancestry Group - classification European Continental Ancestry Group - genetics Genetic Heterogeneity Genetic Variation Germany Haplotypes histocompatibility antigen HLA histocompatibility locus HLA HLA-DQ Antigens - classification HLA-DQ Antigens - genetics HLA-DQ beta-Chains Hominidae - classification Hominidae - genetics Humans Major Histocompatibility Complex Molecular Sequence Data Primates Retrovirus Sequence Homology, Nucleic Acid Terminal Repeat Sequences
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