GDNF enhances the synaptic efficacy of dopaminergic neurons in culture

Glial cell line‐derived neurotrophic factor (GDNF) is known to promote the survival and differentiation of dopaminergic neurons of the midbrain. GDNF also causes an enhancement of dopamine release by a mechanism which is presently unclear. Using isolated dopaminergic neurons of the rat ventral tegme...

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Veröffentlicht in:	The European journal of neuroscience 2000-09, Vol.12 (9), p.3172-3180
Hauptverfasser:	Bourque, Marie-Josée, Trudeau, Louis-Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autapse Cells, Cultured Dopamine Dopamine - physiology Drosophila Proteins Excitatory Postsynaptic Potentials - physiology Fluorescent Antibody Technique gamma-Aminobutyric Acid - physiology Glial Cell Line-Derived Neurotrophic Factor Glial Cell Line-Derived Neurotrophic Factor Receptors Hypotheses Kinases Membrane Glycoproteins - analysis Membrane Potentials - drug effects Membrane Potentials - physiology Membrane Transport Proteins miniature synaptic currents Morphology Nerve Growth Factors Nerve Tissue Proteins - pharmacology Neurons - chemistry Neurons - cytology Neurons - physiology Neuropeptides Neuroprotective Agents - pharmacology Patch-Clamp Techniques Peptides Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-ret rat Rats Receptor Protein-Tyrosine Kinases - physiology Signal transduction Synapses - chemistry Synapses - drug effects Synapses - physiology synapsin Synapsins - analysis Synaptophysin - analysis Ventral Tegmental Area - cytology Vesicular Biogenic Amine Transport Proteins
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