Heptaibin, a Novel Antifungal Peptaibol Antibiotic from Emericellopsis sp. BAUA8289
In the course of our antifungal screening program, a novel antifungal substance, heptaibin (1) was isolated from the culture of Emericellopsis sp. BAUA8289 together with emerimicin IV, a peptaibol antibiotic. The structure of 1 was determined by spectroscopic studies. Compound 1 was an analog of eme...
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| Veröffentlicht in: | Journal of antibiotics 2000/07/25, Vol.53(7), pp.728-732 |
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| container_title | Journal of antibiotics |
| container_volume | 53 |
| creator | ISHIYAMA, DAISUKE SATOU, TSUTOMU SENDA, HISATO FUJIMAKI, TSUKASA HONDA, REIKO KANAZAWA, SUSUMU |
| description | In the course of our antifungal screening program, a novel antifungal substance, heptaibin (1) was isolated from the culture of Emericellopsis sp. BAUA8289 together with emerimicin IV, a peptaibol antibiotic. The structure of 1 was determined by spectroscopic studies. Compound 1 was an analog of emerimicin IV, in which the isovaline residue is replaced with an alpha -amino-isobutyric acid. In this paper, we report the fermentation, isolation, structure determination and biological activities of 1. Heptaibin is produced by Emericellopsis sp. BAUA8289, a fungus isolated from the root of a rice plant growing in Akita, Japan. |
| doi_str_mv | 10.7164/antibiotics.53.728 |
| format | Article |
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BAUA8289, a fungus isolated from the root of a rice plant growing in Akita, Japan.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.53.728</identifier><identifier>PMID: 10994817</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Amino Acid Sequence ; Anti-Bacterial Agents - chemistry ; Antibiotics (antibacterial agents, antifungal agents) ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Antifungal Agents - chemistry ; Antifungal Agents - isolation & purification ; Antifungal Agents - pharmacology ; Applied microbiology ; Bacteria - drug effects ; Biological and medical sciences ; Emericellopsis ; Fermentation ; Fundamental and applied biological sciences. Psychology ; Fungi - metabolism ; Heptaibin ; Magnetic Resonance Spectroscopy ; Medical sciences ; Microbial Sensitivity Tests ; Microbiology ; Molecular Sequence Data ; Molecular Structure ; Oligopeptides - chemistry ; Oligopeptides - isolation & purification ; Oligopeptides - pharmacology ; Peptaibols ; Peptides ; Pharmacology. 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BAUA8289</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>In the course of our antifungal screening program, a novel antifungal substance, heptaibin (1) was isolated from the culture of Emericellopsis sp. BAUA8289 together with emerimicin IV, a peptaibol antibiotic. The structure of 1 was determined by spectroscopic studies. Compound 1 was an analog of emerimicin IV, in which the isovaline residue is replaced with an alpha -amino-isobutyric acid. In this paper, we report the fermentation, isolation, structure determination and biological activities of 1. Heptaibin is produced by Emericellopsis sp. 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Psychology</subject><subject>Fungi - metabolism</subject><subject>Heptaibin</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Molecular Structure</subject><subject>Oligopeptides - chemistry</subject><subject>Oligopeptides - isolation & purification</subject><subject>Oligopeptides - pharmacology</subject><subject>Peptaibols</subject><subject>Peptides</subject><subject>Pharmacology. 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BAUA8289</title><author>ISHIYAMA, DAISUKE ; SATOU, TSUTOMU ; SENDA, HISATO ; FUJIMAKI, TSUKASA ; HONDA, REIKO ; KANAZAWA, SUSUMU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-d98bc06db597605dd03c37ccee401ba208fa0711ced4f8a116de91cd8e47db093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Amino Acid Sequence</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Antibiotics (antibacterial agents, antifungal agents)</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - isolation & purification</topic><topic>Antifungal Agents - pharmacology</topic><topic>Applied microbiology</topic><topic>Bacteria - drug effects</topic><topic>Biological and medical sciences</topic><topic>Emericellopsis</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungi - metabolism</topic><topic>Heptaibin</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Molecular Structure</topic><topic>Oligopeptides - chemistry</topic><topic>Oligopeptides - isolation & purification</topic><topic>Oligopeptides - pharmacology</topic><topic>Peptaibols</topic><topic>Peptides</topic><topic>Pharmacology. 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| subjects | Amino Acid Sequence Anti-Bacterial Agents - chemistry Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Applied microbiology Bacteria - drug effects Biological and medical sciences Emericellopsis Fermentation Fundamental and applied biological sciences. Psychology Fungi - metabolism Heptaibin Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Microbiology Molecular Sequence Data Molecular Structure Oligopeptides - chemistry Oligopeptides - isolation & purification Oligopeptides - pharmacology Peptaibols Peptides Pharmacology. Drug treatments Spectrometry, Mass, Fast Atom Bombardment |
| title | Heptaibin, a Novel Antifungal Peptaibol Antibiotic from Emericellopsis sp. BAUA8289 |
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