Quantification of cerebral perfusion with real-time contrast-enhanced ultrasound
No noninvasive technique is currently capable of "real-time" assessment and monitoring of cerebral blood flow (CBF). We hypothesized that cerebral perfusion could be accurately measured and monitored in "real time" with contrast-enhanced ultrasound (CEU). Cerebral perfusion was a...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2001-11, Vol.104 (21), p.2582-2587 |
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| container_title | Circulation (New York, N.Y.) |
| container_volume | 104 |
| creator | RIM, Se-Joong LEONG-POI, Howard LINDNER, Jonathan R COUTURE, Daniel ELLEGALA, Dilantha MASON, Holland DURIEUX, Marcel KASSEL, Neal F KAUL, Sanjiv |
| description | No noninvasive technique is currently capable of "real-time" assessment and monitoring of cerebral blood flow (CBF). We hypothesized that cerebral perfusion could be accurately measured and monitored in "real time" with contrast-enhanced ultrasound (CEU).
Cerebral perfusion was assessed in 9 dogs through a craniotomy with CEU at baseline and during hypercapnia and hypocapnia while normoxia was maintained. Cerebral microvascular blood volume (A), microbubble velocity (beta), and blood flow (Axbeta) were calculated from time-versus-acoustic intensity relations. Compared with baseline, hypercapnia and hypocapnia significantly increased and decreased CBF, respectively, as measured by CEU. These changes in blood flow were mediated by changes in both A and beta. A good correlation was found between Axbeta derived from CEU and CBF measured by radiolabeled microspheres (y=0.67x-0.04, r=0.91, P |
| doi_str_mv | 10.1161/hc4601.099400 |
| format | Article |
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Cerebral perfusion was assessed in 9 dogs through a craniotomy with CEU at baseline and during hypercapnia and hypocapnia while normoxia was maintained. Cerebral microvascular blood volume (A), microbubble velocity (beta), and blood flow (Axbeta) were calculated from time-versus-acoustic intensity relations. Compared with baseline, hypercapnia and hypocapnia significantly increased and decreased CBF, respectively, as measured by CEU. These changes in blood flow were mediated by changes in both A and beta. A good correlation was found between Axbeta derived from CEU and CBF measured by radiolabeled microspheres (y=0.67x-0.04, r=0.91, P<0.001).
Changes in both cerebral microvascular blood volume and red blood cell velocity can be accurately assessed with CEU. Thus, CEU has the potential for bedside measurement and monitoring of cerebral perfusion in real time in patients with craniotomies or burr holes.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/hc4601.099400</identifier><identifier>PMID: 11714654</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Biological and medical sciences ; Blood Gas Analysis ; Brain - blood supply ; Brain - physiology ; Cerebrovascular Circulation ; Contrast Media - administration & dosage ; Dogs ; Echoencephalography - methods ; Hemodynamics ; Investigative techniques, diagnostic techniques (general aspects) ; Kinetics ; Medical sciences ; Nervous system ; Ultrasonic investigative techniques</subject><ispartof>Circulation (New York, N.Y.), 2001-11, Vol.104 (21), p.2582-2587</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Nov 20, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-ac9a757f4c9eef89a59ac36142cb5c0294eb4da917e6d0c6cbab6285e4fa44493</citedby><cites>FETCH-LOGICAL-c389t-ac9a757f4c9eef89a59ac36142cb5c0294eb4da917e6d0c6cbab6285e4fa44493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3673,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14105480$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11714654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RIM, Se-Joong</creatorcontrib><creatorcontrib>LEONG-POI, Howard</creatorcontrib><creatorcontrib>LINDNER, Jonathan R</creatorcontrib><creatorcontrib>COUTURE, Daniel</creatorcontrib><creatorcontrib>ELLEGALA, Dilantha</creatorcontrib><creatorcontrib>MASON, Holland</creatorcontrib><creatorcontrib>DURIEUX, Marcel</creatorcontrib><creatorcontrib>KASSEL, Neal F</creatorcontrib><creatorcontrib>KAUL, Sanjiv</creatorcontrib><title>Quantification of cerebral perfusion with real-time contrast-enhanced ultrasound</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>No noninvasive technique is currently capable of "real-time" assessment and monitoring of cerebral blood flow (CBF). We hypothesized that cerebral perfusion could be accurately measured and monitored in "real time" with contrast-enhanced ultrasound (CEU).
Cerebral perfusion was assessed in 9 dogs through a craniotomy with CEU at baseline and during hypercapnia and hypocapnia while normoxia was maintained. Cerebral microvascular blood volume (A), microbubble velocity (beta), and blood flow (Axbeta) were calculated from time-versus-acoustic intensity relations. Compared with baseline, hypercapnia and hypocapnia significantly increased and decreased CBF, respectively, as measured by CEU. These changes in blood flow were mediated by changes in both A and beta. A good correlation was found between Axbeta derived from CEU and CBF measured by radiolabeled microspheres (y=0.67x-0.04, r=0.91, P<0.001).
Changes in both cerebral microvascular blood volume and red blood cell velocity can be accurately assessed with CEU. Thus, CEU has the potential for bedside measurement and monitoring of cerebral perfusion in real time in patients with craniotomies or burr holes.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Gas Analysis</subject><subject>Brain - blood supply</subject><subject>Brain - physiology</subject><subject>Cerebrovascular Circulation</subject><subject>Contrast Media - administration & dosage</subject><subject>Dogs</subject><subject>Echoencephalography - methods</subject><subject>Hemodynamics</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Ultrasonic investigative techniques</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1Lw0AQhhdRbK0evUoQ9Ja6n0n2KMUvKKig5zDZzNKUfNTdDeK_NyEBwdMwL8-8DA8hl4yuGUvY3c7IhLI11VpSekSWTHEZSyX0MVlSSnWcCs4X5Mz7_bAmIlWnZMFYymSi5JK8vffQhspWBkLVtVFnI4MOCwd1dEBnez-m31XYRQ6hjkPVYGS6NjjwIcZ2B63BMurrMej6tjwnJxZqjxfzXJHPx4ePzXO8fX162dxvYyMyHWIwGlKVWmk0os00KA1GJExyUyhDuZZYyBI0SzEpqUlMAUXCM4XSgpRSixW5nXoPrvvq0Ye8qbzBuoYWu97nKeeZGC4G8PofuO961w6_5ZzxVNAsG9viCTKu896hzQ-uasD95Izmo-d88pxPngf-ai7tiwbLP3oWOwA3MwDeQG3d4Knyf5xkVMmMil8bzIYN</recordid><startdate>20011120</startdate><enddate>20011120</enddate><creator>RIM, Se-Joong</creator><creator>LEONG-POI, Howard</creator><creator>LINDNER, Jonathan R</creator><creator>COUTURE, Daniel</creator><creator>ELLEGALA, Dilantha</creator><creator>MASON, Holland</creator><creator>DURIEUX, Marcel</creator><creator>KASSEL, Neal F</creator><creator>KAUL, Sanjiv</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20011120</creationdate><title>Quantification of cerebral perfusion with real-time contrast-enhanced ultrasound</title><author>RIM, Se-Joong ; LEONG-POI, Howard ; LINDNER, Jonathan R ; COUTURE, Daniel ; ELLEGALA, Dilantha ; MASON, Holland ; DURIEUX, Marcel ; KASSEL, Neal F ; KAUL, Sanjiv</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-ac9a757f4c9eef89a59ac36142cb5c0294eb4da917e6d0c6cbab6285e4fa44493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Gas Analysis</topic><topic>Brain - blood supply</topic><topic>Brain - physiology</topic><topic>Cerebrovascular Circulation</topic><topic>Contrast Media - administration & dosage</topic><topic>Dogs</topic><topic>Echoencephalography - methods</topic><topic>Hemodynamics</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Ultrasonic investigative techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RIM, Se-Joong</creatorcontrib><creatorcontrib>LEONG-POI, Howard</creatorcontrib><creatorcontrib>LINDNER, Jonathan R</creatorcontrib><creatorcontrib>COUTURE, Daniel</creatorcontrib><creatorcontrib>ELLEGALA, Dilantha</creatorcontrib><creatorcontrib>MASON, Holland</creatorcontrib><creatorcontrib>DURIEUX, Marcel</creatorcontrib><creatorcontrib>KASSEL, Neal F</creatorcontrib><creatorcontrib>KAUL, Sanjiv</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RIM, Se-Joong</au><au>LEONG-POI, Howard</au><au>LINDNER, Jonathan R</au><au>COUTURE, Daniel</au><au>ELLEGALA, Dilantha</au><au>MASON, Holland</au><au>DURIEUX, Marcel</au><au>KASSEL, Neal F</au><au>KAUL, Sanjiv</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantification of cerebral perfusion with real-time contrast-enhanced ultrasound</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2001-11-20</date><risdate>2001</risdate><volume>104</volume><issue>21</issue><spage>2582</spage><epage>2587</epage><pages>2582-2587</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>No noninvasive technique is currently capable of "real-time" assessment and monitoring of cerebral blood flow (CBF). We hypothesized that cerebral perfusion could be accurately measured and monitored in "real time" with contrast-enhanced ultrasound (CEU).
Cerebral perfusion was assessed in 9 dogs through a craniotomy with CEU at baseline and during hypercapnia and hypocapnia while normoxia was maintained. Cerebral microvascular blood volume (A), microbubble velocity (beta), and blood flow (Axbeta) were calculated from time-versus-acoustic intensity relations. Compared with baseline, hypercapnia and hypocapnia significantly increased and decreased CBF, respectively, as measured by CEU. These changes in blood flow were mediated by changes in both A and beta. A good correlation was found between Axbeta derived from CEU and CBF measured by radiolabeled microspheres (y=0.67x-0.04, r=0.91, P<0.001).
Changes in both cerebral microvascular blood volume and red blood cell velocity can be accurately assessed with CEU. Thus, CEU has the potential for bedside measurement and monitoring of cerebral perfusion in real time in patients with craniotomies or burr holes.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11714654</pmid><doi>10.1161/hc4601.099400</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biological and medical sciences Blood Gas Analysis Brain - blood supply Brain - physiology Cerebrovascular Circulation Contrast Media - administration & dosage Dogs Echoencephalography - methods Hemodynamics Investigative techniques, diagnostic techniques (general aspects) Kinetics Medical sciences Nervous system Ultrasonic investigative techniques |
| title | Quantification of cerebral perfusion with real-time contrast-enhanced ultrasound |
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