SB-253514 and Analogues; Novel Inhibitors of Lipoprotein-Associated Phospholipase A2 Produced by Pseudomonas fluorescens DSM 11579: I. Fermentation of Producing Strain, Isolation and Biological Activity

Two new classes of inhibitors of LpPLA2 have been identified in fermentations of Pseudomonas fluorescens. The two structurally isomeric series differ in the geometry of closure of the bicyclic carbamate and comprise a range of compounds varying only in length of their lipophilic sidechain. The most...

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Veröffentlicht in:	Journal of antibiotics 2000/07/25, Vol.53(7), pp.664-669
Hauptverfasser:	THIRKETTLE, JAN, ALVAREZ, EMILIO, BOYD, HELEN, BROWN, MURRAY, DIEZ, EMILIO, HUESO, JUAN, ELSON, STEVE, FULSTON, MARK, GERSHATER, CRAIG, MORATA, MARIA LUISA, PEREZ, PALOMA, READY, SARAH, SANCHEZ-PUELLES, JOSE MARIA, SHERIDAN, ROSE, STEFANSKAC, ANNA, WARR, STEPHEN
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Alkyl-2-acetylglycerophosphocholine Esterase Animals Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Bridged Bicyclo Compounds, Heterocyclic - isolation & purification Bridged Bicyclo Compounds, Heterocyclic - metabolism Bridged Bicyclo Compounds, Heterocyclic - pharmacology Drug Evaluation, Preclinical - methods Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Fermentation Fundamental and applied biological sciences. Psychology Humans Microbiology Phospholipases A - antagonists & inhibitors Phospholipases A2 Pseudomonas fluorescens - metabolism Pyrans - isolation & purification Pyrans - metabolism Pyrans - pharmacology Rabbits
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