Options for Tissue Engineering to Address Challenges of the Aging Skeleton

There will be more than 52 million Americans over the age of 65 by the year 2020 (U.S. Census Bureau). Regenerating form and function to bone defects in an elderly, osteoporotic population of this magnitude will be a daunting challenge. Tissue engineering options must be considered to answer this ch...

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Veröffentlicht in:Tissue engineering 2000-08, Vol.6 (4), p.341-350
Hauptverfasser: Hollinger, Jeffrey O., Winn, Shelley, Bonadio, Jeffrey
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container_issue 4
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container_title Tissue engineering
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creator Hollinger, Jeffrey O.
Winn, Shelley
Bonadio, Jeffrey
description There will be more than 52 million Americans over the age of 65 by the year 2020 (U.S. Census Bureau). Regenerating form and function to bone defects in an elderly, osteoporotic population of this magnitude will be a daunting challenge. Tissue engineering options must be considered to answer this challenge. Options can include gene transfer technology, stem cell therapy, and recombinant signaling molecules. An additional component will be a carrier that localizes, protects, predictably releases cues and cells, as well as establishes an environment for restoring osseous form and function. The purposes of this article are to present an overview of the bone regenerating decrement affecting osteoporotic, elderly patients and to highlight some tissue engineering options that could offset this decrement.
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subjects Aged
Aging - physiology
Animals
Biomedical Engineering
Bone Regeneration
Gene Transfer Techniques
Humans
Osteoporosis - physiopathology
Osteoporosis - therapy
Portland Bone Symposium
United States
title Options for Tissue Engineering to Address Challenges of the Aging Skeleton
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