GABA mechanisms in the pedunculopontine tegmental nucleus influence particular aspects of nicotine self-administration selectively in the rat

The pedunculopontine tegmental nucleus (PPTg) is part of the neuronal circuit activated by self-administered nicotine. The cholinergic neurons of the PPTg comprise a prominent projection to midbrain dopamine neurons. However, anatomical studies of Fos expression suggest that nicotine targets primari...

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Veröffentlicht in:	Psychopharmacologia 2001-11, Vol.158 (2), p.190-197
Hauptverfasser:	CORRIGALL, William A, COEN, Kathleen M, JIANHUA ZHANG, ADAMSON, K. Laurel
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals Baclofen Biological and medical sciences Brain Stem - drug effects Brain Stem - physiology Cocaine Cocaine - administration & dosage Dopamine Uptake Inhibitors - administration & dosage Dose-Response Relationship, Drug Drug self-administration GABA Agonists - pharmacology Glutamatergic transmission Male Medical sciences Mesencephalon Muscimol Neurons Nicotine Nicotine - administration & dosage Nicotinic Agonists - administration & dosage pedunculopontine nucleus Pedunculopontine tegmental nucleus Rats Rats, Long-Evans Reinforcement Schedule Reinforcement schedules Self Administration Tegmentum Mesencephali - drug effects Tegmentum Mesencephali - physiology Tobacco, tobacco smoking Toxicology γ-Aminobutyric acid
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