Implication of Macrophages in Tumor Rejection Induced by CpG-oligodeoxynucleotides Without Antigen

Phosphorothioate oligodeoxynucleotides containing CpG motifs (CpG-ODNs) display broad immunostimulating activity and have potential applications in cancer immunotherapy. To investigate the antitumor activity of CpG-ODNs and to study the role of macrophages and lymphocytes in tumor rejection, CpG-ODN...

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Veröffentlicht in:	Clinical cancer research 2001-11, Vol.7 (11), p.3540-3543
Hauptverfasser:	AUF, Gregor, CARPENTIER, Antoine F, LIN CHEN, LE CLANCHE, Christelle, DELATTRE, Jean-Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - therapeutic use Animals Antigens, Neoplasm - immunology Antineoplastic agents Biological and medical sciences Cell Division - drug effects Chemotherapy Glioma - immunology Glioma - pathology Glioma - prevention & control Immunization Macrophages - immunology Male Medical sciences Mice Mice, Inbred C57BL Mice, Nude Mice, SCID Neoplasm Transplantation Neoplasms - immunology Neoplasms - pathology Neoplasms - prevention & control Oligodeoxyribonucleotides - immunology Oligodeoxyribonucleotides - therapeutic use Pharmacology. Drug treatments Rats Rats, Inbred F344 Time Factors Transplantation, Heterologous Tumor Cells, Cultured
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