An investigation of the neuroprotective effect of lithium in organotypic slice cultures of rat hippocampus exposed to oxygen and glucose deprivation

Brain ischemia results in cellular degeneration and loss of function. Here we investigated the neuroprotective effect of lithium in an in vitro model of ischemia. Organotypic hippocampal slice cultures were exposed to oxygen and glucose deprivation. Cellular death was quantified by measuring uptake...

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Veröffentlicht in:	Neuroscience letters 2001-11, Vol.315 (1), p.33-36
Hauptverfasser:	Cimarosti, H., Rodnight, R., Tavares, A., Paiva, R., Valentim, L., Rocha, E., Salbego, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimanic Agents - pharmacology Biological and medical sciences Cell Death Cell Hypoxia Cerebral ischemia Culture Media Culture Techniques Dizocilpine Maleate - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fluorescence Glucose - deficiency Heat-Shock Proteins Hippocampus Hippocampus - cytology Hippocampus - drug effects HSP27 HSP27 Heat-Shock Proteins Immunoblotting Lithium Lithium Chloride - pharmacology Medical sciences Neoplasm Proteins - metabolism Neuropharmacology Neuroprotection Neuroprotective agent Neuroprotective Agents - pharmacology Organotypic culture Oxygen/glucose deprivation Pharmacology. Drug treatments Phosphorylation Rats Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
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