The steroid 17alpha-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxy-pregna-3, 5-dien-20-one (SC17599) is a selective mu-opioid agonist: implications for the mu-opioid pharmacophore

The steroid SC17599 (17alpha-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxypregna -3, 5-dien-20-one) has mu-opioid actions in vivo. The ability of SC17599 to interact with opioid receptors has been studied using radioligand and [(35)S]guanosine-5'-O-(3-thio)triphosphate (GTPgammaS) binding as...

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Veröffentlicht in:	Molecular pharmacology 2000-10, Vol.58 (4), p.669-676
Hauptverfasser:	McFadyen, I J, Houshyar, H, Liu-Chen, L Y, Woods, J H, Traynor, J R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Brain - metabolism Cell Line Cell Membrane - drug effects Cell Membrane - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Guinea Pigs Humans Male Models, Molecular Pregnadienes - pharmacology Radioligand Assay Rats Rats, Sprague-Dawley Receptors, Opioid, mu - agonists Tumor Cells, Cultured
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