Pharmacokinetic and pharmacodynamic alterations of methyldopa in rats with aortic coarctation. A study using microdialysis

A pharmacokinetic–pharmacodynamic study of methyldopa (MD) was made in anesthetized sham operated (SO) and aortic coarctated (ACo) rats by using a vascular shunt probe for arterial microdialysis and simultaneous blood pressure recording. Anesthetized Wistar rats were used 7 days after aortic coarcta...

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Veröffentlicht in:	Pharmacological research 2001-11, Vol.44 (5), p.377-383
Hauptverfasser:	Höcht, Christian, Opezzo, Javier A.W., Gorzalczany, Susana B., Priano, Romina M., Bramuglia, Guillermo F., Taira, Carlos A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Animals Antihypertensive Agents - pharmacokinetics Antihypertensive Agents - pharmacology Aortic Coarctation - metabolism Aortic Coarctation - physiopathology aortic coarctation, pharmacokinetic, pharmacodynamic, arterial pressure, methyldopa, microdialysis, ‘shunt’ probe Blood Pressure - drug effects Corpus Striatum - drug effects Corpus Striatum - metabolism Dialysis Solutions - pharmacokinetics Hypothalamus - drug effects Hypothalamus - metabolism Methyldopa - administration & dosage Methyldopa - pharmacokinetics Methyldopa - pharmacology Microdialysis - methods Rats Rats, Wistar
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