Recombinant vaccinia virus encoding human MUC1 and IL2 as immunotherapy in patients with breast cancer

Polymorphic epithelial mucin, encoded by the MUC1 gene, is present at the apical surface of glandular epithelial cells. It is over-expressed and aberrantly glycosylated in most breast tumors, resulting in an antigenically distinct molecule and a potential target for immunotherapy. This transmembrane...

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Veröffentlicht in:	Journal of immunotherapy 2000-09, Vol.23 (5), p.570-580
Hauptverfasser:	SCHOLL, Susy M, BALLOUL, Jean-Marc, FRIDMAN, Wolf, POUILLART, Pierre, ACRES, Bruce, LE GOC, Gwenaelle, BIZOUARNE, Nadine, SCHATZ, Christian, KIENY, Marie Paule, VON MENSDORFF-POUILLY, Sylvia, VINCENT-SALOMON, Anne, DENEUX, Laurent, TARTOUR, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Biological and medical sciences Breast Neoplasms - immunology Breast Neoplasms - pathology Breast Neoplasms - therapy Cancer Vaccines - administration & dosage Cytokines - secretion DNA, Complementary - metabolism DNA, Viral - metabolism Dose-Response Relationship, Drug Female Follow-Up Studies Humans Immunity, Cellular Immunotherapy Immunotherapy - methods Interleukin-2 - genetics Interleukin-2 - immunology Lymphatic Metastasis Medical sciences Middle Aged Mucin-1 - immunology Mucin-1 - metabolism Pharmacology. Drug treatments Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - therapeutic use Treatment Outcome Vaccinia virus - immunology Viral Fusion Proteins - immunology Viral Fusion Proteins - therapeutic use
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