Thrombospondin-1-Mediated Metastasis Suppression by the Primary Tumor in Human Melanoma Xenografts

Some cancer patients show accelerated growth of pre-existing metastases after removal of the primary tumor. The purpose of this study was to investigate whether primary tumor-induced metastasis suppression can be mediated by thrombospondin-1 in melanoma. Human melanoma xenografts (D-12, R-18, and U-...

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Veröffentlicht in:	Journal of investigative dermatology 2001-11, Vol.117 (5), p.1042-1049
Hauptverfasser:	Rofstad, Einar K., Graff, Bjørn A.
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis inhibition Animals Antibodies, Monoclonal - pharmacology Antineoplastic agents Biological and medical sciences Chemotherapy Humans Lung - pathology Lung Neoplasms - prevention & control Lung Neoplasms - secondary Medical sciences melanoma Melanoma - blood supply Melanoma - prevention & control Melanoma - secondary metastasis suppression Mice Neoplasm Transplantation Neovascularization, Pathologic - prevention & control Pharmacology. Drug treatments Skin Neoplasms - blood supply Skin Neoplasms - pathology Thrombospondin 1 - immunology Thrombospondin 1 - physiology thrombospondin-1 Transplantation, Heterologous Tumor Cells, Cultured
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