Factors Involved in Prolongation of the Terminal Disposition Phase of SN-38: Clinical and Experimental Studies

The active metabolite of irinotecan (CPT-11), 7-ethyl-10-hydroxycamptothecin (SN-38), is either formed through enzymatic cleavage of CPT-11 by carboxyl esterases (CEs) or through cytochrome P-450 3A-mediated oxidation to 7-ethyl-10-[4-(1-piperidino)-1-amino] carbonyloxycamptothecin (NPC) and a subse...

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Veröffentlicht in:	Clinical cancer research 2000-09, Vol.6 (9), p.3451-3458
Hauptverfasser:	KEHRER, Diederik F. S, YAMAMOTO, Wataru, VERWEIJ, Jaap, DE JONGE, Maja J. A, DE BRUIJN, Peter, SPARREBOOM, Alex
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Agents, Phytogenic - blood Antineoplastic Agents, Phytogenic - pharmacokinetics Biological and medical sciences Biotransformation Caco-2 Cells - metabolism Camptothecin - analogs & derivatives Camptothecin - blood Camptothecin - pharmacokinetics Carboxylic Ester Hydrolases - blood Chemotherapy Colorectal Neoplasms - blood Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Feces - enzymology Female Glucuronidase - metabolism Half-Life Humans Male Medical sciences Middle Aged Oxidation-Reduction Pharmacology. Drug treatments
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