Intra- and extracellular enzymes of collagen biosynthesis as biological and chemical targets in the control of fibrosis
The several steps in the pathway for the biosynthesis of fibrillar collagen are reviewed to illustrate potential sites for the chemotherapeutic control of fibrosis. Particular emphasis is placed upon the properties and inhibition of lysyl oxidase, the enzyme which initiates the covalent crosslinking...
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| Veröffentlicht in: | Acta tropica 2000-10, Vol.77 (1), p.147-152 |
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| container_title | Acta tropica |
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| creator | Kagan, Herbert M |
| description | The several steps in the pathway for the biosynthesis of fibrillar collagen are reviewed to illustrate potential sites for the chemotherapeutic control of fibrosis. Particular emphasis is placed upon the properties and inhibition of lysyl oxidase, the enzyme which initiates the covalent crosslinking of extracellular collagen molecules converting these to insoluble fibers, and upon the properties and inhibition of prolyl hydroxylase, the intracellular enzyme which hyroxylates proline residues within collagen. |
| doi_str_mv | 10.1016/S0001-706X(00)00128-5 |
| format | Article |
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Particular emphasis is placed upon the properties and inhibition of lysyl oxidase, the enzyme which initiates the covalent crosslinking of extracellular collagen molecules converting these to insoluble fibers, and upon the properties and inhibition of prolyl hydroxylase, the intracellular enzyme which hyroxylates proline residues within collagen.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>10996130</pmid><doi>10.1016/S0001-706X(00)00128-5</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-706X |
| ispartof | Acta tropica, 2000-10, Vol.77 (1), p.147-152 |
| issn | 0001-706X 1873-6254 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aminopropionitrile - pharmacology Animals Benzylamines - pharmacology Biological and medical sciences Cells, Cultured Collagen Collagen - biosynthesis Collagen - genetics Enzyme Inhibitors - pharmacology Esters - pharmacology Ethylamines - pharmacology Fibrosis Fibrosis - prevention & control General aspects Humans Hydroxylase Lactones - pharmacology Lysyl Medical sciences Oxidase Procollagen-Proline Dioxygenase - antagonists & inhibitors Procollagen-Proline Dioxygenase - metabolism Prolyl Protein-Lysine 6-Oxidase - antagonists & inhibitors Protein-Lysine 6-Oxidase - metabolism |
| title | Intra- and extracellular enzymes of collagen biosynthesis as biological and chemical targets in the control of fibrosis |
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