Inflammation As A Key Event In The Development Of Neointima Following Vascular Balloon Injury
SUMMARY 1. The present review discusses the current evidence to implicate leucocytes as key players in the development of neointima in arteries that have been subjected to balloon angioplasty injury. 2. There is substantial clinical evidence that leucocytes are activated after angioplasty, as determ...
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| Veröffentlicht in: | Clinical and Experimental Pharmacology and Physiology 2001-11, Vol.28 (11), p.891-895 |
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| container_issue | 11 |
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| container_title | Clinical and Experimental Pharmacology and Physiology |
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| creator | Wainwright, Cl Miller, Am Wadsworth, Rm |
| description | SUMMARY
1. The present review discusses the current evidence to implicate leucocytes as key players in the development of neointima in arteries that have been subjected to balloon angioplasty injury.
2. There is substantial clinical evidence that leucocytes are activated after angioplasty, as determined by increased plasma levels of both leucocyte granulation products and soluble leucocyte and endothelial cell adhesion molecules.
3. Experimental evidence to implicate leucocytes in neointimal formation comes from studies that demonstrate leucocyte accumulation occurs within the vascular wall soon after injury and that induction of leukopenia prevents neointimal formation.
4. The evidence implicating specific adhesion molecules and cytokines in the key events leading to neointimal formation is discussed. |
| doi_str_mv | 10.1046/j.1440-1681.2001.03543.x |
| format | Article |
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1. The present review discusses the current evidence to implicate leucocytes as key players in the development of neointima in arteries that have been subjected to balloon angioplasty injury.
2. There is substantial clinical evidence that leucocytes are activated after angioplasty, as determined by increased plasma levels of both leucocyte granulation products and soluble leucocyte and endothelial cell adhesion molecules.
3. Experimental evidence to implicate leucocytes in neointimal formation comes from studies that demonstrate leucocyte accumulation occurs within the vascular wall soon after injury and that induction of leukopenia prevents neointimal formation.
4. The evidence implicating specific adhesion molecules and cytokines in the key events leading to neointimal formation is discussed.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1046/j.1440-1681.2001.03543.x</identifier><identifier>PMID: 11703391</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Angioplasty, Balloon - adverse effects ; Cell Adhesion Molecules - metabolism ; Constriction, Pathologic - etiology ; Constriction, Pathologic - metabolism ; Cytokines - metabolism ; Humans ; Inflammation - etiology ; Inflammation - metabolism ; leucocytes ; Leukocytes - physiology ; Lymphocyte Activation - physiology ; neointimal formation ; Recurrence ; restenosis ; Tunica Intima - metabolism ; vascular balloon injury</subject><ispartof>Clinical and Experimental Pharmacology and Physiology, 2001-11, Vol.28 (11), p.891-895</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4693-aade7dc3924f7cf9c749d9d24998a9634b9a5205fd25b3dcadbc728d8beb8d803</citedby><cites>FETCH-LOGICAL-c4693-aade7dc3924f7cf9c749d9d24998a9634b9a5205fd25b3dcadbc728d8beb8d803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1440-1681.2001.03543.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1440-1681.2001.03543.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,23930,23931,25140,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11703391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wainwright, Cl</creatorcontrib><creatorcontrib>Miller, Am</creatorcontrib><creatorcontrib>Wadsworth, Rm</creatorcontrib><title>Inflammation As A Key Event In The Development Of Neointima Following Vascular Balloon Injury</title><title>Clinical and Experimental Pharmacology and Physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>SUMMARY
1. The present review discusses the current evidence to implicate leucocytes as key players in the development of neointima in arteries that have been subjected to balloon angioplasty injury.
2. There is substantial clinical evidence that leucocytes are activated after angioplasty, as determined by increased plasma levels of both leucocyte granulation products and soluble leucocyte and endothelial cell adhesion molecules.
3. Experimental evidence to implicate leucocytes in neointimal formation comes from studies that demonstrate leucocyte accumulation occurs within the vascular wall soon after injury and that induction of leukopenia prevents neointimal formation.
4. The evidence implicating specific adhesion molecules and cytokines in the key events leading to neointimal formation is discussed.</description><subject>Angioplasty, Balloon - adverse effects</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Constriction, Pathologic - etiology</subject><subject>Constriction, Pathologic - metabolism</subject><subject>Cytokines - metabolism</subject><subject>Humans</subject><subject>Inflammation - etiology</subject><subject>Inflammation - metabolism</subject><subject>leucocytes</subject><subject>Leukocytes - physiology</subject><subject>Lymphocyte Activation - physiology</subject><subject>neointimal formation</subject><subject>Recurrence</subject><subject>restenosis</subject><subject>Tunica Intima - metabolism</subject><subject>vascular balloon injury</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9P2zAYhy20CTrgKyCfdkt4HTtxfODQlpZVqwoH_pyQ5djOluIkJU6g_fYktGLXXWzr9e_5WX4QwgRCAiy5XIeEMQhIkpIwAiAh0JjRcHuERl8X39AIKMQBSTmcoB_erwEghoQeoxNCOFAqyAg9L6rcqbJUbVFXeOzxGP-2Ozx7s1WLFxW-_2vxtX2zrt6Uw-g2xytbF1VblArPa-fq96L6gx-V151TDZ6oftQ3Lap11-zO0PdcOW_PD_spepjP7qe_guXtzWI6XgaaJYIGShnLjaYiYjnXudCcCSNMxIRIlUgoy4SKI4hzE8UZNVqZTPMoNWlms34Feop-7ns3Tf3aWd_KsvDaOqcqW3de8ijiIolFH0z3Qd3U3jc2l5um_0mzkwTkoFau5WBQDgbloFZ-qpXbHr04vNFlpTX_wIPLPnC1D7wXzu7-u1hOZ3fDqeeDPV_41m6_eNW8yIRTHsun1Y2cL-8mZLJaySf6AWdDluI</recordid><startdate>200111</startdate><enddate>200111</enddate><creator>Wainwright, Cl</creator><creator>Miller, Am</creator><creator>Wadsworth, Rm</creator><general>Blackwell Science Pty</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200111</creationdate><title>Inflammation As A Key Event In The Development Of Neointima Following Vascular Balloon Injury</title><author>Wainwright, Cl ; Miller, Am ; Wadsworth, Rm</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4693-aade7dc3924f7cf9c749d9d24998a9634b9a5205fd25b3dcadbc728d8beb8d803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Angioplasty, Balloon - adverse effects</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Constriction, Pathologic - etiology</topic><topic>Constriction, Pathologic - metabolism</topic><topic>Cytokines - metabolism</topic><topic>Humans</topic><topic>Inflammation - etiology</topic><topic>Inflammation - metabolism</topic><topic>leucocytes</topic><topic>Leukocytes - physiology</topic><topic>Lymphocyte Activation - physiology</topic><topic>neointimal formation</topic><topic>Recurrence</topic><topic>restenosis</topic><topic>Tunica Intima - metabolism</topic><topic>vascular balloon injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wainwright, Cl</creatorcontrib><creatorcontrib>Miller, Am</creatorcontrib><creatorcontrib>Wadsworth, Rm</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and Experimental Pharmacology and Physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wainwright, Cl</au><au>Miller, Am</au><au>Wadsworth, Rm</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammation As A Key Event In The Development Of Neointima Following Vascular Balloon Injury</atitle><jtitle>Clinical and Experimental Pharmacology and Physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>2001-11</date><risdate>2001</risdate><volume>28</volume><issue>11</issue><spage>891</spage><epage>895</epage><pages>891-895</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>SUMMARY
1. The present review discusses the current evidence to implicate leucocytes as key players in the development of neointima in arteries that have been subjected to balloon angioplasty injury.
2. There is substantial clinical evidence that leucocytes are activated after angioplasty, as determined by increased plasma levels of both leucocyte granulation products and soluble leucocyte and endothelial cell adhesion molecules.
3. Experimental evidence to implicate leucocytes in neointimal formation comes from studies that demonstrate leucocyte accumulation occurs within the vascular wall soon after injury and that induction of leukopenia prevents neointimal formation.
4. The evidence implicating specific adhesion molecules and cytokines in the key events leading to neointimal formation is discussed.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>11703391</pmid><doi>10.1046/j.1440-1681.2001.03543.x</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0305-1870 |
| ispartof | Clinical and Experimental Pharmacology and Physiology, 2001-11, Vol.28 (11), p.891-895 |
| issn | 0305-1870 1440-1681 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Angioplasty, Balloon - adverse effects Cell Adhesion Molecules - metabolism Constriction, Pathologic - etiology Constriction, Pathologic - metabolism Cytokines - metabolism Humans Inflammation - etiology Inflammation - metabolism leucocytes Leukocytes - physiology Lymphocyte Activation - physiology neointimal formation Recurrence restenosis Tunica Intima - metabolism vascular balloon injury |
| title | Inflammation As A Key Event In The Development Of Neointima Following Vascular Balloon Injury |
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