Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88

The innate immune system evolved to recognize conserved microbial products, termed pathogen-associated molecular patterns (PAMPs), which are invariant among diverse groups of microorganisms. PAMPs are recognized by a set of germ-line encoded pattern recognition receptors (PRRs). Among the best chara...

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Veröffentlicht in:	Current biology 2000-09, Vol.10 (18), p.1139-1142
Hauptverfasser:	Schnare, Markus, Holt†, Agnieszka Czopik, Takeda, Kiyoshi, Akira, Shizuo, Medzhitov, Ruslan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Antigens, Differentiation - genetics Antigens, Differentiation - metabolism B-Lymphocytes - immunology B-Lymphocytes - metabolism CpG Islands - genetics CpG Islands - immunology Dendritic Cells - metabolism DNA - genetics DNA - metabolism Drosophila Proteins Enzyme-Linked Immunosorbent Assay Interleukin-6 - metabolism Macrophages, Peritoneal - metabolism Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Knockout MyD88 protein Myeloid Differentiation Factor 88 pathogen-associated molecular patterns Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Immunologic Signal Transduction TLR2 protein TLR4 protein Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptors
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