Occurrence of uveitis in recently diagnosed juvenile chronic arthritis: A prospective study
To examine the occurrence and characteristics of uveitis in patients with recently diagnosed juvenile chronic arthritis (JCA). A prospective observational case series. The study covered the new cases detected with JCA (426 children), all of whom were referred to an ophthalmologic consultation during...
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| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 2001-11, Vol.108 (11), p.2071-2075 |
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| description | To examine the occurrence and characteristics of uveitis in patients with recently diagnosed juvenile chronic arthritis (JCA).
A prospective observational case series.
The study covered the new cases detected with JCA (426 children), all of whom were referred to an ophthalmologic consultation during 1989 to 1996 at the Pediatric Department of the Rheumatism Foundation Hospital, Heinola, Finland.
The children with JCA were followed by ophthalmologic and pediatric examinations two to four times a year. The type and course of arthritis and presentation and characteristics of uveitis were examined prospectively.
Uveitis was detected in 104 of 426 children (24%). Two thirds of all patients and the same proportion of those with uveitis were girls. Proportionally, uveitis was found to be as common among children with oligoarthritis (27%) as among those with seronegative polyarthritis (25%). Antinuclear antibodies (ANA) were detected significantly more frequently in patients with uveitis (66%) than among those without uveitis (37%) (
P < 0.001). The uveitis was asymptomatic in 99 cases; only 5 children had episodes of acute anterior symptomatic uveitis. Uveitis was found before or within 3 months from the onset of recent arthritis in 51 of 104 children (49%) and later on in 53 of 104 children (51%). The mean age at diagnosis of uveitis was 5.9 years (range, 1.1–17.7; median, 4.9 years). The mean period from the diagnosis of JCA to the diagnosis of uveitis was 1.1 years (range, −2.4–6.5; median, 0.3 years). The mean age at diagnosis of JCA was 4.8 years (range, 0.6–15; median, 3.2 years) among those with uveitis and 7.3 years (range, 0.9–16; median, 6.7 years) among those who did not have it (
P < 0.001). Uveitis was ongoing in 63 children at the end of the follow-up period. The mean follow-up time was 4.5 years (range, 0–9.7) for all children and 5.6 years (range, 1.3–9.6) for those with uveitis. In most instances, the visual prognosis was good. In 25 of 104 patients (24%) one or more complications of uveitis were found, but in only three children did the visual acuity decrease to 20/60 or less, and none became blind. All the other patients had visual acuity ≥ 20/40.
In this patient group, uveitis in JCA frequently appeared very early after the onset of arthritis. The uveitis was significantly more common in patients with an early onset of arthritis combined with ANA positivity. The proportion of children with uveitis was as large in those with polyarthritis as in |
| doi_str_mv | 10.1016/S0161-6420(01)00773-4 |
| format | Article |
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A prospective observational case series.
The study covered the new cases detected with JCA (426 children), all of whom were referred to an ophthalmologic consultation during 1989 to 1996 at the Pediatric Department of the Rheumatism Foundation Hospital, Heinola, Finland.
The children with JCA were followed by ophthalmologic and pediatric examinations two to four times a year. The type and course of arthritis and presentation and characteristics of uveitis were examined prospectively.
Uveitis was detected in 104 of 426 children (24%). Two thirds of all patients and the same proportion of those with uveitis were girls. Proportionally, uveitis was found to be as common among children with oligoarthritis (27%) as among those with seronegative polyarthritis (25%). Antinuclear antibodies (ANA) were detected significantly more frequently in patients with uveitis (66%) than among those without uveitis (37%) (
P < 0.001). The uveitis was asymptomatic in 99 cases; only 5 children had episodes of acute anterior symptomatic uveitis. Uveitis was found before or within 3 months from the onset of recent arthritis in 51 of 104 children (49%) and later on in 53 of 104 children (51%). The mean age at diagnosis of uveitis was 5.9 years (range, 1.1–17.7; median, 4.9 years). The mean period from the diagnosis of JCA to the diagnosis of uveitis was 1.1 years (range, −2.4–6.5; median, 0.3 years). The mean age at diagnosis of JCA was 4.8 years (range, 0.6–15; median, 3.2 years) among those with uveitis and 7.3 years (range, 0.9–16; median, 6.7 years) among those who did not have it (
P < 0.001). Uveitis was ongoing in 63 children at the end of the follow-up period. The mean follow-up time was 4.5 years (range, 0–9.7) for all children and 5.6 years (range, 1.3–9.6) for those with uveitis. In most instances, the visual prognosis was good. In 25 of 104 patients (24%) one or more complications of uveitis were found, but in only three children did the visual acuity decrease to 20/60 or less, and none became blind. All the other patients had visual acuity ≥ 20/40.
In this patient group, uveitis in JCA frequently appeared very early after the onset of arthritis. The uveitis was significantly more common in patients with an early onset of arthritis combined with ANA positivity. The proportion of children with uveitis was as large in those with polyarthritis as in those with oligoarthritis, with no predilection to girls.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/S0161-6420(01)00773-4</identifier><identifier>PMID: 11713082</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Topical ; Adolescent ; Age of Onset ; Anti-Inflammatory Agents - therapeutic use ; Antibodies, Antinuclear - analysis ; Arthritis, Juvenile - complications ; Arthritis, Juvenile - diagnosis ; Arthritis, Juvenile - drug therapy ; Biological and medical sciences ; Child ; Child, Preschool ; Diseases of the osteoarticular system ; Female ; Glucocorticoids ; Humans ; Immunosuppressive Agents - therapeutic use ; Infant ; Inflammatory joint diseases ; Male ; Medical sciences ; Prospective Studies ; Uveitis - diagnosis ; Uveitis - drug therapy ; Uveitis - etiology ; Visual Acuity</subject><ispartof>Ophthalmology (Rochester, Minn.), 2001-11, Vol.108 (11), p.2071-2075</ispartof><rights>2001 American Academy of Ophthalmology, Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-6a814b1056a9b291c0c7435e5acf59eb980c690d21fb6bebc8e282614dce06cd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0161-6420(01)00773-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14134173$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11713082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kotaniemi, Kaisu</creatorcontrib><creatorcontrib>Kautiainen, Hannu</creatorcontrib><creatorcontrib>Karma, Anni</creatorcontrib><creatorcontrib>Aho, Kimmo</creatorcontrib><title>Occurrence of uveitis in recently diagnosed juvenile chronic arthritis: A prospective study</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description>To examine the occurrence and characteristics of uveitis in patients with recently diagnosed juvenile chronic arthritis (JCA).
A prospective observational case series.
The study covered the new cases detected with JCA (426 children), all of whom were referred to an ophthalmologic consultation during 1989 to 1996 at the Pediatric Department of the Rheumatism Foundation Hospital, Heinola, Finland.
The children with JCA were followed by ophthalmologic and pediatric examinations two to four times a year. The type and course of arthritis and presentation and characteristics of uveitis were examined prospectively.
Uveitis was detected in 104 of 426 children (24%). Two thirds of all patients and the same proportion of those with uveitis were girls. Proportionally, uveitis was found to be as common among children with oligoarthritis (27%) as among those with seronegative polyarthritis (25%). Antinuclear antibodies (ANA) were detected significantly more frequently in patients with uveitis (66%) than among those without uveitis (37%) (
P < 0.001). The uveitis was asymptomatic in 99 cases; only 5 children had episodes of acute anterior symptomatic uveitis. Uveitis was found before or within 3 months from the onset of recent arthritis in 51 of 104 children (49%) and later on in 53 of 104 children (51%). The mean age at diagnosis of uveitis was 5.9 years (range, 1.1–17.7; median, 4.9 years). The mean period from the diagnosis of JCA to the diagnosis of uveitis was 1.1 years (range, −2.4–6.5; median, 0.3 years). The mean age at diagnosis of JCA was 4.8 years (range, 0.6–15; median, 3.2 years) among those with uveitis and 7.3 years (range, 0.9–16; median, 6.7 years) among those who did not have it (
P < 0.001). Uveitis was ongoing in 63 children at the end of the follow-up period. The mean follow-up time was 4.5 years (range, 0–9.7) for all children and 5.6 years (range, 1.3–9.6) for those with uveitis. In most instances, the visual prognosis was good. In 25 of 104 patients (24%) one or more complications of uveitis were found, but in only three children did the visual acuity decrease to 20/60 or less, and none became blind. All the other patients had visual acuity ≥ 20/40.
In this patient group, uveitis in JCA frequently appeared very early after the onset of arthritis. The uveitis was significantly more common in patients with an early onset of arthritis combined with ANA positivity. The proportion of children with uveitis was as large in those with polyarthritis as in those with oligoarthritis, with no predilection to girls.</description><subject>Administration, Topical</subject><subject>Adolescent</subject><subject>Age of Onset</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antibodies, Antinuclear - analysis</subject><subject>Arthritis, Juvenile - complications</subject><subject>Arthritis, Juvenile - diagnosis</subject><subject>Arthritis, Juvenile - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Glucocorticoids</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Infant</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prospective Studies</subject><subject>Uveitis - diagnosis</subject><subject>Uveitis - drug therapy</subject><subject>Uveitis - etiology</subject><subject>Visual Acuity</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFO3DAQhi1EBVvKI4B8oWoPoTOJ4yRcKoRaioTEoe2pB8sZT4pRNlnsZKV9-3rZVTly8Rz8_TO_PiHOEC4RUH_5mR7MtMrhE-BngKoqMnUgFliqJlMVFodi8R85Fu9jfAIArQt1JI4REwB1vhB_HojmEHgglmMn5zX7yUfpBxmYeJj6jXTe_h3GyE4-pe_B9yzpMYyDJ2nD9Bi2gSt5LVdhjCumya9Zxml2mw_iXWf7yKf7eSJ-f__26-ZHdv9we3dzfZ9RCc2UaVujahFKbZs2b5CAKlWUXFrqyobbpgbSDbgcu1a33FLNeZ1rVI4YNLniRHzc7U0NnmeOk1n6SNz3duBxjqbK87qoGp3AcgdSqhoDd2YV_NKGjUEwW6vmxarZKjOA5sWqUSl3vj8wt0t2r6m9xgRc7AEbyfZdsAP5-MopLBRWReK-7jhOOtaeg4nkt-6dT7on40b_RpV_vK2U8A</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Kotaniemi, Kaisu</creator><creator>Kautiainen, Hannu</creator><creator>Karma, Anni</creator><creator>Aho, Kimmo</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Occurrence of uveitis in recently diagnosed juvenile chronic arthritis: A prospective study</title><author>Kotaniemi, Kaisu ; Kautiainen, Hannu ; Karma, Anni ; Aho, Kimmo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-6a814b1056a9b291c0c7435e5acf59eb980c690d21fb6bebc8e282614dce06cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Topical</topic><topic>Adolescent</topic><topic>Age of Onset</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antibodies, Antinuclear - analysis</topic><topic>Arthritis, Juvenile - complications</topic><topic>Arthritis, Juvenile - diagnosis</topic><topic>Arthritis, Juvenile - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Glucocorticoids</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Infant</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prospective Studies</topic><topic>Uveitis - diagnosis</topic><topic>Uveitis - drug therapy</topic><topic>Uveitis - etiology</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kotaniemi, Kaisu</creatorcontrib><creatorcontrib>Kautiainen, Hannu</creatorcontrib><creatorcontrib>Karma, Anni</creatorcontrib><creatorcontrib>Aho, Kimmo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology (Rochester, Minn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kotaniemi, Kaisu</au><au>Kautiainen, Hannu</au><au>Karma, Anni</au><au>Aho, Kimmo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Occurrence of uveitis in recently diagnosed juvenile chronic arthritis: A prospective study</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>108</volume><issue>11</issue><spage>2071</spage><epage>2075</epage><pages>2071-2075</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract>To examine the occurrence and characteristics of uveitis in patients with recently diagnosed juvenile chronic arthritis (JCA).
A prospective observational case series.
The study covered the new cases detected with JCA (426 children), all of whom were referred to an ophthalmologic consultation during 1989 to 1996 at the Pediatric Department of the Rheumatism Foundation Hospital, Heinola, Finland.
The children with JCA were followed by ophthalmologic and pediatric examinations two to four times a year. The type and course of arthritis and presentation and characteristics of uveitis were examined prospectively.
Uveitis was detected in 104 of 426 children (24%). Two thirds of all patients and the same proportion of those with uveitis were girls. Proportionally, uveitis was found to be as common among children with oligoarthritis (27%) as among those with seronegative polyarthritis (25%). Antinuclear antibodies (ANA) were detected significantly more frequently in patients with uveitis (66%) than among those without uveitis (37%) (
P < 0.001). The uveitis was asymptomatic in 99 cases; only 5 children had episodes of acute anterior symptomatic uveitis. Uveitis was found before or within 3 months from the onset of recent arthritis in 51 of 104 children (49%) and later on in 53 of 104 children (51%). The mean age at diagnosis of uveitis was 5.9 years (range, 1.1–17.7; median, 4.9 years). The mean period from the diagnosis of JCA to the diagnosis of uveitis was 1.1 years (range, −2.4–6.5; median, 0.3 years). The mean age at diagnosis of JCA was 4.8 years (range, 0.6–15; median, 3.2 years) among those with uveitis and 7.3 years (range, 0.9–16; median, 6.7 years) among those who did not have it (
P < 0.001). Uveitis was ongoing in 63 children at the end of the follow-up period. The mean follow-up time was 4.5 years (range, 0–9.7) for all children and 5.6 years (range, 1.3–9.6) for those with uveitis. In most instances, the visual prognosis was good. In 25 of 104 patients (24%) one or more complications of uveitis were found, but in only three children did the visual acuity decrease to 20/60 or less, and none became blind. All the other patients had visual acuity ≥ 20/40.
In this patient group, uveitis in JCA frequently appeared very early after the onset of arthritis. The uveitis was significantly more common in patients with an early onset of arthritis combined with ANA positivity. The proportion of children with uveitis was as large in those with polyarthritis as in those with oligoarthritis, with no predilection to girls.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11713082</pmid><doi>10.1016/S0161-6420(01)00773-4</doi><tpages>5</tpages></addata></record> |
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| subjects | Administration, Topical Adolescent Age of Onset Anti-Inflammatory Agents - therapeutic use Antibodies, Antinuclear - analysis Arthritis, Juvenile - complications Arthritis, Juvenile - diagnosis Arthritis, Juvenile - drug therapy Biological and medical sciences Child Child, Preschool Diseases of the osteoarticular system Female Glucocorticoids Humans Immunosuppressive Agents - therapeutic use Infant Inflammatory joint diseases Male Medical sciences Prospective Studies Uveitis - diagnosis Uveitis - drug therapy Uveitis - etiology Visual Acuity |
| title | Occurrence of uveitis in recently diagnosed juvenile chronic arthritis: A prospective study |
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