Tyrosine phosphorylation of the catalytic subunit p110 of phosphatidylinositol-3 kinase induced by HMG-CoA reductase inhibitor inhibits its kinase activity in L6 myoblasts

Previous studies from this laboratory have shown that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (HCRI) causes apoptotic cell death of a muscle cell-derived cell line, L6 myoblasts, by involving the phosphatidylinositol-3 (PI-3) kinase pathway and tyrosine phosphorylation of several c...

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Veröffentlicht in:	FEBS letters 2001-11, Vol.508 (1), p.53-56
Hauptverfasser:	Nakagawa, Hiroto, Mutoh, Tatsuro, Kumano, Takanori, Kuriyama, Masaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Benzoquinones Catalytic Domain Cell Line Enzyme Inhibitors - pharmacology Genistein - pharmacology HMG-CoA Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Lactams, Macrocyclic Muscles - cytology Muscles - drug effects Muscles - enzymology p110 subunit Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - chemistry Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Phosphotyrosine - metabolism PI-3 kinase Precipitin Tests Protein-Tyrosine Kinases - antagonists & inhibitors Quinones - pharmacology Rats reductase inhibitor Rifabutin - analogs & derivatives Simvastatin - pharmacology tyrosine phosphorylation
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