Hypermagnesemia does not increase brain intracellular magnesium in newborn swine
Phosphorus-31 magnetic resonance spectroscopy was used in 2-day (n = 4) and 40-day (n = 4) miniswine to determine whether plasma hypermagnesemia alters brain intracellular magnesium concentration and if the plasma-brain intracellular magnesium relationship changes with age. At control, brain intrace...
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| Veröffentlicht in: | Pediatric neurology 2001-10, Vol.25 (4), p.304-308 |
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| creator | Gee, Jerry B Corbett, Ronald J.T Perlman, Jeffrey M Laptook, Abbot R |
| description | Phosphorus-31 magnetic resonance spectroscopy was used in 2-day (n = 4) and 40-day (n = 4) miniswine to determine whether plasma hypermagnesemia alters brain intracellular magnesium concentration and if the plasma-brain intracellular magnesium relationship changes with age. At control, brain intracellular magnesium concentration was similar in the 2-day (0.24 ± 0.04 mM) and 40-day groups (0.21 ± 0.01 mM). Intravenous infusions of magnesium sulfate (MgSO
4, 60 minute) raised plasma magnesium concentration to 4-6 mM in both groups. During and for 3 hours after MgSO
4 infusions, there were no changes in brain intracellular magnesium concentration in either group and no correlation between plasma and brain intracellular magnesium (
r = 0.11 and 0.08 for 2- and 40-day groups, respectively). Brain intracellular magnesium concentration appears to be tightly regulated. |
| doi_str_mv | 10.1016/S0887-8994(01)00317-4 |
| format | Article |
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4, 60 minute) raised plasma magnesium concentration to 4-6 mM in both groups. During and for 3 hours after MgSO
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4, 60 minute) raised plasma magnesium concentration to 4-6 mM in both groups. During and for 3 hours after MgSO
4 infusions, there were no changes in brain intracellular magnesium concentration in either group and no correlation between plasma and brain intracellular magnesium (
r = 0.11 and 0.08 for 2- and 40-day groups, respectively). Brain intracellular magnesium concentration appears to be tightly regulated.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Brain Chemistry - drug effects</subject><subject>Infusions, Intravenous</subject><subject>Magnesium - blood</subject><subject>Magnesium - pharmacokinetics</subject><subject>Magnesium Sulfate - administration & dosage</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metals (hemochromatosis...)</subject><subject>Neuroprotective Agents - administration & dosage</subject><subject>Other metabolic disorders</subject><subject>Swine</subject><issn>0887-8994</issn><issn>1873-5150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq0KVBboT2iVCxUcQmccO4lPqEJtQUICqfRs-WNSGSXO1k5A_Ptm2RUcOY1m9Lwzo4exzwjnCFh_-w1t25StUuIU8AygwqYUH9gK26YqJUrYY6tX5IAd5vwAAFJx8ZEdIDYgKqVW7O7qeU1pMH8jZRqCKfxIuYjjVIToEplMhU0mxKWdknHU93NvUrENhHlY5kWkJzumWOSnEOmY7Xemz_RpV4_Yn58_7i-vypvbX9eX329KVymcSg_CeETvRSOlsiS5QeKdAuoqx1UruaXatlZw4BK7TkmoK5LWo0XspKuO2Nft3nUa_82UJz2EvPnPRBrnrBvOm0rWagHlFnRpzDlRp9cpDCY9awS9UalfVOqNJw2oX1RqseS-7A7MdiD_ltq5W4CTHWCyM32XTHQhv3ECoZatXLiLLUeLjsdASWcXKDryIZGbtB_DO6_8B9NXkTc</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Gee, Jerry B</creator><creator>Corbett, Ronald J.T</creator><creator>Perlman, Jeffrey M</creator><creator>Laptook, Abbot R</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Hypermagnesemia does not increase brain intracellular magnesium in newborn swine</title><author>Gee, Jerry B ; Corbett, Ronald J.T ; Perlman, Jeffrey M ; Laptook, Abbot R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-d04ad11dd47559be52a1e2f90ef3c29852be6b8b420251ff95063e5bd1b11f5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Brain Chemistry - drug effects</topic><topic>Infusions, Intravenous</topic><topic>Magnesium - blood</topic><topic>Magnesium - pharmacokinetics</topic><topic>Magnesium Sulfate - administration & dosage</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metals (hemochromatosis...)</topic><topic>Neuroprotective Agents - administration & dosage</topic><topic>Other metabolic disorders</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gee, Jerry B</creatorcontrib><creatorcontrib>Corbett, Ronald J.T</creatorcontrib><creatorcontrib>Perlman, Jeffrey M</creatorcontrib><creatorcontrib>Laptook, Abbot R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gee, Jerry B</au><au>Corbett, Ronald J.T</au><au>Perlman, Jeffrey M</au><au>Laptook, Abbot R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypermagnesemia does not increase brain intracellular magnesium in newborn swine</atitle><jtitle>Pediatric neurology</jtitle><addtitle>Pediatr Neurol</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>25</volume><issue>4</issue><spage>304</spage><epage>308</epage><pages>304-308</pages><issn>0887-8994</issn><eissn>1873-5150</eissn><abstract>Phosphorus-31 magnetic resonance spectroscopy was used in 2-day (n = 4) and 40-day (n = 4) miniswine to determine whether plasma hypermagnesemia alters brain intracellular magnesium concentration and if the plasma-brain intracellular magnesium relationship changes with age. At control, brain intracellular magnesium concentration was similar in the 2-day (0.24 ± 0.04 mM) and 40-day groups (0.21 ± 0.01 mM). Intravenous infusions of magnesium sulfate (MgSO
4, 60 minute) raised plasma magnesium concentration to 4-6 mM in both groups. During and for 3 hours after MgSO
4 infusions, there were no changes in brain intracellular magnesium concentration in either group and no correlation between plasma and brain intracellular magnesium (
r = 0.11 and 0.08 for 2- and 40-day groups, respectively). Brain intracellular magnesium concentration appears to be tightly regulated.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11704399</pmid><doi>10.1016/S0887-8994(01)00317-4</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Age Factors Animals Biological and medical sciences Blood-Brain Barrier - drug effects Brain Chemistry - drug effects Infusions, Intravenous Magnesium - blood Magnesium - pharmacokinetics Magnesium Sulfate - administration & dosage Magnetic Resonance Spectroscopy Medical sciences Metabolic diseases Metals (hemochromatosis...) Neuroprotective Agents - administration & dosage Other metabolic disorders Swine |
| title | Hypermagnesemia does not increase brain intracellular magnesium in newborn swine |
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